BPG is committed to discovery and dissemination of knowledge
Cited by in CrossRef
For: Vargas-Mendoza N, Madrigal-Santillán E, Morales-González &, Esquivel-Soto J, Esquivel-Chirino C, González-Rubio MGLY, Gayosso-de-Lucio JA, Morales-González JA. Hepatoprotective effect of silymarin. World J Hepatol 2014; 6(3): 144-149 [PMID: 24672644 DOI: 10.4254/wjh.v6.i3.144]
URL: https://www.wjgnet.com/1948-5182/full/v6/i3/144.htm
Number Citing Articles
1
Roberta Di Caprio, Giuseppe Monfrecola, Franco Gasparri, Raffaella Micillo, Anna Balato, Serena Lembo. Milk thistle and olive extract: old substances with a new mission against sun-induced skin damageGiornale Italiano di Dermatologia e Venereologia 2020; 155(3) doi: 10.23736/S0392-0488.17.05726-1
2
Tzung-Hsun Tsai, Chun-Hsien Yu, Yu-Ping Chang, Yu-Ting Lin, Ching-Jang Huang, Yueh-Hsiung Kuo, Po-Jung Tsai. Protective Effect of Caffeic Acid Derivatives on tert-Butyl Hydroperoxide-Induced Oxidative Hepato-Toxicity and Mitochondrial Dysfunction in HepG2 CellsMolecules 2017; 22(5): 702 doi: 10.3390/molecules22050702
3
Zhang-He Goh, Jie Kai Tee, Han Kiat Ho. An Evaluation of the In Vitro Roles and Mechanisms of Silibinin in Reducing Pyrazinamide- and Isoniazid-Induced Hepatocellular DamageInternational Journal of Molecular Sciences 2020; 21(10): 3714 doi: 10.3390/ijms21103714
4
Roshanak Khazaei, Alireza Seidavi, Mehrdad Bouyeh. A review on the mechanisms of the effect of silymarin in milk thistle (Silybum marianum) on some laboratory animalsVeterinary Medicine and Science 2022; 8(1): 289 doi: 10.1002/vms3.641
5
Ashraf M. Abdel-Moneim, Mohammed A. Al-Kahtani, Mohamed A. El-Kersh, Mohammed A. Al-Omair, Matias A Avila. Free Radical-Scavenging, Anti-Inflammatory/Anti-Fibrotic and Hepatoprotective Actions of Taurine and Silymarin against CCl4 Induced Rat Liver DamagePLOS ONE 2015; 10(12): e0144509 doi: 10.1371/journal.pone.0144509
6
Camila S. Silva, Guilherme V. Portari, Helio Vannucchi. Molecular Aspects of Alcohol and Nutrition2016; : 119 doi: 10.1016/B978-0-12-800773-0.00010-0
7
Birhanu Geta Meharie, Gedefaw Getnet Amare, Yaschilal Muche Belayneh. <p>Evaluation of Hepatoprotective Activity of the Crude Extract and Solvent Fractions of <em>Clutia abyssinica</em> (<em>Euphorbiaceae</em>) Leaf Against CCl<sub>4</sub>-Induced Hepatotoxicity in Mice</p>Journal of Experimental Pharmacology 2020; : 137 doi: 10.2147/JEP.S248677
8
Ashkan Hassankhani Rad, Farshid Asiaee, Sevda Jafari, Ali Shayanfar, Afsaneh Lavasanifar, Ommoleila Molavi. Poly(ethylene glycol)-poly(ε-caprolactone)-based micelles for solubilization and tumor-targeted delivery of silibininBioImpacts 2019; 10(2): 87 doi: 10.34172/bi.2020.11
9
Dac Thang Hoang, Thi Thu Hien Truong, Ngo Viet Duc, Le Tuan Anh Hoang, Thi Thao Do, Le Ba Vinh, Seo Young Yang, Gao Dan, Le Tuan Anh. Hepatoprotective Effects of Extract of Helicteres hirsuta Lour. on Liver Fibrosis Induced by Carbon Tetrachloride in RatsApplied Sciences 2021; 11(18): 8758 doi: 10.3390/app11188758
10
Li Ren, Tiehua Zhang, Jie Zhang. Recent advances in dietary androgen receptor inhibitorsMedicinal Research Reviews 2024;  doi: 10.1002/med.22019
11
Priyanka Upadhyay, Mousumi Bhattacharjee, Saurav Bhattacharya, Manisha Ahir, Arghya Adhikary, Prasun Patra. Silymarin-Loaded, Lactobionic Acid-Conjugated Porous PLGA Nanoparticles Induce Apoptosis in Liver Cancer CellsACS Applied Bio Materials 2020; 3(10): 7178 doi: 10.1021/acsabm.0c00987
12
Hasandeep Singh, Tanveer Singh, Harpal Singh Buttar, Sarabjit Kaur, Saroj Arora, Istvan G. Télessy, Balbir Singh. Biomedical Translational Research2022; : 549 doi: 10.1007/978-981-16-9232-1_29
13
Ondřej Šťastník, Eva Mrkvicová, Leoš Pavlata, Andrea Roztočilová, Barbora Umlášková, Eva Anzenbacherová. Performance, Biochemical Profile and Antioxidant Activity of Hens Supplemented with Addition of Milk Thistle (Silybum marianum) Seed Cakes in DietActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis 2019; 67(4): 993 doi: 10.11118/actaun201967040993
14
Jian Tan, Jianpeng Hu, Yonghui He, Feilun Cui. RETRACTED ARTICLE: Protective role of silymarin in a mouse model of renal Ischemia–Reperfusion injuryDiagnostic Pathology 2015; 10(1) doi: 10.1186/s13000-015-0436-4
15
Prarambh S.R. Dwivedi, Vishal S. Patil, Pukar Khanal, Vishwambhar V. Bhandare, Shailendra Gurav, Darasaguppe R. Harish, B.M. Patil, Subarna Roy. System biology-based investigation of Silymarin to trace hepatoprotective effectComputers in Biology and Medicine 2022; 142: 105223 doi: 10.1016/j.compbiomed.2022.105223
16
Peng Xu, Hua Zhou, Ya-Zhuo Li, Zhong-Wen Yuan, Chang-Xiao Liu, Liang Liu, Ying Xie. Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2Frontiers in Pharmacology 2018; 9 doi: 10.3389/fphar.2018.01115
17
Priyanka Saha, Anupam Das Talukdar, Rajat Nath, Satyajit D. Sarker, Lutfun Nahar, Jagajjit Sahu, Manabendra Dutta Choudhury. Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated GenesFrontiers in Pharmacology 2019; 10 doi: 10.3389/fphar.2019.00509
18
Dianelena Eugenio-Pérez, Héctor Adolfo Montes de Oca-Solano, José Pedraza-Chaverri. Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicityPharmaceutical Biology 2016; 54(10): 2340 doi: 10.3109/13880209.2016.1150302
19
Zaenah Zuhair Alamri. Protective and therapeutic effects of apigenin on thioacetamide-induced hepatotoxicity in male rats: physiological and morphological studyEgyptian Liver Journal 2024; 14(1) doi: 10.1186/s43066-024-00318-7
20
Roberto Marceddu, Lucia Dinolfo, Alessandra Carrubba, Mauro Sarno, Giuseppe Di Miceli. Milk Thistle (Silybum Marianum L.) as a Novel Multipurpose Crop for Agriculture in Marginal Environments: A ReviewAgronomy 2022; 12(3): 729 doi: 10.3390/agronomy12030729
21
Edén M. Rodríguez-Flores, Dulce Mata-Espinosa, Jorge Barrios-Payan, Brenda Marquina-Castillo, Mauricio Castañón-Arreola, Rogelio Hernández-Pando, Selvakumar Subbian. A significant therapeutic effect of silymarin administered alone, or in combination with chemotherapy, in experimental pulmonary tuberculosis caused by drug-sensitive or drug-resistant strains: In vitro and in vivo studiesPLOS ONE 2019; 14(5): e0217457 doi: 10.1371/journal.pone.0217457
22
Maryam Mombeini, Ghasem Saki, Layasadat Khorsandi, Neda Bavarsad. Effects of Silymarin-Loaded Nanoparticles on HT-29 Human Colon Cancer CellsMedicina 2018; 54(1): 1 doi: 10.3390/medicina54010001
23
Miriam Watafua, Jane I. Ejiofor, Aminu Musa, Mubarak Hussaini Ahmad. Acacia sieberiana (Fabaceae) attenuates paracetamol and Bile Duct Ligation-Induced hepatotoxicity via modulation of biochemical and oxidative stress biomarkersFrontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.959661
24
Hemlata Bhardwaj, Neeru Vasudeva, Sunil Sharma. Possible Mechanism and Pharmacological Activities of a Flavolignan SilibininCurrent Bioactive Compounds 2023; 19(7) doi: 10.2174/1573407219666230123122441
25
Miroslav Žiaran, Jindřich Kopecký. Adverse effects of targeted cancer treatmentOnkologie 2020; 14(Suppl.C): 18 doi: 10.36290/xon.2020.051
26
Sara Verdura, Elisabet Cuyàs, Verónica Ruiz-Torres, Vicente Micol, Jorge Joven, Joaquim Bosch-Barrera, Javier A. Menendez. Lung Cancer Management with Silibinin: A Historical and Translational PerspectivePharmaceuticals 2021; 14(6): 559 doi: 10.3390/ph14060559
27
S. Yousefdoost, F. Samadi, S.M. Jafari, S.S. Ramezanpour, S. Hassani, F. Ganji. Application of nanoencapsulated silymarin to improve its antioxidant and hepatoprotective activities against carbon tetrachloride-induced oxidative stress in broiler chickensLivestock Science 2019; 228: 177 doi: 10.1016/j.livsci.2019.08.015
28
Bushra Sultana, Sadaf Yaqoob, Zohaib Zafar, Haq Nawaz Bhatti. Escalation of liver malfunctioning: A step toward Herbal AwarenessJournal of Ethnopharmacology 2018; 216: 104 doi: 10.1016/j.jep.2018.01.002
29
Sudharshan Reddy Dachani, Mohammed Kaleem, Md. Ali Mujtaba, Nilesh Mahajan, Sayyed A. Ali, Ali F Almutairy, Danish Mahmood, Md. Khalid Anwer, Mohammad Daud Ali, Sanjay Kumar. A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin CancerACS Omega 2024; 9(9): 10030 doi: 10.1021/acsomega.3c09780
30
Dinesh Mani Tripathi, Priyansha Singh, Akash Kumar Mourya, Savneet Kaur. Adaptation under Stressful Environments through Biological Adjustments and Interventions2023; : 281 doi: 10.1007/978-981-99-7652-2_18
31
Mohammed Sikander, Shabnam Malik, Anyssa Rodriguez, Murali M. Yallapu, Acharan S. Narula, Sanjaya K. Satapathy, Vijian Dhevan, Subhash C. Chauhan, Meena Jaggi. Role of Nutraceuticals in COVID-19 Mediated Liver DysfunctionMolecules 2020; 25(24): 5905 doi: 10.3390/molecules25245905
32
Nancy Vargas-Mendoza, Marcelo Ángeles-Valencia, Eduardo Osiris Madrigal-Santillán, Mauricio Morales-Martínez, Judith Margarita Tirado-Lule, Arturo Solano-Urrusquieta, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Tomás Fregoso-Aguilar, Ángel Morales-González, José A. Morales-González. Effect of Silymarin Supplementation on Physical Performance, Muscle and Myocardium Histological Changes, Bodyweight, and Food Consumption in Rats Subjected to Regular Exercise TrainingInternational Journal of Molecular Sciences 2020; 21(20): 7724 doi: 10.3390/ijms21207724
33
Marie Ange Djeungoue Petga, Arnaud Fondjo Kouam, Rosine Désirée Chougouo Kengne, Boris Rosnay Galani Tietcheu, Josué Simo Louokdom, Claude Bérenger Ngantchouko Ngalemo, Pascal Dieudonné Chuisseu Djamen, Paul Fewou Moundipa. Comparative assessment of hepatoprotective properties of Artesunate and flavonoids from Artemisia annua on acetaminophen and carbon tetrachloride-induced cytotoxicity in primary mice hepatocytesMetabolism Open 2023; 18: 100241 doi: 10.1016/j.metop.2023.100241
34
Anisatu Z. Wakhidah, Dafi Al Anshory, Wendy A. Mustaqim. Ethnobotany of the Mountain Regions of Southeast AsiaEthnobotany of Mountain Regions 2020; : 1 doi: 10.1007/978-3-030-14116-5_83-1
35
Peter Surai. Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and PerspectivesAntioxidants 2015; 4(1): 204 doi: 10.3390/antiox4010204
36
Elizabeth B. Aladejana, Adebowale E. Aladejana. Hepatoprotective activities of polyherbal formulations: A systematic reviewJournal of Medicinal Plants for Economic Development 2023; 7(1) doi: 10.4102/jomped.v7i1.206
37
Alexandros Tsoupras, Kyeesha Glenn Davi. Fungi Bioactive Metabolites2024; : 427 doi: 10.1007/978-981-99-5696-8_14
38
Mirasha Hasanthi, Sehee Jo, Han-se Kim, Kwan-Sik Yun, Yeonji Lee, Kyeong-Jun Lee. Dietary supplementation of micelle silymarin enhances the antioxidant status, innate immunity, growth performance, resistance against Vibrio parahaemolyticus infection, and gut morphology in Pacific white shrimp (Litopenaeus vannamei)Animal Feed Science and Technology 2024; 311: 115953 doi: 10.1016/j.anifeedsci.2024.115953
39
Deanna M. Minich, Benjamin I. Brown. A Review of Dietary (Phyto)Nutrients for Glutathione SupportNutrients 2019; 11(9): 2073 doi: 10.3390/nu11092073
40
Xingli Tang, Opeyemi J. Olatunji, Yifeng Zhou, Xilin Hou. Allium tuberosum : Antidiabetic and hepatoprotective activitiesFood Research International 2017; 102: 681 doi: 10.1016/j.foodres.2017.08.034
41
Ning-bo Qin, Cui-cui Jia, Jun Xu, Da-hong Li, Fan-xing Xu, Jiao Bai, Zhan-lin Li, Hui-ming Hua. New amides from seeds of Silybum marianum with potential antioxidant and antidiabetic activitiesFitoterapia 2017; 119: 83 doi: 10.1016/j.fitote.2017.04.008
42
Sandeep Subramanya, Balaji Venkataraman, Mohamed Meeran, Sameer Goyal, Chandragouda Patil, Shreesh Ojha. Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver InjuryInternational Journal of Molecular Sciences 2018; 19(12): 3776 doi: 10.3390/ijms19123776
43
Jessyca Karen Pinheiro, Lara Toledo Henriques, Severino Gonzaga Neto, Ricardo Dias Signoretti, Juliana Silva de Oliveira, Jovanna Karine Pinheiro, Renato Tonhá Alves Júnior. Uso da homeopatia no gado de leite como modulador da função hepática: uma revisãoCES Medicina Veterinaria y Zootecnia 2021; 16(1): 29 doi: 10.21615/cesmvz.16.1.2
44
Negin Mirzaei, Shahideh Jahanian Sadatmahalleh, Safoura Rouholamin, Malihe Nasiri. A randomized trial assessing the efficacy of Silymarin on endometrioma-related manifestationsScientific Reports 2022; 12(1) doi: 10.1038/s41598-022-22073-8
45
Yi-An Zhang, Xi-Zhong Shen, Ji-Min Zhu, Tao-Tao Liu. Extensive Metastatic Cholangiocarcinoma Associated With IgG4-Related Sclerosing Cholangitis Misdiagnosed as Isolated IgG4-Related Sclerosing CholangitisMedicine 2015; 94(45): e2052 doi: 10.1097/MD.0000000000002052
46
J.A. Velarde-Ruiz Velasco, M.F. Higuera-de la Tijera, G.E. Castro-Narro, F. Zamarripa-Dorsey, J.M. Abdo-Francis, I. Aiza Haddad, J.M. Aldana Ledesma, M.V. Bielsa-Fernández, E. Cerda-Reyes, L.E. Cisneros-Garza, R. Contreras-Omaña, A. Reyes-Dorantes, N.J. Fernández-Pérez, E.S. García-Jiménez, M.E. Icaza-Chávez, D. Kershenobich-Stalnikowitz, M.A. Lira-Pedrín, R. Moreno-Alcántar, J.L. Pérez-Hernández, M.V. Ramos-Gómez, M.T. Rizo-Robles, S. Solana-Sentíes, A. Torre-Delgadillo. Consenso Mexicano de hepatitis alcohólicaRevista de Gastroenterología de México 2020; 85(3): 332 doi: 10.1016/j.rgmx.2020.04.002
47
Sathish Kumar Mungamuri, Yamini Javvadi. Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers2020; : 261 doi: 10.1007/978-3-030-48405-7_12
48
Andrea Mega, Luca Marzi, Michael Kob, Andrea Piccin, Annarosa Floreani. Food and Nutrition in the Pathogenesis of Liver DamageNutrients 2021; 13(4): 1326 doi: 10.3390/nu13041326
49
Wen-Long Sun, Sha Hua, Xin-Yu Li, Liang Shen, Hao Wu, Hong-Fang Ji. Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarinNature Communications 2023; 14(1) doi: 10.1038/s41467-023-36079-x
50
Sarah M. El-Kot, Wessam Wanas, Afaf M. Hafez, Nihal A. Mahmoud, Amina M. Tolba, Abeer H. Younis, Gamal El Sayed, Huda E. Abdelwahab. Effect of silymarin on the relative gene expressions of some inflammatory cytokines in the liver of CCl4-intoxicated male ratsScientific Reports 2023; 13(1) doi: 10.1038/s41598-023-42250-7
51
Aline Maria Stolf, Cibele Campos Cardoso, Alexandra Acco. Effects of Silymarin on Diabetes Mellitus Complications: A ReviewPhytotherapy Research 2017; 31(3): 366 doi: 10.1002/ptr.5768
52
Hanaa R. Aboelwafa, Attalla F. El-kott, Eman M. Abd-Ella, Hany N. Yousef. The Possible Neuroprotective Effect of Silymarin against Aluminum Chloride-Prompted Alzheimer’s-Like Disease in RatsBrain Sciences 2020; 10(9): 628 doi: 10.3390/brainsci10090628
53
Z.M.M. Omar, A.A.-N. Ahmed, M.H. El-Bakry, M.A. Ahmed, A. Hasan. Metformin versus silymarin as hepatoprotective agents in mice fibrotic model caused by carbon tetrachlorideAnnales Pharmaceutiques Françaises 2022; 80(5): 659 doi: 10.1016/j.pharma.2022.01.005
54
Cory Szybala, Mollie Parker Szybala, Peter B. Bongiorno. Textbook of Natural Medicine2020; : 1358 doi: 10.1016/B978-0-323-43044-9.00176-X
55
M. R. Bahman, N. B. Feldman, S. N. Orekhov, N. E. Sedyakina, T. I. Gromovykh, S. V. Lutsenko. Saturation of Bacterial Cellulose with Silymarin Flavolignans in the Composition of Lipid NanoparticlesNanobiotechnology Reports 2021; 16(2): 239 doi: 10.1134/S2635167621020038
56
Rostislav Vecera, Martin Poruba, Martina Hüttl, Hana Malinska, Olena Oliyarnyk, Irena Markova, Zuzana Racova, Jan Soukop, Ludmila Kazdova. Beneficial Effect of Fenofibrate and Silymarin on Hepatic Steatosis and Gene Expression of Lipogenic and Cytochrome P450 Enzymes in Non-Obese Hereditary Hypertriglyceridemic RatsCurrent Issues in Molecular Biology 2022; 44(5): 1889 doi: 10.3390/cimb44050129
57
Gholamreza Karimi, Samed Hassanzadeh-Josan, Bahram Memar, Seyed-Alireza Esmaeili, Bamdad Riahi-Zanjani. Immunomodulatory effects of silymarin after subacute exposure to mice: A tiered approach immunotoxicity screeningJournal of Pharmacopuncture 2018; 21(2): 90 doi: 10.3831/KPI.2018.21.011
58
Venkatraman Sriramavaratharajan, David Raj Chellappan, Shanmugam Karthi, Mathialagan Ilamathi, Ramar Murugan. Multi target interactions of essential oil nanoemulsion of Cinnamomum travancoricum against diabetes mellitus via in vitro, in vivo and in silico approachesProcess Biochemistry 2022; 118: 190 doi: 10.1016/j.procbio.2022.04.031
59
Sepide Amini, Mohammad Bagherniya, Alexandra E. Butler, Gholamreza Askari, Amirhossein Sahebkar. The effect of medicinal plants on cirrhosis: A systematic review of clinical trialsPhytotherapy Research 2023; 37(7): 3083 doi: 10.1002/ptr.7816
60
Anisatu Z. Wakhidah, Dafi Al Anshory, Wendy A. Mustaqim. Ethnobotany of the Mountain Regions of Southeast AsiaEthnobotany of Mountain Regions 2021; : 439 doi: 10.1007/978-3-030-38389-3_83
61
Fahimeh Lavi Arab, Forouzan Yousefi, Mahmoud Reza Jaafari, Arezoo Rajabian, Hassan Dana, Nafiseh Tabasi, Saeed Behboodifar, Arezoo Faridzadeh, Mahmoud Mahmoudi. Evaluation of the immune-modulatory, anti-oxidant, proliferative, and anti-apoptotic effects of nano-silymarin on mesenchymal stem cells isolated from multiple sclerosis patients' adipose tissue sourcesJournal of Functional Foods 2024; 113: 105958 doi: 10.1016/j.jff.2023.105958
62
Peter Bond, William Llewellyn, Peter Van Mol. Anabolic androgenic steroid-induced hepatotoxicityMedical Hypotheses 2016; 93: 150 doi: 10.1016/j.mehy.2016.06.004
63
Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan. The interplay of arsenic, silymarin, and NF-ĸB pathway in male reproductive toxicity: A reviewEcotoxicology and Environmental Safety 2023; 252: 114614 doi: 10.1016/j.ecoenv.2023.114614
64
Kenji Okita, Toru Mizuguchi, Ota Shigenori, Masayuki Ishii, Toshihiko Nishidate, Tomomi Ueki, Makoto Meguro, Yasutoshi Kimura, Naoki Tanimizu, Norihisa Ichinohe, Toshihiko Torigoe, Takashi Kojima, Toshihiro Mitaka, Noriyuki Sato, Norimasa Sawada, Koichi Hirata. Pancreatic regeneration: basic research and gene regulationSurgery Today 2016; 46(6): 633 doi: 10.1007/s00595-015-1215-2
65
Merehan Alaa-ElDin. Mohamed, Shaimaa Rihan, Mustafa M.M. Elbakry, Said S. Moselhy. Molecular docking targeting autophagy pathway mediate abrogation of NASH by specific functional foods: update reviewNatural Product Research 2024; : 1 doi: 10.1080/14786419.2024.2316328
66
Tuba Maryam, Nosheen Fatima Rana, Sultan M. Alshahrani, Farhat Batool, Misha Fatima, Tahreem Tanweer, Salma Saleh Alrdahe, Yasmene F. Alanazi, Ifat Alsharif, Fatima S. Alaryani, Amer Sohail Kashif, Farid Menaa. Silymarin Encapsulated Liposomal Formulation: An Effective Treatment Modality against Copper Toxicity Associated Liver Dysfunction and Neurobehavioral Abnormalities in Wistar RatsMolecules 2023; 28(3): 1514 doi: 10.3390/molecules28031514
67
Guqi Wang, Peng Liang, Ping Li, Yang Hui Tan, Herbert L. Bonkovsky. The Role of Traditional Chinese Medicines (TCM) and Other Complementary and Alternative Medicines (CAM) in the Management of Chronic Hepatitis BCurrent Hepatology Reports 2019; 18(3): 316 doi: 10.1007/s11901-019-00480-2
68
Sergey V. Lutsenko, Tatiana I. Gromovykh, Ivan I. Krasnyuk, Ivan A. Vasilenko, Nataliya B. Feldman. Antihepatotoxic Activity of Liposomal SilibininBioNanoScience 2018; 8(2): 581 doi: 10.1007/s12668-018-0512-9
69
YZ Eid, RA Hassan, SA El-soud, N Eldebani. The Protective Role of Silymarin to Ameliorate the Adverse Effects of Ochratoxin-A in Laying Hens on Productive Performance, Blood Biochemistry, Hematological and Antioxidants StatusBrazilian Journal of Poultry Science 2022; 24(2) doi: 10.1590/1806-9061-2021-1515
70
M.I. Sakamoto, A.E. Murakami, A.M. Fernandes, I.C. Ospina-Rojas, K.C. Nunes, A.K. Hirata. Performance and serum biochemical profile of Japanese quail supplemented with silymarin and contaminated with aflatoxin B1Poultry Science 2018; 97(1): 159 doi: 10.3382/ps/pex277
71
Noura M. Ali, Amr A. A. Mahmoud, Mona F. Mahmoud, Hassan M. El Fayoumi. Glycyrrhizic acid and silymarin alleviate the neurotoxic effects of aluminum in rats challenged with fructose-induced insulin resistance: possible role of toll-like receptor 4 pathwayDrug and Chemical Toxicology 2019; 42(2): 210 doi: 10.1080/01480545.2018.1544984
72
Peizhen Xiao, Hong Ji, Yuantu Ye, Baotong Zhang, Yongsheng Chen, Jingjing Tian, Pin Liu, Liqiao Chen, Zhenyu Du. Dietary silymarin supplementation promotes growth performance and improves lipid metabolism and health status in grass carp (Ctenopharyngodon idellus) fed diets with elevated lipid levelsFish Physiology and Biochemistry 2017; 43(1): 245 doi: 10.1007/s10695-016-0283-6
73
Arpita Basu, Paramita Basu, Timothy J. Lyons. Biomarkers in Liver DiseaseBiomarkers in Disease: Methods, Discoveries and Applications 2017; : 957 doi: 10.1007/978-94-007-7675-3_35
74
Mizuki Ogino, Kohei Yamada, Hideyuki Sato, Satomi Onoue. Enhanced nutraceutical functions of herbal oily extract employing formulation technology: The present and futurePharmaNutrition 2022; 22: 100318 doi: 10.1016/j.phanu.2022.100318
75
Afroza Akter, Roni Roy, Mohammad Anwarul Basher. In-vivo hepatoprotective and hypoglycemic effects of methanolic extract of Schumannianthus dichotomus rhizomePhytomedicine Plus 2023; 3(3): 100459 doi: 10.1016/j.phyplu.2023.100459
76
Gwang-Mo Shin, Sushruta Koppula, Yun-Jin Chae, Hyun-Su Kim, Jae-Dong Lee, Myong-Ki Kim, MinDong Song. Anti-hepatofibrosis effect ofAllium senescensin activated hepatic stellate cells and thioacetamide-induced fibrosis rat modelPharmaceutical Biology 2018; 56(1): 632 doi: 10.1080/13880209.2018.1529801
77
Vahid Soleimani, Parisa Sadat Delghandi, Seyed Adel Moallem, Gholamreza Karimi. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated reviewPhytotherapy Research 2019; 33(6): 1627 doi: 10.1002/ptr.6361
78
Adriana Elena Bulboacă, Alina Silvia Porfire, Vasile Rus, Cristina Ariadna Nicula, Corneliu Angelo Bulboacă, Sorana D. Bolboacă. Protective Effect of Liposomal Epigallocatechin-Gallate in Experimental Gentamicin-Induced HepatotoxicityAntioxidants 2022; 11(2): 412 doi: 10.3390/antiox11020412
79
Jae Young Yu, Hanh Thuy Nguyen, Chul Soon Yong, Hyoung Geun Park, Joon Ho Jun, Jong Oh Kim. Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in ratsLaboratory Animal Research 2018; 34(2): 49 doi: 10.5625/lar.2018.34.2.49
80
Tiancong Wu, Wen Liu, Wenjie Guo, Xixu Zhu. Silymarin suppressed lung cancer growth in mice via inhibiting myeloid-derived suppressor cellsBiomedicine & Pharmacotherapy 2016; 81: 460 doi: 10.1016/j.biopha.2016.04.039
81
Farida N. Abdelrazek, Rodayna A. Shalaby, Sally A. Fahim, Reham M. Essam, Shady E. Anis, Yasmin M. Attia, Nevine S. Abd El Malak. Novel fast dissolving freeze dried sublingual baicalin tablets for enhanced hepatoprotective effect: in-vitro characterization, cell viability, and in-vivo evaluationPharmaceutical Development and Technology 2024; : 1 doi: 10.1080/10837450.2024.2341243
82
Fatemeh Rezaee-Tazangi, Negar Varaa, Layasadat Khorsandi, Mohammadreza Abbaspour. Effects of Silymarin-Loaded Polylactic-co-Glycolic Acid Nanoparticles on Osteoarthritis in RatsIranian Journal of Science and Technology, Transactions A: Science 2020; 44(3): 605 doi: 10.1007/s40995-020-00870-y
83
Maja Hitl, Neda Gavarić, Nebojša Kladar, Snežana Brkić, Isidora Samojlik, Gordana Dragović, Biljana Božin. Herbal preparations use in prevention and treatment of gastrointestinal and hepatic disorders—Data from Vojvodina, SerbiaComplementary Therapies in Medicine 2019; 43: 265 doi: 10.1016/j.ctim.2019.02.018
84
Devaraj Ezhilarasan. Phytochemicals as Lead Compounds for New Drug Discovery2020; : 195 doi: 10.1016/B978-0-12-817890-4.00012-3
85
Ravi Gundadka Shriram, Afrasim Moin, Hadil Faris Alotaibi, El-Sayed Khafagy, Ahmed Al Saqr, Amr Selim Abu Lila, Rompicherla Narayana Charyulu. Phytosomes as a Plausible Nano-Delivery System for Enhanced Oral Bioavailability and Improved Hepatoprotective Activity of SilymarinPharmaceuticals 2022; 15(7): 790 doi: 10.3390/ph15070790
86
Geeta Deswal, Kumar Guarve, Priyanka Kriplani, Ashwani K. Dhingra, Bhawna Chopra, Jaspreet Sidana. Hepatoprotective Activity of Tectona grandis Against CCl4-Induced Hepatic Damage in RatsThe Open Pharmacology Journal 2019; 9(1): 5 doi: 10.2174/1874143601909010005
87
Hassan Mohammadi, Hamed Manouchehri, Reza Changizi, Fatemeh Bootorabi, Mohammad Reza Khorramizadeh. Concurrent metformin and silibinin therapy in diabetes: assessments in zebrafish (Danio rerio) animal modelJournal of Diabetes & Metabolic Disorders 2020; 19(2): 1233 doi: 10.1007/s40200-020-00637-7
88
Jia Lin Tan, Janine Stam, Aad P. van den Berg, Patrick F. van Rheenen, Bart G. J. Dekkers, Daan J. Touw. Amanitin intoxication: effects of therapies on clinical outcomes – a review of 40 years of reported casesClinical Toxicology 2022; 60(11): 1251 doi: 10.1080/15563650.2022.2098139
89
Ahmed A. Albassam, Reginald F. Frye, John S. Markowitz. The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomesChemico-Biological Interactions 2017; 271: 24 doi: 10.1016/j.cbi.2017.04.025
90
Jinyu Wang, Luxin Zhang, Hao Cao, Xinyi Shi, Xiaorong Zhang, Zihao Gao, Katsumi Ikeda, Tingxu Yan, Ying Jia, Fanxing Xu. Silibinin improves L-cell mass and function through an estrogen receptor-mediated antioxidative mechanismPhytomedicine 2022; 99: 154022 doi: 10.1016/j.phymed.2022.154022
91
Zainul Amiruddin Zakaria, Farah Hidayah Kamisan, Teh Lay Kek, Mohd. Zaki Salleh. Hepatoprotective and antioxidant activities of Dicranopteris linearis leaf extract against paracetamol-induced liver intoxication in ratsPharmaceutical Biology 2020; 58(1): 478 doi: 10.1080/13880209.2020.1764058
92
Giuseppe Castaldo, Luigi Monaco, Laura Castaldo, Paolo Sorrentino. A 2-Week Course of Enteral Treatment with a Very Low-Calorie Protein-Based Formula for the Management of Severe ObesityInternational Journal of Endocrinology 2015; 2015: 1 doi: 10.1155/2015/723735
93
Janice Patricia Kinney, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Mayank Gangwar, Snehasis Jana, Eman Refaat Youness. Cell-Based Vital Organs Specific Biomarkers Assessment using Biofield Energy Based Novel Test FormulationJournal of Biotechnology and Biomedical Science 2019; 2(1): 31 doi: 10.14302/issn.2576-6694.jbbs-19-2944
94
Vieri Piazzini, Laura Micheli, Cristina Luceri, Mario D'Ambrosio, Lorenzo Cinci, Carla Ghelardini, Anna Rita Bilia, Lorenzo Di Cesare Mannelli, Maria Camilla Bergonzi. Nanostructured lipid carriers for oral delivery of silymarin: Improving its absorption and in vivo efficacy in type 2 diabetes and metabolic syndrome modelInternational Journal of Pharmaceutics 2019; 572: 118838 doi: 10.1016/j.ijpharm.2019.118838
95
Jog Raj, Marko Vasiljević, Panagiotis Tassis, Hunor Farkaš, Klaus Männer. Efficacy of a multicomponent mycotoxin detoxifying agent on concurrent exposure to zearalenone and T-2 mycotoxin in weaned pigsLivestock Science 2020; 242: 104295 doi: 10.1016/j.livsci.2020.104295
96
Arpita Basu, Paramita Basu, Timothy J. Lyons. Biomarkers in Liver DiseaseBiomarkers in Disease: Methods, Discoveries and Applications 2016; : 1 doi: 10.1007/978-94-007-7742-2_35-1
97
Dominique L. Braun, Andri Rauch, Manel Aouri, Nina Durisch, Nadia Eberhard, Alexia Anagnostopoulos, Bruno Ledergerber, Beat Müllhaupt, Karin J. Metzner, Laurent Decosterd, Jürg Böni, Rainer Weber, Jan Fehr, Sarah L George. A Lead-In with Silibinin Prior to Triple-Therapy Translates into Favorable Treatment Outcomes in Difficult-To-Treat HIV/Hepatitis C Coinfected PatientsPLOS ONE 2015; 10(7): e0133028 doi: 10.1371/journal.pone.0133028
98
Wafaa R. Mohamed, Amr S. Kotb, Ola M. Abd El‐Raouf, Ebtehal Mohammad Fikry. Apigenin alleviated acetaminophen‐induced hepatotoxicity in low protein‐fed rats: Targeting oxidative stress, STAT3, and apoptosis signalsJournal of Biochemical and Molecular Toxicology 2020; 34(5) doi: 10.1002/jbt.22472
99
Maha B. Salem, Dina Mostafa Mohammed, Olfat A. Hammam, Mohamed Elzallat. Mitigation of intrahepatic cholestasis induced by 17α-ethinylestradiol via nanoformulation of Silybum marianum L.BMC Complementary Medicine and Therapies 2024; 24(1) doi: 10.1186/s12906-024-04351-2
100
Masoud Ghiasian, Hamid Nafisi, Akram Ranjbar, Younes Mohammadi, Sara Ataei. Antioxidative effects of silymarin on the reduction of liver complications of fingolimod in patients with relapsing–remitting multiple sclerosis: A clinical trial studyJournal of Biochemical and Molecular Toxicology 2021; 35(8) doi: 10.1002/jbt.22800
101
LAKKARAJU CHANDANA, DARNA BHIKSHAPATHI. FREE RADICAL SCAVENGING ACTIVITY OF PLEUROTUS OSTREATUS AGAINST CCL4-INDUCED HEPATIC DAMAGE IN WISTER RATSInternational Journal of Pharmacy and Pharmaceutical Sciences 2023; : 17 doi: 10.22159/ijpps.2023v15i12.49478
102
Ghazal Sadat Askarpour Moezian, Seyed Alireza Javadinia, Soodabeh Shahid Sales, Azar Fanipakdel, Sepideh Elyasi, Gholamreza Karimi. Oral silymarin formulation efficacy in management of AC-T protocol induced hepatotoxicity in breast cancer patients: A randomized, triple blind, placebo-controlled clinical trialJournal of Oncology Pharmacy Practice 2022; 28(4): 827 doi: 10.1177/10781552211006182
103
Colin E. Evans. Hypoxia-Inducible Factor Signaling in Inflammatory Lung Injury and RepairCells 2022; 11(2): 183 doi: 10.3390/cells11020183
104
Yi-Hao Chen, Ching-Long Chen, Da-Wen Lu, Chang-Min Liang, Ming-Cheng Tai, Jiann-Torng Chen, Eve-Isabelle PECHEUR. Silibinin Inhibits Platelet-Derived Growth Factor-Driven Cell Proliferation via Downregulation of N-Glycosylation in Human Tenon's Fibroblasts in a Proteasome-Dependent MannerPLOS ONE 2016; 11(12): e0168765 doi: 10.1371/journal.pone.0168765
105
Behrouz Khaleghipour, Heshmatollah Khosravinia, Majid Toghiyani, Arash Azarfar. Efficacy of silymarin-nanohydrogle complex in attenuation of aflatoxins toxicity in Japanese quailsItalian Journal of Animal Science 2020; 19(1): 351 doi: 10.1080/1828051X.2020.1743782
106
Khara Lucius. Nutritional and Botanical Approaches for Nonalcoholic Fatty Liver DiseaseAlternative and Complementary Therapies 2020; 26(6): 246 doi: 10.1089/act.2020.29303.klu
107
Milad Iranshahy, Mehrdad Iranshahi, Seyed Reza Abtahi, Gholamreza Karimi. The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: A reviewFood and Chemical Toxicology 2018; 120: 261 doi: 10.1016/j.fct.2018.07.024
108
Mohamed El-Far, Neven Salah, Alaa Essam, Amira O Abd El-Azim, Ibrahim M El-Sherbiny. Silymarin nanoformulation as potential anticancer agent in experimental Ehrlich ascites carcinoma-bearing animalsNanomedicine 2018; 13(15): 1865 doi: 10.2217/nnm-2017-0394
109
Archana Singh, Dheeraj K. Singh, Ravindra N. Kharwar, James F. White, Surendra K. Gond. Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and ChallengesMicroorganisms 2021; 9(1): 197 doi: 10.3390/microorganisms9010197
110
Sreevarsha Gali, Swati Sharma, Amit Kundu, Eunah Lee, Joo Hee Han, Joo Kyung Shin, Ji Soo Choi, So Young Kyung, Jae-Sung Kim, Hyung Sik Kim. Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley ratsToxicology Mechanisms and Methods 2023; 33(6): 437 doi: 10.1080/15376516.2023.2171824
111
Jaemin Lee, Jinwoo Yang, Jiyoung Jeon, Heon Sang Jeong, Junsoo Lee, Jeehye Sung. Hepatoprotective effect of esculetin on ethanol-induced liver injury in human HepG2 cells and C57BL/6J miceJournal of Functional Foods 2018; 40: 536 doi: 10.1016/j.jff.2017.11.024
112
Muhammad Zeeshan Bhatti, Hammad Ismail, Waqas Khan Kayani. Secondary Metabolites - Trends and Reviews2022;  doi: 10.5772/intechopen.103698
113
Kamal Niaz, Fazlullah Khan. Recent Advances in Natural Products Analysis2020; : 39 doi: 10.1016/B978-0-12-816455-6.00003-2
114
Tita Hariyanti, Ria Margiana, Moaed Emran Al-Gazally, Indrajit Patra, Ghaidaa Raheem Lateef Al-Awsi, Noora Hameed, Dilrabo Kayumova, Mohammad Javed Ansari, Larry Miguel Torres-Criollo, Yasser Fakri Mustafa, Razzagh Abedi-Firouzjah, Bagher Farhood. The Protective Effects of Silymarin on the Reproductive Toxicity: A Comprehensive ReviewCurrent Medicinal Chemistry 2023; 30(39): 4421 doi: 10.2174/0929867330666230130115332
115
Niloufar Keyhanmehr, Hossein Motedayyen, Nahid Eskandari. The Effects of Silymarin and Cyclosporine A on the Proliferation and Cytokine Production of Regulatory T CellsImmunological Investigations 2019; 48(5): 533 doi: 10.1080/08820139.2019.1571506
116
Prabhat Kumar Upadhyay, Sonia Singh, Bhupesh Chander Semwal, Vishal Kumar Vishwakarma. Assessment Methods for Various Hepatotoxicities and their Experimental Models: A ReviewThe Natural Products Journal 2023; 13(8) doi: 10.2174/2210315513666230301101049
117
Ahmed Hashem, Yogesh Shastri, Malfi Al Otaibi, Elwin Buchel, Hussam Saleh, Reyaz Ahmad, Hamouda Ahmed, Fateh Al Idris, Saleh Ahmed, Mohamed Guda, Anton Gillessen. Expert Opinion on the Management of Non-Alcoholic Fatty Liver Disease (NAFLD) in the Middle East with a Focus on the Use of SilymarinGastroenterology Insights 2021; 12(2): 155 doi: 10.3390/gastroent12020014
118
Olajumoke Olufunlayo Nwaechefu, Tomilola Debby Olaolu, Ifeoluwa Racheal Akinwunmi, Omotunde Oluwaseyi Ojezele, Olufunso Olabode Olorunsogo. Cajanus cajan ameliorated CCl4-induced oxidative stress in Wistar rats via the combined mechanisms of anti-inflammation and mitochondrial-membrane transition pore inhibitionJournal of Ethnopharmacology 2022; 289: 114920 doi: 10.1016/j.jep.2021.114920
119
Gloria Alexandra Latacela, Pushpamala Ramaiah, Indrajit Patra, Abduladheem Turki Jalil, Reena Gupta, Fakhriddin Akhmadovich Madaminov, Shafik Shaker Shafik, Moaed Emran Al-Gazally, Mohammad Javed Ansari, Mahmoud Kandeel, Yasser Fakri Mustafa, Bagher Farhood. The Radioprotective Potentials of Silymarin/Silibinin Against Radiotherapy- Induced Toxicities: A Systematic Review of Clinical and Experimental StudiesCurrent Medicinal Chemistry 2023; 30(33): 3775 doi: 10.2174/0929867330666221124155339
120
Ricardo Aparecido Baptista Nucci, Victor Abou Nehmi-Filho, Marta Ferreira Bastos, Jéssica Alves de Freitas, José Pinhata Otoch, Ana Flávia Marçal Pessoa, Wilson Jacob-Filho. Modulation of Small-Intestine Morphology in Mice by a Novel Supplement Containing Silybum marianum, Yeast β-Glucan, Prebiotics, and MineralsJournal of Health and Allied Sciences NU 2023;  doi: 10.1055/s-0043-1773807
121
Majid Eslami, Abdolmajid Ghasemian, Zahra Najafiolya, S. Ameneh Mirforughi, Farshad Nojoomi. Silymarin and curcumin effects on virulence and carbapenemase genes among multidrug-resistant Escherichia coli clinical isolatesReviews in Medical Microbiology 2018; 29(4): 177 doi: 10.1097/MRM.0000000000000143
122
Hager H. Shaaban, Ibrahim Alzaim, Ahmed El-Mallah, Rania G. Aly, Ahmed F. El-Yazbi, Ahmed Wahid. Metformin, pioglitazone, dapagliflozin and their combinations ameliorate manifestations associated with NAFLD in rats via anti-inflammatory, anti-fibrotic, anti-oxidant and anti-apoptotic mechanismsLife Sciences 2022; 308: 120956 doi: 10.1016/j.lfs.2022.120956
123
Heba Eltahir, Michael Fawzy, Elhussein Mohamed, Mahmoud Alrehany, Ahmed Shehata, Mekky Abouzied. Antioxidant, anti‑inflammatory and anti‑fibrotic effects of Boswellia serrate gum resin in CCl4‑induced hepatotoxicityExperimental and Therapeutic Medicine 2019;  doi: 10.3892/etm.2019.8353
124
A. Jabbari, B. Alani, A. Arjmand, T. Mazoochi, N. Kheiripour, A. Ardjmand. Silymarin pretreatment protects against ethanol-induced memory impairment: Biochemical and histopathological evidenceJournal of Chemical Neuroanatomy 2023; 132: 102310 doi: 10.1016/j.jchemneu.2023.102310
125
Arabinda Ghosh, Pranjal Sarmah, Harun Patel, Nobendu Mukerjee, Rajbardhan Mishra, Saad Alkahtani, Rajender S. Varma, Debabrat Baishya, Ghulam Md Ashraf. Nonlinear molecular dynamics of quercetin in Gynocardia odorata and Diospyros malabarica fruits: Its mechanistic role in hepatoprotectionPLOS ONE 2022; 17(3): e0263917 doi: 10.1371/journal.pone.0263917
126
Ali Kemal Onalan, Salih Tuncal, Sibel Kilicoglu, Salih Celepli, Esra Durak, Bulent Kilicoglu, Erdinc Devrim, Aziz Mutlu Barlas, Kemal Kismet. Effect of sılymarın on oxıdatıve stress and lıver hıstopathology ın experımental obstructıve jaundıce modelActa Cirurgica Brasileira 2016; 31(12): 801 doi: 10.1590/s0102-865020160120000004
127
Nahla N. Younis, Mohamed A. Shaheen, Mona F. Mahmoud. Silymarin preconditioning protected insulin resistant rats from liver ischemia-reperfusion injury: role of endogenous H2SJournal of Surgical Research 2016; 204(2): 398 doi: 10.1016/j.jss.2016.04.069
128
Yehudit Shabat, Yaron Ilan. A synergistic effect of Cremophor and beta glucosylceramide to exert liver and sugar protectionJournal of Food Science and Technology 2017; 54(5): 1184 doi: 10.1007/s13197-017-2520-0
129
Verawan Uchaipichat. In vitro inhibitory effects of major bioactive constituents of Andrographis paniculata, Curcuma longa and Silybum marianum on human liver microsomal morphine glucuronidation: A prediction of potential herb-drug interactions arising from andrographolide, curcumin and silybin inhibition in humansDrug Metabolism and Pharmacokinetics 2018; 33(1): 67 doi: 10.1016/j.dmpk.2017.10.005
130
Priyamvada Gupta, Ashish Verma, Nilesh Rai, Anurag Kumar Singh, Santosh Kumar Singh, Brijesh Kumar, Rajiv Kumar, Vibhav Gautam. Mass Spectrometry-Based Technology and Workflows for Studying the Chemistry of Fungal Endophyte Derived Bioactive CompoundsACS Chemical Biology 2021; 16(11): 2068 doi: 10.1021/acschembio.1c00581
131
Ragaa A. Hamouda, Ebtehail S. Aljohani. Assessment of Silver Nanoparticles Derived from Brown Algae Sargassum vulgare: Insight into Antioxidants, Anticancer, Antibacterial and Hepatoprotective EffectMarine Drugs 2024; 22(4): 154 doi: 10.3390/md22040154
132
Arnadi Ramachandrayya Shivashankara, Sunitha Venkatesh, Harshith P. Bhat, Princy Louis Palatty, Manjeshwar Shrinath Baliga. Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults2015; : 163 doi: 10.1016/B978-0-12-418680-4.00017-8
133
Jae Sue Choi, Yu Ran Han, Jeong Su Byeon, Se-Young Choung, Hee Sook Sohn, Hyun Ah Jung. Protective effect of fucosterol isolated from the edible brown algae, Ecklonia stolonifera and Eisenia bicyclis, on tert-butyl hydroperoxide- and tacrine-induced HepG2 cell injuryJournal of Pharmacy and Pharmacology 2015; 67(8): 1170 doi: 10.1111/jphp.12404
134
Dileep G Nair, Ralf Weiskirchen, Salma K Al-Musharafi. The use of marine-derived bioactive compounds as potential hepatoprotective agentsActa Pharmacologica Sinica 2015; 36(2): 158 doi: 10.1038/aps.2014.114
135
Abdelaaty A. Shahat, Riaz Ullah, Ali S. Alqahtani, Mansour S. Alsaid, Husseiny A. Husseiny, Osaid T. R. Al Meanazel. Hepatoprotective Effect ofEriobotrya japonicaLeaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in RatsEvidence-Based Complementary and Alternative Medicine 2018; 2018: 1 doi: 10.1155/2018/3782768
136
Herbert Ryan Marini, Bianca Arianna Facchini, Raffaele di Francia, José Freni, Domenico Puzzolo, Liliana Montella, Gaetano Facchini, Alessandro Ottaiano, Massimiliano Berretta, Letteria Minutoli. Glutathione: Lights and Shadows in Cancer PatientsBiomedicines 2023; 11(8): 2226 doi: 10.3390/biomedicines11082226
137
J. Anupama Sekar, Shiny Velayudhan, M. Senthilkumar, P.R. Anil Kumar. Silymarin enriched gelatin methacrylamide bioink imparts hepatoprotectivity to 3D bioprinted liver construct against carbon tetrachloride induced toxicityEuropean Journal of Pharmaceutics and Biopharmaceutics 2024; 198: 114272 doi: 10.1016/j.ejpb.2024.114272
138
Riham O. Bakr, Esraa A. Shahat, Ahmed E. Elissawy, Ahmed M. Fayez, Omayma A. Eldahshan. Evaluation of the hepatoprotective activity of Pulicaria incisa subspecies candolleana and in silico screening of its isolated phenolicsJournal of Ethnopharmacology 2021; 271: 113767 doi: 10.1016/j.jep.2020.113767
139
Jucélia Barbosa da Silva, Renata de Freitas Mendes, Vívian Tomasco, Nícolas de Castro Campos Pinto, Luiz Gustavo de Oliveira, Matheus Nehrer Rodrigues, Danielle Maria de Oliveira Aragão, Jair Adriano Kopke de Aguiar, Maria Silvana Alves, Maria Christina Nogueira Marques Castañon, Antônia Ribeiro, Elita Scio. New aspects on the hepatoprotective potential associated with the antioxidant, hypocholesterolemic and anti-inflammatory activities of Vernonia condensata BakerJournal of Ethnopharmacology 2017; 198: 399 doi: 10.1016/j.jep.2017.01.039
140
Heidar Heidari Khoei, Sajad Fakhri, Siavash Parvardeh, Zahra Shams Mofarahe, Hojjat Ghasemnejad-Berenji, Hamid Nazarian, Zahra Baninameh. Testicular toxicity and reproductive performance of streptozotocin-induced diabetic male rats: the ameliorating role of silymarin as an antioxidantToxin Reviews 2019; 38(3): 223 doi: 10.1080/15569543.2018.1444641
141
Gellan Alaa Mohamed Kamel, Eman Harahsheh, Shaimaa Hussein. Mechanisms underlying the hepatoprotective effect of silymarin on fluoxetine-induced liver injury in rats: the implication of peroxisome proliferator–activated receptor-gamma (PPAR-γ)Comparative Clinical Pathology 2022; 31(4): 689 doi: 10.1007/s00580-022-03369-7
142
Mihaela Zaulet, Steliana Elvira Maria Kevorkian, Sorina Dinescu, Coralia Cotoraci, Maria Suciu, Hildegard Herman, Laura Buburuzan, Liliana Badulescu, Aurel Ardelean, Anca Hermenean. Protective effects of silymarin against bisphenol A-induced hepatotoxicity in mouse liverExperimental and Therapeutic Medicine 2017; 13(3): 821 doi: 10.3892/etm.2017.4066
143
Oluwole S. Owojuyigbe, Christopher Larbie, Caleb K. Firempong, Gustav Komlaga, Benjamin O. Emikpe, Chiagoziem A. Otuechere. Extracts of Hura crepitans L. stem bark attenuate liver injury and inflammation induced by CCl4 in ratsComparative Clinical Pathology 2020; 29(6): 1199 doi: 10.1007/s00580-020-03172-2
144
Aida Doostkam, Mohammad Fathalipour, Mohammad Hossein Anbardar, Azar Purkhosrow, Hossein Mirkhani, Ravindran Caspa Gokulan. Therapeutic Effects of Milk Thistle (Silybum marianum L.) and Artichoke (Cynara scolymus L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic RatsCanadian Journal of Gastroenterology and Hepatology 2022; 2022: 1 doi: 10.1155/2022/2868904
145
Sreekutty P.V, Shrinidhi R, Shubha P. U, Chaithra S. Hebbar. AN AYURVEDIC OUTLOOK ON HEPATO CELLULAR CARCINOMAInternational Ayurvedic Medical Journal 2023; 11(11): 2783 doi: 10.46607/iamj1911112023
146
Wusa Makena, Yomi Samson Aribiyun, Aisha Aminu, Barka Ishaku, Ayuba Yohana, Ekwere Eke Inemesit. Flavonoids fractions of Adansonia digitata L. fruits protects adult Wistar rats from mercury chloride-induced hepatorenal toxicity: histopathological and biochemical studiesEgyptian Journal of Basic and Applied Sciences 2022; 9(1): 205 doi: 10.1080/2314808X.2022.2059140
147
Panwen Liu, Wenhui Chen, Yu Kang, Chenkang Wang, Xiaoling Wang, Weiwei Liu, Toshihiko Hayashi, Zhiyue Qiu, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima. Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease modelArchives of Biochemistry and Biophysics 2023; 744: 109691 doi: 10.1016/j.abb.2023.109691
148
Jagan Mohan Kaipa, Vytaute Starkuviene, Holger Erfle, Roland Eils, Evgeny Gladilin. Transcriptome profiling reveals Silibinin dose-dependent response network in non-small lung cancer cellsPeerJ 2020; 8: e10373 doi: 10.7717/peerj.10373
149
Zdenka Veprikova, Milena Zachariasova, Zbynek Dzuman, Alena Zachariasova, Marie Fenclova, Petra Slavikova, Marta Vaclavikova, Katerina Mastovska, Daniel Hengst, Jana Hajslova. Mycotoxins in Plant-Based Dietary Supplements: Hidden Health Risk for ConsumersJournal of Agricultural and Food Chemistry 2015; 63(29): 6633 doi: 10.1021/acs.jafc.5b02105
150
Anika Mann, Thomas Pelz, Knut Rennert, Alexander Mosig, Michael Decker, Amelie Lupp. Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substanceHuman Cell 2017; 30(4): 267 doi: 10.1007/s13577-017-0175-9
151
Amera Abd El Latif, Doaa H. Assar, Ebtihal M. Elkaw, Hanafy A. Hamza, Dalal Hussien M. Alkhalifah, Wael N. Hozzein, Ragaa A. Hamouda. Protective role of Chlorella vulgaris with Thiamine against Paracetamol induced toxic effects on haematological, biochemical, oxidative stress parameters and histopathological changes in Wistar ratsScientific Reports 2021; 11(1) doi: 10.1038/s41598-021-83316-8
152
J.A. Velarde-Ruiz Velasco, M.F. Higuera-de la Tijera, G.E. Castro-Narro, F. Zamarripa-Dorsey, J.M. Abdo-Francis, I. Aiza Haddad, J.M. Aldana Ledesma, M.V. Bielsa-Fernández, E. Cerda-Reyes, L.E. Cisneros-Garza, R. Contreras-Omaña, A. Reyes-Dorantes, N.J. Fernández-Pérez, E.S. García-Jiménez, M.E. Icaza-Chávez, D. Kershenobich-Stalnikowitz, M.A. Lira-Pedrín, R. Moreno-Alcántar, J.L. Pérez-Hernández, M.V. Ramos-Gómez, M.T. Rizo-Robles, S. Solana-Sentíes, A. Torre-Delgadillo. The Mexican consensus on alcoholic hepatitisRevista de Gastroenterología de México (English Edition) 2020; 85(3): 332 doi: 10.1016/j.rgmxen.2020.04.004
153
Claire E Manhard, Brandon Lucke-Wold. Commentary: Discussing the antidepressant potential of silymarinWorld Journal of Pharmacology 2023; 12(3): 18-24 doi: 10.5497/wjp.v12.i3.18
154
Ahmad Ghorbani, Sara Hooshmand. Protective Effects of <b><i>Morus nigra</i></b> and Its Phytochemicals against Hepatotoxicity: A Review of Preclinical StudiesPharmacology 2021; 106(5-6): 233 doi: 10.1159/000515032
155
Douglas Vieira Thomaz, Pierre Alexandre dos Santos. Redox Behavior and Radical Scavenging Capacity of Hepatoprotective Nutraceutical PreparationsCurrent Nutraceuticals 2021; 2(4): 312 doi: 10.2174/2665978602666210615110653
156
Mohammad Arman, Kazi Ashfak Ahmed Chowdhury, Md. Sazzadul Bari, Mohammad Forhad Khan, Maryam Md. Ataul Huq, Md. Areeful Haque, Raffaele Capasso. Hepatoprotective potential of selected medicinally important herbs: evidence from ethnomedicinal, toxicological and pharmacological evaluationsPhytochemistry Reviews 2022; 21(6): 1863 doi: 10.1007/s11101-022-09812-5
157
Caio Mateus Silva, Gustavo Duarte Ferrari, Luciane Carla Alberici, Osmar Malaspina, Karen C. M. Moraes. Cellular and molecular effects of silymarin on the transdifferentiation processes of LX-2 cells and its connection with lipid metabolismMolecular and Cellular Biochemistry 2020; 468(1-2): 129 doi: 10.1007/s11010-020-03717-7
158
Liliani Carolini Thiesen, Luisa Mota da Silva, José Roberto Santin, Tania Mari Bellé Bresolin, Sérgio Faloni de Andrade, Clarissa de Medeiros Amorim, Lidia Merlin, Rilton Alves de Freitas, Rivaldo Niero, Daisy Janice Aguilar Netz. Hepatoprotective effect of Maytenus robusta Reiss extract on CCl4-induced hepatotoxicity in mice and HepG2 cellsRegulatory Toxicology and Pharmacology 2017; 86: 93 doi: 10.1016/j.yrtph.2017.02.023
159
Nancy Vargas-Mendoza, Marcelo Angeles-Valencia, Ángel Morales-González, Mauricio Morales-Martínez, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Tomás Fregoso-Aguilar, Luis Delgado-Olivares, Eduardo Osiris Madrigal-Santillán, José A. Morales-González. Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent ModelJournal of Functional Morphology and Kinesiology 2021; 6(3): 72 doi: 10.3390/jfmk6030072
160
Behrouz Khaleghipour, Heshmatollah Khosravinia, Majid Toghiyani, Arash Azarfar. Effects of silymarin on productive performance, liver function and serum biochemical profile in broiler Japanese quail challenged with dietary aflatoxinsItalian Journal of Animal Science 2019; 18(1): 564 doi: 10.1080/1828051X.2018.1548310
161
Muhammad Umar Khayam Sahibzada, Abdul Sadiq, Muhammad Zahoor, Sumera Naz, Muhammad Shahid, Najam Afaq Qureshi. Enhancement of bioavailability and hepatoprotection by silibinin through conversion to nanoparticles prepared by liquid antisolvent methodArabian Journal of Chemistry 2020; 13(2): 3682 doi: 10.1016/j.arabjc.2020.01.002
162
Václav Tvrdý, Marcel Hrubša, Eduard Jirkovský, David Biedermann, Michal Kutý, Kateřina Valentová, Vladimír Křen, Přemysl Mladěnka. Silymarin Dehydroflavonolignans Chelate Zinc and Partially Inhibit Alcohol DehydrogenaseNutrients 2021; 13(12): 4238 doi: 10.3390/nu13124238
163
Tomas Koltai, Larry Fliegel. Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and QuestionsJournal of Evidence-Based Integrative Medicine 2022; 27: 2515690X2110688 doi: 10.1177/2515690X211068826
164
V. Rosato, L. Abenavoli, A. Federico, M. Masarone, M. Persico. Pharmacotherapy of alcoholic liver disease in clinical practiceInternational Journal of Clinical Practice 2016; 70(2): 119 doi: 10.1111/ijcp.12764
165
Nahum Méndez-Sánchez, Miguel Dibildox-Martinez, Jahir Sosa-Noguera, Ramón Sánchez-Medal, Francisco J. Flores-Murrieta. Superior silybin bioavailability of silybin–phosphatidylcholine complex in oily-medium soft-gel capsules versus conventional silymarin tablets in healthy volunteers*BMC Pharmacology and Toxicology 2019; 20(1) doi: 10.1186/s40360-018-0280-8
166
Jéssica Amanda Andrade Garcia-Manieri, Vanesa Gesser Correa, Emanueli Backes, Anacharis Babeto de Sá-Nakanishi, Lívia Bracht, Jurandir Fernando Comar, Rúbia Carvalho Gomes Corrêa, Rosane Marina Peralta, Adelar Bracht. A Critical Appraisal of the Most Recent Investigations on the Hepatoprotective Action of Brazilian PlantsPlants 2022; 11(24): 3481 doi: 10.3390/plants11243481
167
Ariadne Esmene Afaganis, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Mayank Gangwar, Snehasis Jana, Jun Wan. Impact of Biofield Energy Treatment Based Test Formulation on Vital Organ Health Specific Biomarkers Using Cell Line StudyJournal of Tissue Repair and Regeneration 2019; 1(2): 22 doi: 10.14302/issn.2640-6403.jtrr-19-2946
168
A. N Nwagbo, P. A Onyeyili, J. N Abenga, H.C Nwankwo. Effect of silybon 140 on pentobarbitone anaesthesia in dogs exposed to acetaminophenJournal of Veterinary Medicine and Animal Health 2021; 13(4): 172 doi: 10.5897/JVMAH2019.0770
169
Donghyuck Bae, Jihye Kim, Sun-young Lee, Eun-jin Choi, Myung-A Jung, Chang sik Jeong, Ju-ryun Na, Jae-jin Kim, Sunoh Kim. Hepatoprotective effects of aqueous extracts from leaves of Dendropanax morbifera leveille against alcohol-induced hepatotoxicity in rats and in vitro anti-oxidant effectsFood Science and Biotechnology 2015; 24(4): 1495 doi: 10.1007/s10068-015-0193-x
170
Qianying Chen, Hongzhu Chen, Wenjie Wang, Jiali Liu, Wenyue Liu, Ping Ni, Guowei Sang, Guangji Wang, Fang Zhou, Jingwei Zhang. Glycyrrhetic acid, but not glycyrrhizic acid, strengthened entecavir activity by promoting its subcellular distribution in the liver via efflux inhibitionEuropean Journal of Pharmaceutical Sciences 2017; 106: 313 doi: 10.1016/j.ejps.2017.06.015
171
Fernanda Caetano Camini, Daniela Caldeira Costa. Silymarin: not just another antioxidantJournal of Basic and Clinical Physiology and Pharmacology 2020; 31(4) doi: 10.1515/jbcpp-2019-0206
172
Lubov V. Krepkova, Aleksandra N. Babenko, Olga L. Saybel’, Irina A. Lupanova, Olga S. Kuzina, Kathleen M. Job, Catherine M. Sherwin, Elena Y. Enioutina. Valuable Hepatoprotective Plants - How Can We Optimize Waste Free Uses of Such Highly Versatile Resources?Frontiers in Pharmacology 2021; 12 doi: 10.3389/fphar.2021.738504
173
Antonio Speciale, Claudia Muscarà, Maria Sofia Molonia, Francesco Cimino, Antonella Saija, Salvatore Vincenzo Giofrè. Silibinin as potential tool against SARS‐Cov‐2: In silico spike receptor‐binding domain and main protease molecular docking analysis, and in vitro endothelial protective effectsPhytotherapy Research 2021; 35(8): 4616 doi: 10.1002/ptr.7107
174
Eduardo Madrigal-Santill&aacute;n, Mirandeli Bautista, Juan A Gayosso-De-Lucio, Yadira Reyes-Rosales, Araceli Posadas-Mondrag&oacute;n, &Aacute;ngel Morales-Gonz&aacute;lez, Marvin A Soriano-Urs&uacute;a, Jazm&iacute;n Garc&iacute;a-Machorro, Eduardo Madrigal-Bujaidar, Isela &Aacute;lvarez-Gonz&aacute;lez, Jos&eacute; A Morales-Gonz&aacute;lez. Hepatoprotective effect of <italic>Geranium schiedeanum</italic> against ethanol toxicity during liver regenerationWorld Journal of Gastroenterology 2015; 21(25): 7718-7729 doi: 10.3748/wjg.v21.i25.7718
175
Meltem Macit, Gulengul Duman, Alev Cumbul, Engin Sumer, Caglar Macit. Formulation development of Silybum marianum seed extracts and silymarin nanoparticles, and evaluation of hepatoprotective effectJournal of Drug Delivery Science and Technology 2023; 83: 104378 doi: 10.1016/j.jddst.2023.104378
176
Claus Hellerbrand, Jörn M. Schattenberg, Philipp Peterburs, Anja Lechner, Reto Brignoli. The potential of silymarin for the treatment of hepatic disordersClinical Phytoscience 2017; 2(1) doi: 10.1186/s40816-016-0019-2
177
Karla MacDonald-Ramos, Layla Michán, Alejandra Martínez-Ibarra, Marco Cerbón. Silymarin is an ally against insulin resistance: A reviewAnnals of Hepatology 2021; 23: 100255 doi: 10.1016/j.aohep.2020.08.072
178
Maria Ponticelli, Ludovica Lela, Mariapia Moles, Claudia Mangieri, Donatella Bisaccia, Immacolata Faraone, Roberto Falabella, Luigi Milella. The healing bitterness of Gentiana lutea L., phytochemistry and biological activities: A systematic reviewPhytochemistry 2023; 206: 113518 doi: 10.1016/j.phytochem.2022.113518
179
A. Baradaran, F. Samadi, S.S. Ramezanpour, S. Yousefdoust. Hepatoprotective effects of silymarin on CCl4-induced hepatic damage in broiler chickens modelToxicology Reports 2019; 6: 788 doi: 10.1016/j.toxrep.2019.07.011
180
Funda Terzi, Mustafa Kemal Ciftci. Protective effect of silymarin on tacrolimus-induced kidney and liver toxicityBMC Complementary Medicine and Therapies 2022; 22(1) doi: 10.1186/s12906-022-03803-x
181
Ondrej Stastnik, Leos Pavlata, Eva Mrkvicova. The Milk Thistle Seed Cakes and Hempseed Cakes are Potential Feed for PoultryAnimals 2020; 10(8): 1384 doi: 10.3390/ani10081384
182
Farouk K. El-Baz, Abeer Salama, Rania A. A. Salama. Therapeutic Effect of Dunaliella salina Microalgae on Thioacetamide- (TAA-) Induced Hepatic Liver Fibrosis in Rats: Role of TGF-β and MMP9BioMed Research International 2019; 2019: 1 doi: 10.1155/2019/7028314
183
Tai-Long Pan, Pei-Wen Wang, Chi-Feng Hung, Ibrahim A. Aljuffali, You-Shan Dai, Jia-You Fang. The impact of retinol loading and surface charge on the hepatic delivery of lipid nanoparticlesColloids and Surfaces B: Biointerfaces 2016; 141: 584 doi: 10.1016/j.colsurfb.2016.02.029
184
Masykur ., Nurdin ., Lukman Hakim, Rosnizar ., Widya Sari, Munira Ulfa, Novi Yana Sari, Ria Ceriana. Effect of Ethanol Extract of Soursop (Annona muricata L.) Stem Bark on Rat Liver FunctionPakistan Journal of Biological Sciences 2023; 26(10): 516 doi: 10.3923/pjbs.2023.516.528
185
You‐Suk Lee, Il Je Cho, Joo Wan Kim, Min‐Ki Lee, Sae Kwang Ku, Jae‐Suk Choi, Hae‐Jeung Lee. Hepatoprotective effects of blue honeysuckle on CCl4‐induced acute liver damaged miceFood Science & Nutrition 2019; 7(1): 322 doi: 10.1002/fsn3.893
186
Václav Tvrdý, Jana Pourová, Eduard Jirkovský, Vladimír Křen, Kateřina Valentová, Přemysl Mladěnka. Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarinMedicinal Research Reviews 2021; 41(4): 2195 doi: 10.1002/med.21791
187
Gökçe Şeker Karatoprak. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases2021; : 209 doi: 10.1016/B978-0-12-816488-4.00008-5
188
Guadalupe Martínez, Susana Nelly Diéguez, Edgardo Rodríguez, Julieta María Decundo, Agustina Romanelli, María Belén Fernández Paggi, Denisa Soledad Pérez Gaudio, Fabián Andrés Amanto, Alejandro Luis Soraci. Effect of Cynara scolymus and Silybum marianum extracts on bile production in pigsJournal of Applied Animal Research 2018; 46(1): 1059 doi: 10.1080/09712119.2018.1456441
189
Sawsan Mohammed Kareem, Suhad Saad Mahmood, Nada KhazalKadhim Hindi. Effects of Curcumin and Silymarin on the Shigella dysenteriae and Campylobacter jejuni In vitroJournal of Gastrointestinal Cancer 2020; 51(3): 824 doi: 10.1007/s12029-019-00301-1
190
Bogdan Okiljević, Nikola Martić, Srđan Govedarica, Bojana Andrejić Višnjić, Milana Bosanac, Jovan Baljak, Branimir Pavlić, Isidora Milanović, Aleksandar Rašković. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative StressPharmaceutics 2024; 16(4): 520 doi: 10.3390/pharmaceutics16040520
191
N. Younis, Mohamed A. Shaheen, Marwa H Abdallah. Silymarin-loaded Eudragit ® RS100 nanoparticles improved the ability of silymarin to resolve hepatic fibrosis in bile duct ligated ratsBiomedicine & Pharmacotherapy 2016; 81: 93 doi: 10.1016/j.biopha.2016.03.042
192
Darya Pon`kina, Sergey Kuranov, Mikhail Khvostov, Nataliya Zhukova, Yulia Meshkova, Mariya Marenina, Olga Luzina, Tatyana Tolstikova, Nariman Salakhutdinov. Hepatoprotective Effect of a New FFAR1 Agonist—N-Alkylated IsobornylamineMolecules 2023; 28(1): 396 doi: 10.3390/molecules28010396
193
Manish Adhikari, Bhawana Adhikari, Bhagirath Ghimire, Sanjula Baboota, Eun Ha Choi. Cold Atmospheric Plasma and Silymarin Nanoemulsion Activate Autophagy in Human Melanoma CellsInternational Journal of Molecular Sciences 2020; 21(6): 1939 doi: 10.3390/ijms21061939
194
Birgit M. Dietz, Atieh Hajirahimkhan, Tareisha L. Dunlap, Judy L. Bolton, Eric Barker. Botanicals and Their Bioactive Phytochemicals for Women’s HealthPharmacological Reviews 2016; 68(4): 1026 doi: 10.1124/pr.115.010843
195
Rasha Mamdouh Salama, Sara Gamal Tayel. Silymarin attenuates escitalopram (cipralex) induced pancreatic injury in adult male albino rats: a biochemical, histological, and immunohistochemical approachAnatomy & Cell Biology 2023; 56(1): 122 doi: 10.5115/acb.22.204
196
Erqun Song, Xiaomin Xia, Chuanyang Su, Wenjing Dong, Yaping Xian, Wei Wang, Yang Song. Hepatotoxicity and genotoxicity of patulin in mice, and its modulation by green tea polyphenols administrationFood and Chemical Toxicology 2014; 71: 122 doi: 10.1016/j.fct.2014.06.009
197
Yahya Z. Eid, Yassin Omara, Asmaa Ragab, Ahmed Ismail, Mohsen Zommara, Mahmoud A. O. Dawood. Mitigation of Imidacloprid Toxicity in Poultry Chicken by Selenium Nanoparticles: Growth Performance, Lipid Peroxidation, and Blood TraitsBiological Trace Element Research 2023; 201(11): 5379 doi: 10.1007/s12011-023-03592-5
198
Mahendra Kumar Trivedi, Snehasis Jana, Osmar Centurion. In vitro Assessment of the Biofield Treated Test Item on Cardiac Function Using Rat Cardiomyocytes Cell Line (H9c2) via Multiparametric AnalysisJournal Of Hypertension And Cardiology 2019; 2(4): 1 doi: 10.14302/issn.2329-9487.jhc-19-2582
199
Jéssica Amâncio Martins, Melina Castilho de Souza Balbueno, Cidéli de Paula Coelho. Action of Carduus marianus 6cH on Hepatopathy and Gallstone in Ambystoma mexicanum (Axolotl): Case ReportHomeopathy 2024;  doi: 10.1055/s-0043-1778686
200
Adejoke Yetunde Onaolapo, Hameed Sulaiman, Anthony Tope Olofinnade, Olakunle James Onaolapo. Antidepressant-like potential of silymarin and silymarin-sertraline combination in mice: Highlighting effects on behaviour, oxidative stress, and neuroinflammationWorld Journal of Pharmacology 2022; 11(3): 27-47 doi: 10.5497/wjp.v11.i3.27
201
Myoung-Jin Kim, Dong-Uk Kim, Ji-Won Choi, Dong-Gu Kim, Ho-Joon Song, Gi-Sang Bae, Sung-Joo Park. Silymarin Attenuates the Severity of Cerulein-Induced Acute PancreatitisPancreas 2020; 49(1): 89 doi: 10.1097/MPA.0000000000001453
202
Pankaj Garg, Sanjay Awasthi, David Horne, Ravi Salgia, Sharad S. Singhal. The innate effects of plant secondary metabolites in preclusion of gynecologic cancers: Inflammatory response and therapeutic actionBiochimica et Biophysica Acta (BBA) - Reviews on Cancer 2023; 1878(4): 188929 doi: 10.1016/j.bbcan.2023.188929
203
K. O. Kalko, S. M. Drogovoz, O. Ya. Mishchenko, L. B. Ivantsyk, K. O. Dehtiarova, М. М. Lukashuk, I. М. Lukashuk, O. V. Gerush, A. O. Palamar, O. N. Korovenkova, S. I. Shevchenko. CHRONOPHARMACOLOGICAL FEATURES OF SILIMARIN’S HEPATOPROTECTOCAL ACTIVITY UNDER PARACETAMOL HEPATITIS IN RATSLikarska sprava 2020; (1-2): 63 doi: 10.31640/JVD.1-2.2020(9)
204
Dalia H. El-Kashef, Randa A. Zaghloul. Ameliorative effect of montelukast against carbon tetrachloride-induced hepatotoxicity: Targeting NLRP3 inflammasome pathwayLife Sciences 2022; 304: 120707 doi: 10.1016/j.lfs.2022.120707
205
Samaneh Hossainzadeh, Najmeh Ranji, Alireza Naderi Sohi, Farhood Najafi. Silibinin encapsulation in polymersome: A promising anticancer nanoparticle for inducing apoptosis and decreasing the expression level of miR‐125b/miR‐182 in human breast cancer cellsJournal of Cellular Physiology 2019; 234(12): 22285 doi: 10.1002/jcp.28795
206
C Jia, Z Zhang, J Wang, Z Nie. Silymarin protects the rats against paraquat-induced acute kidney injury via Nrf2Human & Experimental Toxicology 2022; 41: 096032712210743 doi: 10.1177/09603271221074334
207
Geir Bjørklund, Maryam Dadar, Salvatore Chirumbolo, Roman Lysiuk. Flavonoids as detoxifying and pro-survival agents: What's new?Food and Chemical Toxicology 2017; 110: 240 doi: 10.1016/j.fct.2017.10.039
208
Marianne Marianne, Mariadi Mariadi, Sony Eka Nugraha, Rosnani Nasution, Pran Nando Syuhada, Sylvia Pandiangan. Characteristics and Hepatoprotective Activity of the Curcuma heyneana Rhizome Extract toward Wistar Rats Induced by EthanolJundishapur Journal of Natural Pharmaceutical Products 2021; 16(4) doi: 10.5812/jjnpp.112653
209
Ümit Erdoğan, Evren Homan Gökçe, Muhammed Tilahun Muhammed, Ebru Önem, Ayten Asena Erten, Buse Süleymanoğlu. Milk thistle extracts could enhance the UV-protection efficiency and stability of mineral filters in sunscreen formulationsJournal of Photochemistry and Photobiology A: Chemistry 2024; 450: 115460 doi: 10.1016/j.jphotochem.2024.115460
210
Ling Qiu, Ruibing Feng, Qiu-shuang Wu, Jian-bo Wan, Qing-wen Zhang. Total saponins from Panax japonicus attenuate acute alcoholic liver oxidative stress and hepatosteatosis by p62-related Nrf2 pathway and AMPK-ACC/PPARα axis in vivo and in vitroJournal of Ethnopharmacology 2023; 317: 116785 doi: 10.1016/j.jep.2023.116785
211
C. Delgado-Montemayor, P. Cordero-Pérez, R. Salazar-Aranda, N. Waksman-Minsky. Models of hepatoprotective activity assessmentMedicina Universitaria 2015; 17(69): 222 doi: 10.1016/j.rmu.2015.10.002
212
Chen-Yi Liao, Ching-Chang Lee, Chi-chang Tsai, Chao-Wen Hsueh, Chih-Chiang Wang, I-Hung Chen, Ming-Kai Tsai, Mei-Yu Liu, An-Tie Hsieh, Kuan-Jen Su, Hau-Ming Wu, Shih-Chung Huang, Yi-Chen Wang, Chien-Yao Wang, Shu-Fang Huang, Yen-Cheng Yeh, Ren-Jy Ben, Shang-Tao Chien, Chin-Wen Hsu, Wu-Hsien Kuo. Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular CarcinomaBioMed Research International 2015; 2015: 1 doi: 10.1155/2015/840542
213
Krista Joanne Callas, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Mayank Gangwar, Snehasis Jana, Jong In Kim. In Vitro Cell-Based Biomarkers Study of Vital Organs: Impact of the Biofield Energy Based Test FormulationJournal of Human Health Research 2019; 1(2): 22 doi: 10.14302/issn.2576-9383.jhhr-19-2945
214
Elisabet Cuyàs, Sara Verdura, Vicente Micol, Jorge Joven, Joaquim Bosch-Barrera, José Antonio Encinar, Javier A. Menendez. Revisiting silibinin as a novobiocin-like Hsp90 C-terminal inhibitor: Computational modeling and experimental validationFood and Chemical Toxicology 2019; 132: 110645 doi: 10.1016/j.fct.2019.110645
215
Nancy Vargas-Mendoza, Ángel Morales-González, Mauricio Morales-Martínez, Marvin A. Soriano-Ursúa, Luis Delgado-Olivares, Eli Mireya Sandoval-Gallegos, Eduardo Madrigal-Bujaidar, Isela Álvarez-González, Eduardo Madrigal-Santillán, José A. Morales-Gonzalez. Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic ApplicationsBiomedicines 2020; 8(5): 122 doi: 10.3390/biomedicines8050122
216
Wonjong Lee, Dong Gun Lee. Potential role of potassium and chloride channels in regulation of silymarin‐induced apoptosis in Candida albicansIUBMB Life 2018; 70(3): 197 doi: 10.1002/iub.1716
217
Ching-Yun Hsu, Chun-Han Chen, Ibrahim A Aljuffali, You-Shan Dai, Jia-You Fang. Nanovesicle delivery to the liver via retinol binding protein and platelet-derived growth factor receptors: how targeting ligands affect biodistributionNanomedicine 2017; 12(4): 317 doi: 10.2217/nnm-2016-0319
218
Camila R. Ferraz, Thacyana T. Carvalho, Marília F. Manchope, Nayara A. Artero, Fernanda S. Rasquel-Oliveira, Victor Fattori, Rubia Casagrande, Waldiceu A. Verri. Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical DevelopmentMolecules 2020; 25(3): 762 doi: 10.3390/molecules25030762
219
Araylim N. Aralbaeva, Aigul T. Mamataeva, Nazgul I. Zhaparkulova, Raisa S. Utegalieva, Marina Khanin, Michael Danilenko, Maira K. Murzakhmetova. A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicityBiomedicine & Pharmacotherapy 2017; 96: 1283 doi: 10.1016/j.biopha.2017.11.085
220
Anroop B. Nair, Pooja Dalal, Varsha Kadian, Sunil Kumar, Minakshi Garg, Rekha Rao, Rashed M. Almuqbil, Ahmed S. Alnaim, Bandar Aldhubiab, Fatemah Alqattan. Formulation Strategies for Enhancing Pharmaceutical and Nutraceutical Potential of Sesamol: A Natural Phenolic BioactivePlants 2023; 12(5): 1168 doi: 10.3390/plants12051168
221
Dary Mendoza, Juan Pablo Arias, Olmedo Cuaspud, Orlando Ruiz, Mario Arias. FT-NIR spectroscopy and RP-HPLC combined with multivariate analysis reveals differences in plant cell suspension cultures of Thevetia peruviana treated with salicylic acid and methyl jasmonateBiotechnology Reports 2020; 27: e00519 doi: 10.1016/j.btre.2020.e00519
222
M. Kasi Reddy, A. Gopala Reddy, B. Kala Kumar, D. Madhuri, G. Boobalan, M. Anudeep Reddy. Protective effect of rutin in comparison to silymarin against induced hepatotoxicity in ratsVeterinary World 2017; 10(1): 74 doi: 10.14202/vetworld.2017.74-80
223
Raj R.V. Binitha, M.A. Shajahan, Jaseer Muhamed, Thapasimuthu V. Anilkumar, S. Premlal, V.C. Indulekha. Hepatoprotective effect of Lobelia alsinoides Lam. in Wistar ratsJournal of Ayurveda and Integrative Medicine 2020; 11(4): 515 doi: 10.1016/j.jaim.2019.04.004
224
Raed Mohammed Ali Al-nuani, Naser Jawad Kadhim. The Effect of Capparis Spinosa L. Plant on the Cytochrome and Glutathione to Reduce the Hepatotoxicity induced by Paracetamol in MiceJournal of Physics: Conference Series 2020; 1664(1): 012121 doi: 10.1088/1742-6596/1664/1/012121
225
Chavdar Savov Pavlov, Taisiya Alekseevna Turankova, Dar'ya Leonidovna Varganova. LIPOSOMAL TECHNOLOGIES FOR SILYBIN DELIVERY TO THE LIVER IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASEUlyanovsk Medico-biological Journal 2023; (1): 50 doi: 10.34014/2227-1848-2023-1-50-62
226
Chien-Hao Huang, Victor Chien-Chia Wu, Chun-Li Wang, Chia-Ling Wu, Yu-Tung Huang, Shang-Hung Chang. Silymarin Synergizes with Antiviral Therapy in Hepatitis B Virus-Related Liver Cirrhosis: A Propensity Score Matching Multi-Institutional StudyInternational Journal of Molecular Sciences 2024; 25(6): 3088 doi: 10.3390/ijms25063088
227
Tina M. St. John. Integrative Medicine2018; : 198 doi: 10.1016/B978-0-323-35868-2.00021-9
228
Xing-Xing Zhu, Ya-Hui Ding, Yi Wu, Lin-Yan Qian, Hai Zou, Qiang He. Silibinin: a potential old drug for cancer therapyExpert Review of Clinical Pharmacology 2016; 9(10): 1323 doi: 10.1080/17512433.2016.1208563
229
Danjun Guo, Yan Zhang, Juanjuan Zhao, Hui He, Tao Hou. Selenium-biofortified corn peptides: Attenuating concanavalin A—Induced liver injury and structure characterizationJournal of Trace Elements in Medicine and Biology 2019; 51: 57 doi: 10.1016/j.jtemb.2018.09.010
230
M. Saeed, D. Babazadeh, M. Arif, M.A. Arain, Z.A. Bhutto, A.H. Shar, M.U. Kakar, R. Manzoor, S. Chao. Silymarin: a potent hepatoprotective agent in poultry industryWorld's Poultry Science Journal 2017; 73(3): 483 doi: 10.1017/S0043933917000538
231
Mustafa B. A. Djamgoz, Valerie Jentzsch. Integrative Management of Pancreatic Cancer (PDAC): Emerging Complementary Agents and ModalitiesNutrition and Cancer 2022; 74(4): 1139 doi: 10.1080/01635581.2021.1934043
232
Sha Li, Hor-Yue Tan, Ning Wang, Yigang Feng, Xuanbin Wang, Yibin Feng. Recent Insights Into the Role of Immune Cells in Alcoholic Liver DiseaseFrontiers in Immunology 2019; 10 doi: 10.3389/fimmu.2019.01328
233
Yaschilal Muche Belayneh, Getnet Mengistu, Kidan Hailay. Evaluation of hepatoprotective and antidiarrheal activities of the hydromethanol crude extract and solvent fractions of Schinus molle L. (Anacardiaceae) leaf and fruit in miceMetabolism Open 2024; 21: 100272 doi: 10.1016/j.metop.2024.100272
234
Almudena Pérez-Sánchez, Elisabet Cuyàs, Verónica Ruiz-Torres, Luz Agulló-Chazarra, Sara Verdura, Isabel González-Álvarez, Marival Bermejo, Jorge Joven, Vicente Micol, Joaquim Bosch-Barrera, Javier Menendez. Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell MonolayersInternational Journal of Molecular Sciences 2019; 20(7): 1606 doi: 10.3390/ijms20071606
235
Mehdi Koushki, Reyhaneh Farrokhi Yekta, Nasrin Amiri-Dashatan. Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoidJournal of Functional Foods 2023; 104: 105502 doi: 10.1016/j.jff.2023.105502
236
Young Chul Kim, Jong Deok Na, Do Young Kwon, Jae Hak Park. Silymarin prevents acetaminophen-induced hepatotoxicity via up-regulation of the glutathione conjugation capacity in miceJournal of Functional Foods 2018; 49: 235 doi: 10.1016/j.jff.2018.08.025
237
Xiangpeng Wang, Lulu Wu, Quanshu Zhang, Lili Li, Yanni Xie, Xing Wan, Hao Wu, Yang Xiang. Methyl 3,4-dihydroxybenzoate protects against d-galN/LPS-induced acute liver injury by inhibiting inflammation and apoptosis in miceJournal of Pharmacy and Pharmacology 2019; 71(7): 1082 doi: 10.1111/jphp.13091
238
Ahmed M. Sayed, Emad H.M. Hassanein, Shimaa H. Salem, Omnia E. Hussein, Ayman M. Mahmoud. Flavonoids-mediated SIRT1 signaling activation in hepatic disordersLife Sciences 2020; 259: 118173 doi: 10.1016/j.lfs.2020.118173
239
Dahryn Trivedi, Snehasis Jana. Assessment of Biofield Energy Treatment on Liver Health Using Hepatocellular Carcinoma Cell Line (HepG2)Journal of Gastrointestinal Disorders and Liver function 2018; 4(1): 17 doi: 10.15436/2471-0601.18.2006
240
Drug Discovery from Mother NatureAdvances in Experimental Medicine and Biology 2016; 929: 25 doi: 10.1007/978-3-319-41342-6_2
241
Josif Vidimce, Evan Noel Pennell, Maxmilian Foo, Ryan Graeme Shiels, Sapha Shibeeb, Michael Watson, Andrew Cameron Bulmer. Effect of Silymarin Treatment on Circulating Bilirubin and Cardiovascular Disease Risk Factors in Healthy Men: A Single‐Blind, Randomized Crossover TrialClinical Pharmacology in Drug Development 2021; 10(10): 1156 doi: 10.1002/cpdd.962
242
Katia Azarfar, Parichehreh Yaghmaei, Mahsa M. Amoli, Nasim Hayati-Roodbari, Azadeh Ebrahim-Habibi. Local Insulin-Derived Amyloidosis Model Confronted with Silymarin: Histological Insights and Gene Expression of MMP, TNF-α, and IL-6International Journal of Molecular Sciences 2022; 23(9): 4952 doi: 10.3390/ijms23094952
243
Kyung Do Kim, Jeehyoung Shim, Ji-Hun Hwang, Daegwan Kim, Moaine El Baidouri, Soyeon Park, Jiyong Song, Yeisoo Yu, Keunpyo Lee, Byoung-Ohg Ahn, Su Young Hong, Joong Hyoun Chin. Chromosome-level genome assembly of milk thistle (Silybum marianum (L.) Gaertn.)Scientific Data 2024; 11(1) doi: 10.1038/s41597-024-03178-3
244
Nafiseh Esmaeil, Sima Balouchi Anaraki, Marjan Gharagozloo, Behjat Moayedi. Silymarin impacts on immune system as an immunomodulator: One key for many locksInternational Immunopharmacology 2017; 50: 194 doi: 10.1016/j.intimp.2017.06.030
245
Yao Zhu, Xiangli Zhang, Pengfei Du, Ziyang Wang, Pengna Luo, Yanqun Huang, Zhenhua Liu, Huaiyong Zhang, Wen Chen. Dietary herbaceous mixture supplementation reduced hepatic lipid deposition and improved hepatic health status in post-peak laying hensPoultry Science 2022; 101(6): 101870 doi: 10.1016/j.psj.2022.101870
246
Vladimir Mihailović, Nikola Srećković, Jelena B. Popović-Djordjević. Handbook of Dietary Flavonoids2023; : 1 doi: 10.1007/978-3-030-94753-8_20-1
247
Godswill N. Anyasor, Damilola P. Idowu, Williams Nabofa. Evaluation of the hepatoprotective effect of oral administration of aqueous fraction of methanolic extract of Costus afer leaves during induction of hepatocellular carcinoma with diethylnitrosamine in ratsComparative Clinical Pathology 2020; 29(3): 733 doi: 10.1007/s00580-020-03124-w
248
Sidra Ihsan, Syeda Mariam Hasany, Sumia Akram, Ahmad Adnan, Muhammad Mushtaq. A Centum of Valuable Plant Bioactives2021; : 445 doi: 10.1016/B978-0-12-822923-1.00003-0
249
Tae-Won Kim, Dong-Ryung Lee, Bong-Keun Choi, Hwan-Kyu Kang, Ju-Young Jung, Seol-Wa Lim, Seung Hwan Yang, Joo-Won Suh. Hepatoprotective effects of polymethoxyflavones against acute and chronic carbon tetrachloride intoxicationFood and Chemical Toxicology 2016; 91: 91 doi: 10.1016/j.fct.2016.03.004
250
Eun-Sun Choi, Sejun Oh, Boonsil Jang, Hyun-Ju Yu, Ji-Ae Shin, Nam-Pyo Cho, In-Hyoung Yang, Dong-Hoon Won, Hye-Jeong Kwon, Seong Doo Hong, Sung-Dae Cho. Silymarin and its active component silibinin act as novel therapeutic alternatives for salivary gland cancer by targeting the ERK1/2-Bim signaling cascadeCellular Oncology 2017; 40(3): 235 doi: 10.1007/s13402-017-0318-8
251
Hany Elsawy, Abdullah M. Alzahrani, Manal Alfwuaires, Azza Sedky, Eman E. El- Trass, Omar Mahmoud, Ashraf M. Abdel-Moneim, Mahmoud Khalil. Analysis of silymarin-modulating effects against acrylamide-induced cerebellar damage in male rats: Biochemical and pathological markersJournal of Chemical Neuroanatomy 2021; 115: 101964 doi: 10.1016/j.jchemneu.2021.101964
252
Jun Liang, Ying Liu, Jinguang Liu, Zhe Li, Qiangyuan Fan, Zifei Jiang, Fei Yan, Zhi Wang, Peiwen Huang, Nianping Feng. Chitosan-functionalized lipid-polymer hybrid nanoparticles for oral delivery of silymarin and enhanced lipid-lowering effect in NAFLDJournal of Nanobiotechnology 2018; 16(1) doi: 10.1186/s12951-018-0391-9