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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Focal liver lesions: Practical magnetic resonance imaging approach  
António P Matos, Fernanda Velloni, Miguel Ramalho, Mamdoh AlObaidy, Aruna Rajapaksha, Richard C Semelka 
World J Hepatol 7(16):1987-2008. Published online Aug 8, 2015. doi: 10.4254/wjh.v7.i16.1987
2
Current status of imaging in nonalcoholic fatty liver disease  
Qian Li, Manish Dhyani, Joseph R Grajo, Claude Sirlin, Anthony E Samir 
World J Hepatol 10(8):530-542. Published online Aug 27, 2018. doi: 10.4254/wjh.v10.i8.530
3
Abnormal liver enzymes: A review for clinicians  
Luis Chavez, Monica Leon, Pahnwat Tonya Taweesedt, Salim Surani, M Ammar Kalas 
World J Hepatol 13(11):1688-1698. Published online Nov 27, 2021. doi: 10.4254/wjh.v13.i11.1688
4
Herbalife hepatotoxicity: Evaluation of cases with positive reexposure tests  
Rolf Teschke, Christian Frenzel, Johannes Schulze, Alexander Schwarzenboeck, Axel Eickhoff 
World J Hepatol 5(7):353-363. Published online Jul 27, 2013. doi: 10.4254/wjh.v5.i7.353
5
Vitamin D deficiency in chronic liver disease  
Paula Iruzubieta, Álvaro Terán, Javier Crespo, Emilio Fábrega 
World J Hepatol 6(12):901-915. Published online Dec 27, 2014. doi: 10.4254/wjh.v6.i12.901
6
Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs  
Philip Augustine, Meera Mohanan, Tom George, Sasidharan Rajesh, Rizwan Ahamed, Cyriac Abby Philips 
World J Hepatol 12(9):574-595. Published online Sep 27, 2020. doi: 10.4254/wjh.v12.i9.574
7
Hepatitis C virus: Morphogenesis, infection and therapy  
Vladimir Alexei Morozov, Sylvie Lagaye 
World J Hepatol 10(2):186-212. Published online Feb 27, 2018. doi: 10.4254/wjh.v10.i2.186
8
Non-alcoholic fatty liver disease: The diagnosis and management  
Eman M Salah El-Den Ashmawy, Shehab M Abd El-Kader 
World J Hepatol 7(6):846-858. Published online Apr 28, 2015. doi: 10.4254/wjh.v7.i6.846
9
Acute liver injury induced by weight-loss herbal supplements  
Gary C Chen, Vivek S Ramanathan, David Law, Pauline Funchain, George C Chen, Samuel French, Boris Shlopov, Viktor Eysselein, David Chung, Sonya Reicher, Binh V Pham 
World J Hepatol 2(11):410-415. Published online Nov 27, 2010. doi: 10.4254/wjh.v2.i11.410
10
11
Genetic diversity of hepatitis viruses in West-African countries from 1996 to 2018  
Jacques Simpore, Simplice Karou, Florencia Wendkuuni Djigma, Dorcas Obiri-Yeboah, Tegwindé Rebeca Compaore, Albert Theophane Yonli, Birama Diarra, Abdoul Karim Ouattara, Maléki Assih 
World J Hepatol 10(11):807-821. Published online Nov 27, 2018. doi: 10.4254/wjh.v10.i11.807
12
Portal hypertensive gastropathy: A systematic review of the pathophysiology, clinical presentation, natural history and therapy  
Mihajlo Gjeorgjievski, Mitchell S Cappell 
World J Hepatol 8(4):231-262. Published online Feb 8, 2016. doi: 10.4254/wjh.v8.i4.231
13
14
Staging of liver fibrosis or cirrhosis: The role of hepatic venous pressure gradient measurement  
Ki Tae Suk, Dong Joon Kim 
World J Hepatol 7(3):607-615. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.607
15
Wilson’s disease: A review of what we have learned  
Kryssia Isabel Rodriguez-Castro, Francisco Javier Hevia-Urrutia, Giacomo Carlo Sturniolo 
World J Hepatol 7(29):2859-2870. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2859
16
MR with Gd-EOB-DTPA in assessment of liver nodules in cirrhotic patients  
Davide Ippolito, Anna Pecorelli, Marco Gatti, Eleonora Tricarico, Luigi Grazioli, Riccardo Faletti, Riccardo Inchingolo 
World J Hepatol 10(7):462-473. Published online Jul 27, 2018. doi: 10.4254/wjh.v10.i7.462
17
Clinical implications, diagnosis, and management of diabetes in patients with chronic liver diseases  
Waihong Chung, Kittichai Promrat, Jack Wands 
World J Hepatol 12(9):533-557. Published online Sep 27, 2020. doi: 10.4254/wjh.v12.i9.533
18
Hepatocellular carcinoma in non-cirrhotic liver: A comprehensive review  
Dalbir Singh Sandhu, Jin-Ping Lai, Sonia Sandhu, Aakash Desai 
World J Hepatol 11(1):1-18. Published online Jan 27, 2019. doi: 10.4254/wjh.v11.i1.1
19
Hepatitis C virus: Virology, diagnosis and treatment  
Hui-Chun Li, Shih-Yen Lo 
World J Hepatol 7(10):1377-1389. Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1377
20
Liver injury induced by paracetamol and challenges associated with intentional and unintentional use  
Laura Rotundo, Nikolaos Pyrsopoulos 
World J Hepatol 12(4):125-136. Published online Apr 27, 2020. doi: 10.4254/wjh.v12.i4.125
21
Bacterial infections in cirrhosis: A critical review and practical guidance  
Chalermrat Bunchorntavakul, Naichaya Chamroonkul, Disaya Chavalitdhamrong 
World J Hepatol 8(6):307-321. Published online Feb 28, 2016. doi: 10.4254/wjh.v8.i6.307
22
Current status of diagnosis and treatment of hepatic echinococcosis  
Emre Bozkurt, Sinan Omeroglu, Ozgur Bostanci, Uygar Demir, Cemal Kaya, Ufuk Oguz Idiz, Memmet Mihmanli 
World J Hepatol 8(28):1169-1181. Published online Oct 8, 2016. doi: 10.4254/wjh.v8.i28.1169
23
Hepatitis C virus genetic variability and evolution  
Natalia Echeverría, Gonzalo Moratorio, Juan Cristina, Pilar Moreno 
World J Hepatol 7(6):831-845. Published online Apr 28, 2015. doi: 10.4254/wjh.v7.i6.831
24
Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease  
Mustafa Koplay, Mesut Sivri, Hasan Erdogan, Alaaddin Nayman 
World J Hepatol 7(5):769-776. Published online Apr 18, 2015. doi: 10.4254/wjh.v7.i5.769
25
Liver failure caused by prolonged state of malnutrition following bariatric surgery  
Janneke Wiebolt, Jan A Apers, Antonie JP van Tilburg, Willem J Lammers 
World J Hepatol 10(3):396-399. Published online Mar 27, 2018. doi: 10.4254/wjh.v10.i3.396
26
Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside  
Bing Hu, Shuang-Shuang Wang, Qin Du 
World J Hepatol 7(9):1209-1232. Published online May 28, 2015. doi: 10.4254/wjh.v7.i9.1209
27
Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy  
Michael Feigh, Niels Vrang, Jacob Jelsing, Jonathan David Roth, Kirstine Sloth Tølbøl, Kristoffer Tobias Gustav Rigbolt, Sanne Skovgård Veidal, Maria Nicoline Baandrup Kristiansen 
World J Hepatol 8(16):673-684. Published online Jun 8, 2016. doi: 10.4254/wjh.v8.i16.673
28
Benign focal liver lesions: The role of magnetic resonance imaging  
Riccardo Faletti, Davide Ippolito, Riccardo Inchingolo, Eleonora Tricarico, Fatemeh Darvizeh, Andrea Carisio, Davide Tore, Cesare Maino, Marco Gatti 
World J Hepatol 14(5):923-943. Published online May 27, 2022. doi: 10.4254/wjh.v14.i5.923
29
Prediction of liver cirrhosis, using diagnostic imaging tools  
Suk Keu Yeom, Chang Hee Lee, Sang Hoon Cha, Cheol Min Park 
World J Hepatol 7(17):2069-2079. Published online Aug 18, 2015. doi: 10.4254/wjh.v7.i17.2069
30
Hepatoprotective effect of silymarin  
José A Morales-González, Juan A Gayosso-de-Lucio, Manuel García-Luna y González-Rubio, Cesar Esquivel-Chirino, Jaime Esquivel-Soto, Ángel Morales-González, Eduardo Madrigal-Santillán, Nancy Vargas-Mendoza 
World J Hepatol 6(3):144-149. Published online Mar 27, 2014. doi: 10.4254/wjh.v6.i3.144
31
Terpenoids as potential chemopreventive and therapeutic agents in liver cancer  
Anupam Bishayee, Roslin J Thoppil 
World J Hepatol 3(9):228-249. Published online Sep 27, 2011. doi: 10.4254/wjh.v3.i9.228
32
Review on immunosuppression in liver transplantation  
Maryam Moini, Michael L Schilsky, Eric M Tichy 
World J Hepatol 7(10):1355-1368. Published online Jun 8, 2015. doi: 10.4254/wjh.v7.i10.1355
33
Cystic echinococcosis of the liver: A primer for hepatologists  
Francesca Rinaldi, Enrico Brunetti, Andreas Neumayr, Marcello Maestri, Samuel Goblirsch, Francesca Tamarozzi 
World J Hepatol 6(5):293-305. Published online May 27, 2014. doi: 10.4254/wjh.v6.i5.293
34
Vascular complications following liver transplantation: A literature review of advances in 2015  
Tullio Piardi, Martin Lhuaire, Onorina Bruno, Riccardo Memeo, Patrick Pessaux, Reza Kianmanesh, Daniele Sommacale 
World J Hepatol 8(1):36-57. Published online Jan 8, 2016. doi: 10.4254/wjh.v8.i1.36
35
Concept of the pathogenesis and treatment of cholelithiasis  
Vasiliy Ivanovich Reshetnyak 
World J Hepatol 4(2):18-34. Published online Feb 27, 2012. doi: 10.4254/wjh.v4.i2.18
36
PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis  
Linda Pasta, Francesca Pasta 
World J Hepatol 7(29):2920-2926. Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2920
37
Cholesterol metabolism in cholestatic liver disease and liver transplantation: From molecular mechanisms to clinical implications  
Helena Isoniemi, Helena Gylling, Fredrik Åberg, Katriina Nemes 
World J Hepatol 8(22):924-932. Published online Aug 8, 2016. doi: 10.4254/wjh.v8.i22.924
38
Clinical algorithms for the prevention of variceal bleeding and rebleeding in patients with liver cirrhosis  
Thomas Reiberger, Lukas W Unger, Nikolaus Pfisterer 
World J Hepatol 13(7):731-746. Published online Jul 27, 2021. doi: 10.4254/wjh.v13.i7.731
39
Herbal Traditional Chinese Medicine and suspected liver injury: A prospective study  
Dieter Melchart, Stefan Hager, Sabine Albrecht, Jingzhang Dai, Wolfgang Weidenhammer, Rolf Teschke 
World J Hepatol 9(29):1141-1157. Published online Oct 18, 2017. doi: 10.4254/wjh.v9.i29.1141
40
Guide for diagnosis and treatment of hepatocellular carcinoma  
Shahira Aly El-Etreby, Magdy Hamed Attwa 
World J Hepatol 7(12):1632-1651. Published online Jun 28, 2015. doi: 10.4254/wjh.v7.i12.1632
41
42
Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice  
Kandy T Velázquez, Reilly T Enos, Jackie E Bader, Alexander T Sougiannis, Meredith S Carson, Ioulia Chatzistamou, James A Carson, Prakash S Nagarkatti, Mitzi Nagarkatti, E Angela Murphy 
World J Hepatol 11(8):619-637. Published online Aug 27, 2019. doi: 10.4254/wjh.v11.i8.619
43
Life cycle and pathogenesis of hepatitis D virus: A review  
Zaigham Abbas, Rafia Afzal 
World J Hepatol 5(12):666-675. Published online Dec 27, 2013. doi: 10.4254/wjh.v5.i12.666
44
Hepatitis C virus syndrome: A constellation of organ- and non-organ specific autoimmune disorders, B-cell non-Hodgkin’s lymphoma, and cancer  
Clodoveo Ferri, Marco Sebastiani, Dilia Giuggioli, Michele Colaci, Poupak Fallahi, Alessia Piluso, Alessandro Antonelli, Anna Linda Zignego 
World J Hepatol 7(3):327-343. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.327
45
Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease  
Vanessa Souza-Mello 
World J Hepatol 7(8):1012-1019. Published online May 18, 2015. doi: 10.4254/wjh.v7.i8.1012
46
One stop shop approach for the diagnosis of liver hemangioma  
Larisa Daniela Sandulescu, Cristiana Marinela Urhut, Sarmis Marian Sandulescu, Ana-Maria Ciurea, Sergiu Marian Cazacu, Sevastita Iordache 
World J Hepatol 13(12):1892-1908. Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.1892
47
Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy  
Mitchell S Cappell, Treta Purohit 
World J Hepatol 7(7):926-941. Published online May 8, 2015. doi: 10.4254/wjh.v7.i7.926
48
Gut-liver axis in liver cirrhosis: How to manage leaky gut and endotoxemia  
Hiroshi Fukui 
World J Hepatol 7(3):425-442. Published online Mar 27, 2015. doi: 10.4254/wjh.v7.i3.425
49
Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis  
Daniela Campion, Ilaria Giovo, Paola Ponzo, Giorgio M Saracco, Federico Balzola, Carlo Alessandria 
World J Hepatol 11(6):489-512. Published online Jun 27, 2019. doi: 10.4254/wjh.v11.i6.489
50
Risk of liver disease in methotrexate treated patients  
Richard Conway, John J Carey 
World J Hepatol 9(26):1092-1100. Published online Sep 18, 2017. doi: 10.4254/wjh.v9.i26.1092
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