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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
Fluoxetine induces cytotoxic endoplasmic reticulum stress and autophagy in triple negative breast cancer  
Michelle Bowie, Patrick Pilie, Julia Wulfkuhle, Siya Lem, Abigail Hoffman, Shraddha Desai, Emanuel Petricoin, Amira Carter, Adrian Ambrose, Victoria Seewaldt, Dihua Yu, Catherine Ibarra Drendall 
World J Clin Oncol 6(6):299-311. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.299
Magnetic resonance imaging for diagnosis and neoadjuvant treatment evaluation in locally advanced rectal cancer: A pictorial review  
Gulgun Engin, Rasul Sharifov 
World J Clin Oncol 8(3):214-229. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.214
Pathogenesis, prevention, diagnosis and treatment of breast cancer  
Rupen Shah, Kelly Rosso, S David Nathanson 
World J Clin Oncol 5(3):283-298. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.283
Long-term stabilization of metastatic melanoma with sodium dichloroacetate  
Akbar Khan, Doug Andrews, Jill Shainhouse, Anneke C Blackburn 
World J Clin Oncol 8(4):371-377. Published online Aug 10, 2017. doi: 10.5306/wjco.v8.i4.371
Paraneoplastic syndromes associated with lung cancer  
Nobuhiro Kanaji, Naoki Watanabe, Nobuyuki Kita, Shuji Bandoh, Akira Tadokoro, Tomoya Ishii, Hiroaki Dobashi, Takuya Matsunaga 
World J Clin Oncol 5(3):197-223. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.197
Inorganic phosphate in the development and treatment of cancer: A Janus Bifrons?  
Luigi Sapio, Silvio Naviglio 
World J Clin Oncol 6(6):198-201. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.198
Biological subtypes of breast cancer: Prognostic and therapeutic implications  
Ozlem Yersal, Sabri Barutca 
World J Clin Oncol 5(3):412-424. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.412
Exploiting the homologous recombination DNA repair network for targeted cancer therapy  
Guang Peng, Shiaw-Yih Lin 
World J Clin Oncol 2(2):73-79. Published online Feb 10, 2011. doi: 10.5306/wjco.v2.i2.73
Overview, prevention and management of chemotherapy extravasation  
Firas Y Kreidieh, Hiba A Moukadem, Nagi S El Saghir 
World J Clin Oncol 7(1):87-97. Published online Feb 10, 2016. doi: 10.5306/wjco.v7.i1.87
Objective response rate assessment in oncology: Current situation and future expectations  
Nuri Faruk Aykan, Tahsin Özatlı 
World J Clin Oncol 11(2):53-73. Published online Feb 24, 2020. doi: 10.5306/wjco.v11.i2.53
Plasma cell leukemia - one in a million: A case report  
Akriti G Jain, Mohammed Faisal-Uddin, Abdul K Khan, Mohammed Wazir, Qi Shen, Manoucher Manoucheri 
World J Clin Oncol 10(3):161-165. Published online Mar 24, 2019. doi: 10.5306/wjco.v10.i3.161
High intensity focused ultrasound in clinical tumor ablation  
Yu-Feng Zhou 
World J Clin Oncol 2(1):8-27. Published online Jan 10, 2011. doi: 10.5306/wjco.v2.i1.8
Three-dimensional bio-printing: A new frontier in oncology research  
Nitin Charbe, Paul A McCarron, Murtaza M Tambuwala 
World J Clin Oncol 8(1):21-36. Published online Feb 10, 2017. doi: 10.5306/wjco.v8.i1.21
Biomarkers in triple negative breast cancer: A review  
Budhi S Yadav, Priyanka Chanana, Swaty Jhamb 
World J Clin Oncol 6(6):252-263. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.252
Role of the microbiome in non-gastrointestinal cancers  
Meirav Pevsner-Fischer, Timur Tuganbaev, Mariska Meijer, Sheng-Hong Zhang, Zhi-Rong Zeng, Min-Hu Chen, Eran Elinav 
World J Clin Oncol 7(2):200-213. Published online Apr 10, 2016. doi: 10.5306/wjco.v7.i2.200
Bethesda System for Reporting Thyroid Cytopathology: A three-year study at a tertiary care referral center in Saudi Arabia  
Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert, Aljuboury Muna, Alkharashi Eyad, Abdullah Al Ghamdi, Khalid Al Hajeri, Mohammed A Thabet, Rim Braham 
World J Clin Oncol 8(2):151-157. Published online Apr 10, 2017. doi: 10.5306/wjco.v8.i2.151
Colon cancer and the epidermal growth factor receptor: Current treatment paradigms, the importance of diet, and the role of chemoprevention  
Baldeep Pabla, Marc Bissonnette, Vani J Konda 
World J Clin Oncol 6(5):133-141. Published online Oct 10, 2015. doi: 10.5306/wjco.v6.i5.133
Cervical cancer screening in developing countries at a crossroad: Emerging technologies and policy choices  
Rosa Catarino, Patrick Petignat, Gabriel Dongui, Pierre Vassilakos 
World J Clin Oncol 6(6):281-290. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.281
Nephrotoxicity in cancer treatment: An overview  
Maria Luísa Cordeiro Santos, Breno Bittencourt de Brito, Filipe Antônio França da Silva, Anelise Costa dos Santos Botelho, Fabrício Freire de Melo 
World J Clin Oncol 11(4):190-204. Published online Apr 24, 2020. doi: 10.5306/wjco.v11.i4.190
Imaging of gastroenteropancreatic neuroendocrine tumors  
Eik Hock Tan, Cher Heng Tan 
World J Clin Oncol 2(1):28-43. Published online Jan 10, 2011. doi: 10.5306/wjco.v2.i1.28
Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas  
Eva Wimmer, Stephan Ihrler, Olivier Gires, Sylvia Streit, Wolfgang Issing, Christoph Bergmann 
World J Clin Oncol 10(3):136-148. Published online Mar 24, 2019. doi: 10.5306/wjco.v10.i3.136
Study of recombinant human interleukin-12 for treatment of complications after radiotherapy for tumor patients  
Na Guo, Wen-Qin Wang, Xiao-Jing Gong, Lei Gao, Li-Rong Yang, Wei-Na Yu, Hong-Yu Shen, Ling-Qin Wan, Xi-Feng Jia, Yi-Shan Wang, Yi Zhao 
World J Clin Oncol 8(2):158-167. Published online Apr 10, 2017. doi: 10.5306/wjco.v8.i2.158
Targeting metabolism in breast cancer: How far we can go?  
Jing-Pei Long, Xiao-Na Li, Feng Zhang 
World J Clin Oncol 7(1):122-130. Published online Feb 10, 2016. doi: 10.5306/wjco.v7.i1.122
Review of anticancer mechanisms of isoquercitin  
Guilherme di Camillo Orfali, Ana Carolina Duarte, Vivien Bonadio, Natalia Peres Martinez, Maria Elisa Melo Branco de Araújo, Fernanda Bruschi Marinho Priviero, Patricia Oliveira Carvalho, Denise Gonçalves Priolli 
World J Clin Oncol 7(2):189-199. Published online Apr 10, 2016. doi: 10.5306/wjco.v7.i2.189
Challenges to the early diagnosis and treatment of breast cancer in developing countries  
Karla Unger-Saldaña 
World J Clin Oncol 5(3):465-477. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.465
Sentinel lymph node mapping of a breast cancer of the vulva: Case report and literature review  
James Cripe, Ramez Eskander, Krishnansu Tewari 
World J Clin Oncol 6(2):16-21. Published online Apr 10, 2015. doi: 10.5306/wjco.v6.i2.16
Hong Kong female’s breast cancer awareness measure: Cross-sectional survey  
May Pui Shan Yeung, Emily Ying Yang Chan, Samuel Yeung Shan Wong, Benjamin Hon Kei Yip, Polly Suk-Yee Cheung 
World J Clin Oncol 10(2):98-109. Published online Feb 24, 2019. doi: 10.5306/wjco.v10.i2.98
Cell-free DNA integrity for the monitoring of breast cancer: Future perspectives?  
Navid Sobhani, Daniele Generali, Fabrizio Zanconati, Marina Bortul, Bruna Scaggiante 
World J Clin Oncol 9(2):26-32. Published online Apr 10, 2018. doi: 10.5306/wjco.v9.i2.26
Immunotherapy in pancreatic cancer: Unleash its potential through novel combinations  
Songchuan Guo, Merly Contratto, George Miller, Lawrence Leichman, Jennifer Wu 
World J Clin Oncol 8(3):230-240. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.230
Palliative surgery for Krukenberg tumors – 12-year experience and review of the literature  
Isaac Seow-En, Gwen Hwarng, Grace Hwei Ching Tan, Leonard Ming Li Ho, Melissa Ching Ching Teo 
World J Clin Oncol 9(1):13-19. Published online Feb 10, 2018. doi: 10.5306/wjco.v9.i1.13
Evolving role of Sorafenib in the management of hepatocellular carcinoma  
Ioannis A Ziogas, Georgios Tsoulfas 
World J Clin Oncol 8(3):203-213. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.203
Existing anti-angiogenic therapeutic strategies for patients with metastatic colorectal cancer progressing following first-line bevacizumab-based therapy  
Ozkan Kanat, Hulya Ertas 
World J Clin Oncol 10(2):52-61. Published online Feb 24, 2019. doi: 10.5306/wjco.v10.i2.52
Immediate nipple-areola-sparing mastectomy reconstruction: An update on oncological and reconstruction techniques  
Alexandre Mendonça Munhoz, Eduardo Montag, José Roberto Filassi, Rolf Gemperli 
World J Clin Oncol 5(3):478-494. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.478
Cyclooxygenase-2 and the inflammogenesis of breast cancer  
Randall E Harris, Bruce C Casto, Zachary M Harris 
World J Clin Oncol 5(4):677-692. Published online Oct 10, 2014. doi: 10.5306/wjco.v5.i4.677
Multidisciplinary approach of colorectal cancer liver metastases  
Giammaria Fiorentini, Donatella Sarti, Camillo Aliberti, Riccardo Carandina, Andrea Mambrini, Stefano Guadagni 
World J Clin Oncol 8(3):190-202. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.190
Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer  
Cynthia I Tchio Mantho, Adriana Harbuzariu, Ruben R Gonzalez-Perez 
World J Clin Oncol 8(3):178-189. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.178
Biological mesh reconstruction of the pelvic floor following abdominoperineal excision for cancer: A review  
Boris Schiltz, Nicolas Christian Buchs, Marta Penna, Cosimo Riccardo Scarpa, Emilie Liot, Philippe Morel, Frederic Ris 
World J Clin Oncol 8(3):249-254. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.249
Nanoparticle-linked antagonist for leptin signaling inhibition in breast cancer  
Tia Harmon, Adriana Harbuzariu, Viola Lanier, Crystal C Lipsey, Ward Kirlin, Lily Yang, Ruben R Gonzalez-Perez 
World J Clin Oncol 8(1):54-66. Published online Feb 10, 2017. doi: 10.5306/wjco.v8.i1.54
Therapeutic management options for stage III non-small cell lung cancer  
Stephanie M Yoon, Talha Shaikh, Mark Hallman 
World J Clin Oncol 8(1):1-20. Published online Feb 10, 2017. doi: 10.5306/wjco.v8.i1.1
Current therapeutic strategies for advanced pancreatic cancer: A review for clinicians  
Rosella Spadi, Federica Brusa, Agostino Ponzetti, Isabella Chiappino, Nadia Birocco, Libero Ciuffreda, Maria Antonietta Satolli 
World J Clin Oncol 7(1):27-43. Published online Feb 10, 2016. doi: 10.5306/wjco.v7.i1.27
Polyubiquitination inhibition of estrogen receptor alpha and its implications in breast cancer  
Angeles C Tecalco-Cruz, Josué O Ramírez-Jarquín 
World J Clin Oncol 9(4):60-70. Published online Aug 13, 2018. doi: 10.5306/wjco.v9.i4.60
Current state and controversies in fertility preservation in women with breast cancer  
Enes Taylan, Kutluk H Oktay 
World J Clin Oncol 8(3):241-248. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.241
Surgical strategy for bile duct cancer: Advances and current limitations  
Nobuhisa Akamatsu, Yasuhiko Sugawara, Daijo Hashimoto 
World J Clin Oncol 2(2):94-107. Published online Feb 10, 2011. doi: 10.5306/wjco.v2.i2.94
Breast cancer phenotypes regulated by tissue factor-factor VII pathway: Possible therapeutic targets  
Shiro Koizume, Yohei Miyagi 
World J Clin Oncol 5(5):908-920. Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.908
Does low volume high-intensity interval training elicit superior benefits to continuous low to moderate-intensity training in cancer survivors?  
Kellie Toohey, Kate Pumpa, Andrew McKune, Julie Cooke, Katrina D DuBose, Desmond Yip, Paul Craft, Stuart Semple 
World J Clin Oncol 9(1):1-12. Published online Feb 10, 2018. doi: 10.5306/wjco.v9.i1.1