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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
Fluoxetine induces cytotoxic endoplasmic reticulum stress and autophagy in triple negative breast cancer  
Michelle Bowie, Patrick Pilie, Julia Wulfkuhle, Siya Lem, Abigail Hoffman, Shraddha Desai, Emanuel Petricoin, Amira Carter, Adrian Ambrose, Victoria Seewaldt, Dihua Yu, Catherine Ibarra Drendall 
World J Clin Oncol 6(6):299-311. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.299
Inorganic phosphate in the development and treatment of cancer: A Janus Bifrons?  
Luigi Sapio, Silvio Naviglio 
World J Clin Oncol 6(6):198-201. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.198
Magnetic resonance imaging for diagnosis and neoadjuvant treatment evaluation in locally advanced rectal cancer: A pictorial review  
Gulgun Engin, Rasul Sharifov 
World J Clin Oncol 8(3):214-229. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.214
Paraneoplastic syndromes associated with lung cancer  
Nobuhiro Kanaji, Naoki Watanabe, Nobuyuki Kita, Shuji Bandoh, Akira Tadokoro, Tomoya Ishii, Hiroaki Dobashi, Takuya Matsunaga 
World J Clin Oncol 5(3):197-223. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.197
Long-term stabilization of metastatic melanoma with sodium dichloroacetate  
Akbar Khan, Doug Andrews, Jill Shainhouse, Anneke C Blackburn 
World J Clin Oncol 8(4):371-377. Published online Aug 10, 2017. doi: 10.5306/wjco.v8.i4.371
Exploiting the homologous recombination DNA repair network for targeted cancer therapy  
Guang Peng, Shiaw-Yih Lin 
World J Clin Oncol 2(2):73-79. Published online Feb 10, 2011. doi: 10.5306/wjco.v2.i2.73
Pathogenesis, prevention, diagnosis and treatment of breast cancer  
Rupen Shah, Kelly Rosso, S David Nathanson 
World J Clin Oncol 5(3):283-298. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.283
Overview, prevention and management of chemotherapy extravasation  
Firas Y Kreidieh, Hiba A Moukadem, Nagi S El Saghir 
World J Clin Oncol 7(1):87-97. Published online Feb 10, 2016. doi: 10.5306/wjco.v7.i1.87
High intensity focused ultrasound in clinical tumor ablation  
Yu-Feng Zhou 
World J Clin Oncol 2(1):8-27. Published online Jan 10, 2011. doi: 10.5306/wjco.v2.i1.8
Three-dimensional bio-printing: A new frontier in oncology research  
Nitin Charbe, Paul A McCarron, Murtaza M Tambuwala 
World J Clin Oncol 8(1):21-36. Published online Feb 10, 2017. doi: 10.5306/wjco.v8.i1.21
Plasma cell leukemia - one in a million: A case report  
Akriti G Jain, Mohammed Faisal-Uddin, Abdul K Khan, Mohammed Wazir, Qi Shen, Manoucher Manoucheri 
World J Clin Oncol 10(3):161-165. Published online Mar 24, 2019. doi: 10.5306/wjco.v10.i3.161
Role of the microbiome in non-gastrointestinal cancers  
Meirav Pevsner-Fischer, Timur Tuganbaev, Mariska Meijer, Sheng-Hong Zhang, Zhi-Rong Zeng, Min-Hu Chen, Eran Elinav 
World J Clin Oncol 7(2):200-213. Published online Apr 10, 2016. doi: 10.5306/wjco.v7.i2.200
Bethesda System for Reporting Thyroid Cytopathology: A three-year study at a tertiary care referral center in Saudi Arabia  
Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert, Aljuboury Muna, Alkharashi Eyad, Abdullah Al Ghamdi, Khalid Al Hajeri, Mohammed A Thabet, Rim Braham 
World J Clin Oncol 8(2):151-157. Published online Apr 10, 2017. doi: 10.5306/wjco.v8.i2.151
Imaging of gastroenteropancreatic neuroendocrine tumors  
Eik Hock Tan, Cher Heng Tan 
World J Clin Oncol 2(1):28-43. Published online Jan 10, 2011. doi: 10.5306/wjco.v2.i1.28
Study of recombinant human interleukin-12 for treatment of complications after radiotherapy for tumor patients  
Na Guo, Wen-Qin Wang, Xiao-Jing Gong, Lei Gao, Li-Rong Yang, Wei-Na Yu, Hong-Yu Shen, Ling-Qin Wan, Xi-Feng Jia, Yi-Shan Wang, Yi Zhao 
World J Clin Oncol 8(2):158-167. Published online Apr 10, 2017. doi: 10.5306/wjco.v8.i2.158
Sentinel lymph node mapping of a breast cancer of the vulva: Case report and literature review  
James Cripe, Ramez Eskander, Krishnansu Tewari 
World J Clin Oncol 6(2):16-21. Published online Apr 10, 2015. doi: 10.5306/wjco.v6.i2.16
Biomarkers in triple negative breast cancer: A review  
Budhi S Yadav, Priyanka Chanana, Swaty Jhamb 
World J Clin Oncol 6(6):252-263. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.252
Colon cancer and the epidermal growth factor receptor: Current treatment paradigms, the importance of diet, and the role of chemoprevention  
Baldeep Pabla, Marc Bissonnette, Vani J Konda 
World J Clin Oncol 6(5):133-141. Published online Oct 10, 2015. doi: 10.5306/wjco.v6.i5.133
Review of anticancer mechanisms of isoquercitin  
Guilherme di Camillo Orfali, Ana Carolina Duarte, Vivien Bonadio, Natalia Peres Martinez, Maria Elisa Melo Branco de Araújo, Fernanda Bruschi Marinho Priviero, Patricia Oliveira Carvalho, Denise Gonçalves Priolli 
World J Clin Oncol 7(2):189-199. Published online Apr 10, 2016. doi: 10.5306/wjco.v7.i2.189
Immunotherapy in pancreatic cancer: Unleash its potential through novel combinations  
Songchuan Guo, Merly Contratto, George Miller, Lawrence Leichman, Jennifer Wu 
World J Clin Oncol 8(3):230-240. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.230
Immediate nipple-areola-sparing mastectomy reconstruction: An update on oncological and reconstruction techniques  
Alexandre Mendonça Munhoz, Eduardo Montag, José Roberto Filassi, Rolf Gemperli 
World J Clin Oncol 5(3):478-494. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.478
Targeting metabolism in breast cancer: How far we can go?  
Jing-Pei Long, Xiao-Na Li, Feng Zhang 
World J Clin Oncol 7(1):122-130. Published online Feb 10, 2016. doi: 10.5306/wjco.v7.i1.122
Biological subtypes of breast cancer: Prognostic and therapeutic implications  
Ozlem Yersal, Sabri Barutca 
World J Clin Oncol 5(3):412-424. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.412
Cervical cancer screening in developing countries at a crossroad: Emerging technologies and policy choices  
Rosa Catarino, Patrick Petignat, Gabriel Dongui, Pierre Vassilakos 
World J Clin Oncol 6(6):281-290. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.281
Biological mesh reconstruction of the pelvic floor following abdominoperineal excision for cancer: A review  
Boris Schiltz, Nicolas Christian Buchs, Marta Penna, Cosimo Riccardo Scarpa, Emilie Liot, Philippe Morel, Frederic Ris 
World J Clin Oncol 8(3):249-254. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.249
Evolving role of Sorafenib in the management of hepatocellular carcinoma  
Ioannis A Ziogas, Georgios Tsoulfas 
World J Clin Oncol 8(3):203-213. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.203
Current therapeutic strategies for advanced pancreatic cancer: A review for clinicians  
Rosella Spadi, Federica Brusa, Agostino Ponzetti, Isabella Chiappino, Nadia Birocco, Libero Ciuffreda, Maria Antonietta Satolli 
World J Clin Oncol 7(1):27-43. Published online Feb 10, 2016. doi: 10.5306/wjco.v7.i1.27
Surgical strategy for bile duct cancer: Advances and current limitations  
Nobuhisa Akamatsu, Yasuhiko Sugawara, Daijo Hashimoto 
World J Clin Oncol 2(2):94-107. Published online Feb 10, 2011. doi: 10.5306/wjco.v2.i2.94
Multidisciplinary approach of colorectal cancer liver metastases  
Giammaria Fiorentini, Donatella Sarti, Camillo Aliberti, Riccardo Carandina, Andrea Mambrini, Stefano Guadagni 
World J Clin Oncol 8(3):190-202. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.190
Current role of modern radiotherapy techniques in the management of breast cancer  
Gokhan Ozyigit, Melis Gultekin 
World J Clin Oncol 5(3):425-439. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.425
Sentinel lymph node biopsy in clinically detected ductal carcinoma in situ  
Ahmed Yahia Al-Ameer, Sahar Al Nefaie, Badria Al Johani, Ihab Anwar, Taher Al Tweigeri, Asma Tulbah, Mohmmed Alshabanah, Osama Al Malik 
World J Clin Oncol 7(2):258-264. Published online Apr 10, 2016. doi: 10.5306/wjco.v7.i2.258
Therapeutic role of template-based lymphadenectomy in urothelial carcinoma of the upper urinary tract  
Tsunenori Kondo, Toshio Takagi, Kazunari Tanabe 
World J Clin Oncol 6(6):237-251. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.237
Mechanisms and therapeutic advances in the management of endocrine-resistant breast cancer  
Meng Zhao, Bhuvaneswari Ramaswamy 
World J Clin Oncol 5(3):248-262. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.248
Palliative surgery for Krukenberg tumors – 12-year experience and review of the literature  
Isaac Seow-En, Gwen Hwarng, Grace Hwei Ching Tan, Leonard Ming Li Ho, Melissa Ching Ching Teo 
World J Clin Oncol 9(1):13-19. Published online Feb 10, 2018. doi: 10.5306/wjco.v9.i1.13
Effects of psoralens as anti-tumoral agents in breast cancer cells  
Maria Luisa Panno, Francesca Giordano 
World J Clin Oncol 5(3):348-358. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.348
Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer  
Cynthia I Tchio Mantho, Adriana Harbuzariu, Ruben R Gonzalez-Perez 
World J Clin Oncol 8(3):178-189. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.178
Cell-free DNA integrity for the monitoring of breast cancer: Future perspectives?  
Navid Sobhani, Daniele Generali, Fabrizio Zanconati, Marina Bortul, Bruna Scaggiante 
World J Clin Oncol 9(2):26-32. Published online Apr 10, 2018. doi: 10.5306/wjco.v9.i2.26
Nanoparticle-linked antagonist for leptin signaling inhibition in breast cancer  
Tia Harmon, Adriana Harbuzariu, Viola Lanier, Crystal C Lipsey, Ward Kirlin, Lily Yang, Ruben R Gonzalez-Perez 
World J Clin Oncol 8(1):54-66. Published online Feb 10, 2017. doi: 10.5306/wjco.v8.i1.54
Cyclooxygenase-2 and the inflammogenesis of breast cancer  
Randall E Harris, Bruce C Casto, Zachary M Harris 
World J Clin Oncol 5(4):677-692. Published online Oct 10, 2014. doi: 10.5306/wjco.v5.i4.677
Breast cancer phenotypes regulated by tissue factor-factor VII pathway: Possible therapeutic targets  
Shiro Koizume, Yohei Miyagi 
World J Clin Oncol 5(5):908-920. Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.908
Integrating palliative care in oncologic emergency departments: Challenges and opportunities  
Ahmed F Elsayem, Hiba E Elzubeir, Patricia A Brock, Knox H Todd 
World J Clin Oncol 7(2):227-233. Published online Apr 10, 2016. doi: 10.5306/wjco.v7.i2.227
Targeting Enhancer of Zeste Homolog 2 as a promising strategy for cancer treatment  
Irene Marchesi, Luigi Bagella 
World J Clin Oncol 7(2):135-148. Published online Apr 10, 2016. doi: 10.5306/wjco.v7.i2.135
Challenges to the early diagnosis and treatment of breast cancer in developing countries  
Karla Unger-Saldaña 
World J Clin Oncol 5(3):465-477. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.465
IL-6/IL-6R as a potential key signaling pathway in prostate cancer development  
Andreia Azevedo, Virginia Cunha, Ana Luisa Teixeira, Rui Medeiros 
World J Clin Oncol 2(12):384-396. Published online Dec 10, 2011. doi: 10.5306/wjco.v2.i12.384
Advanced oropharyngeal squamous cell carcinoma: Pathogenesis, treatment, and novel therapeutic approaches  
Paul L Swiecicki, Kelly M Malloy, Francis P Worden 
World J Clin Oncol 7(1):15-26. Published online Feb 10, 2016. doi: 10.5306/wjco.v7.i1.15