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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
Pathogenesis, prevention, diagnosis and treatment of breast cancer  
Rupen Shah, Kelly Rosso, S David Nathanson 
World J Clin Oncol 5(3):283-298. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.283
Magnetic resonance imaging for diagnosis and neoadjuvant treatment evaluation in locally advanced rectal cancer: A pictorial review  
Gulgun Engin, Rasul Sharifov 
World J Clin Oncol 8(3):214-229. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.214
Biological subtypes of breast cancer: Prognostic and therapeutic implications  
Ozlem Yersal, Sabri Barutca 
World J Clin Oncol 5(3):412-424. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.412
Fluoxetine induces cytotoxic endoplasmic reticulum stress and autophagy in triple negative breast cancer  
Michelle Bowie, Patrick Pilie, Julia Wulfkuhle, Siya Lem, Abigail Hoffman, Shraddha Desai, Emanuel Petricoin, Amira Carter, Adrian Ambrose, Victoria Seewaldt, Dihua Yu, Catherine Ibarra Drendall 
World J Clin Oncol 6(6):299-311. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.299
Long-term stabilization of metastatic melanoma with sodium dichloroacetate  
Akbar Khan, Doug Andrews, Jill Shainhouse, Anneke C Blackburn 
World J Clin Oncol 8(4):371-377. Published online Aug 10, 2017. doi: 10.5306/wjco.v8.i4.371
Paraneoplastic syndromes associated with lung cancer  
Nobuhiro Kanaji, Naoki Watanabe, Nobuyuki Kita, Shuji Bandoh, Akira Tadokoro, Tomoya Ishii, Hiroaki Dobashi, Takuya Matsunaga 
World J Clin Oncol 5(3):197-223. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.197
Exploiting the homologous recombination DNA repair network for targeted cancer therapy  
Guang Peng, Shiaw-Yih Lin 
World J Clin Oncol 2(2):73-79. Published online Feb 10, 2011. doi: 10.5306/wjco.v2.i2.73
Objective response rate assessment in oncology: Current situation and future expectations  
Nuri Faruk Aykan, Tahsin Özatlı 
World J Clin Oncol 11(2):53-73. Published online Feb 24, 2020. doi: 10.5306/wjco.v11.i2.53
Inorganic phosphate in the development and treatment of cancer: A Janus Bifrons?  
Luigi Sapio, Silvio Naviglio 
World J Clin Oncol 6(6):198-201. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.198
Nephrotoxicity in cancer treatment: An overview  
Maria Luísa Cordeiro Santos, Breno Bittencourt de Brito, Filipe Antônio França da Silva, Anelise Costa dos Santos Botelho, Fabrício Freire de Melo 
World J Clin Oncol 11(4):190-204. Published online Apr 24, 2020. doi: 10.5306/wjco.v11.i4.190
Overview, prevention and management of chemotherapy extravasation  
Firas Y Kreidieh, Hiba A Moukadem, Nagi S El Saghir 
World J Clin Oncol 7(1):87-97. Published online Feb 10, 2016. doi: 10.5306/wjco.v7.i1.87
High intensity focused ultrasound in clinical tumor ablation  
Yu-Feng Zhou 
World J Clin Oncol 2(1):8-27. Published online Jan 10, 2011. doi: 10.5306/wjco.v2.i1.8
Plasma cell leukemia - one in a million: A case report  
Akriti G Jain, Mohammed Faisal-Uddin, Abdul K Khan, Mohammed Wazir, Qi Shen, Manoucher Manoucheri 
World J Clin Oncol 10(3):161-165. Published online Mar 24, 2019. doi: 10.5306/wjco.v10.i3.161
Oncogenic driver mutations in non-small cell lung cancer: Past, present and future   
Mathieu Chevallier, Maxime Borgeaud, Alfredo Addeo, Alex Friedlaender 
World J Clin Oncol 12(4):217-237. Published online Apr 24, 2021. doi: 10.5306/wjco.v12.i4.217
Biomarkers in triple negative breast cancer: A review  
Budhi S Yadav, Priyanka Chanana, Swaty Jhamb 
World J Clin Oncol 6(6):252-263. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.252
Three-dimensional bio-printing: A new frontier in oncology research  
Nitin Charbe, Paul A McCarron, Murtaza M Tambuwala 
World J Clin Oncol 8(1):21-36. Published online Feb 10, 2017. doi: 10.5306/wjco.v8.i1.21
Bethesda System for Reporting Thyroid Cytopathology: A three-year study at a tertiary care referral center in Saudi Arabia  
Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert, Aljuboury Muna, Alkharashi Eyad, Abdullah Al Ghamdi, Khalid Al Hajeri, Mohammed A Thabet, Rim Braham 
World J Clin Oncol 8(2):151-157. Published online Apr 10, 2017. doi: 10.5306/wjco.v8.i2.151
Role of the microbiome in non-gastrointestinal cancers  
Meirav Pevsner-Fischer, Timur Tuganbaev, Mariska Meijer, Sheng-Hong Zhang, Zhi-Rong Zeng, Min-Hu Chen, Eran Elinav 
World J Clin Oncol 7(2):200-213. Published online Apr 10, 2016. doi: 10.5306/wjco.v7.i2.200
Colon cancer and the epidermal growth factor receptor: Current treatment paradigms, the importance of diet, and the role of chemoprevention  
Baldeep Pabla, Marc Bissonnette, Vani J Konda 
World J Clin Oncol 6(5):133-141. Published online Oct 10, 2015. doi: 10.5306/wjco.v6.i5.133
Challenges to the early diagnosis and treatment of breast cancer in developing countries  
Karla Unger-Saldaña 
World J Clin Oncol 5(3):465-477. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.465
Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas  
Eva Wimmer, Stephan Ihrler, Olivier Gires, Sylvia Streit, Wolfgang Issing, Christoph Bergmann 
World J Clin Oncol 10(3):136-148. Published online Mar 24, 2019. doi: 10.5306/wjco.v10.i3.136
Cervical cancer screening in developing countries at a crossroad: Emerging technologies and policy choices  
Rosa Catarino, Patrick Petignat, Gabriel Dongui, Pierre Vassilakos 
World J Clin Oncol 6(6):281-290. Published online Dec 10, 2015. doi: 10.5306/wjco.v6.i6.281
Colorectal liver metastases: Current management and future perspectives  
Jack Martin, Angelica Petrillo, Elizabeth C Smyth, Nadeem Shaida, Samir Khwaja, HK Cheow, Adam Duckworth, Paula Heister, Raaj Praseedom, Asif Jah, Anita Balakrishnan, Simon Harper, Siong Liau, Vasilis Kosmoliaptsis, Emmanuel Huguet 
World J Clin Oncol 11(10):761-808. Published online Oct 24, 2020. doi: 10.5306/wjco.v11.i10.761
Hong Kong female’s breast cancer awareness measure: Cross-sectional survey  
May Pui Shan Yeung, Emily Ying Yang Chan, Samuel Yeung Shan Wong, Benjamin Hon Kei Yip, Polly Suk-Yee Cheung 
World J Clin Oncol 10(2):98-109. Published online Feb 24, 2019. doi: 10.5306/wjco.v10.i2.98
Targeting metabolism in breast cancer: How far we can go?  
Jing-Pei Long, Xiao-Na Li, Feng Zhang 
World J Clin Oncol 7(1):122-130. Published online Feb 10, 2016. doi: 10.5306/wjco.v7.i1.122
Study of recombinant human interleukin-12 for treatment of complications after radiotherapy for tumor patients  
Na Guo, Wen-Qin Wang, Xiao-Jing Gong, Lei Gao, Li-Rong Yang, Wei-Na Yu, Hong-Yu Shen, Ling-Qin Wan, Xi-Feng Jia, Yi-Shan Wang, Yi Zhao 
World J Clin Oncol 8(2):158-167. Published online Apr 10, 2017. doi: 10.5306/wjco.v8.i2.158
Existing anti-angiogenic therapeutic strategies for patients with metastatic colorectal cancer progressing following first-line bevacizumab-based therapy  
Ozkan Kanat, Hulya Ertas 
World J Clin Oncol 10(2):52-61. Published online Feb 24, 2019. doi: 10.5306/wjco.v10.i2.52
Review of anticancer mechanisms of isoquercitin  
Guilherme di Camillo Orfali, Ana Carolina Duarte, Vivien Bonadio, Natalia Peres Martinez, Maria Elisa Melo Branco de Araújo, Fernanda Bruschi Marinho Priviero, Patricia Oliveira Carvalho, Denise Gonçalves Priolli 
World J Clin Oncol 7(2):189-199. Published online Apr 10, 2016. doi: 10.5306/wjco.v7.i2.189
Comparison of the eighth version of the American Joint Committee on Cancer manual to the seventh version for colorectal cancer: A retrospective review of our data  
Guo-Jun Tong, Gui-Yang Zhang, Jian Liu, Zhao-Zheng Zheng, Yan Chen, Ping-Ping Niu, Xu-Ting Xu 
World J Clin Oncol 9(7):148-161. Published online Nov 10, 2018. doi: 10.5306/wjco.v9.i7.148
Cell-free DNA integrity for the monitoring of breast cancer: Future perspectives?  
Navid Sobhani, Daniele Generali, Fabrizio Zanconati, Marina Bortul, Bruna Scaggiante 
World J Clin Oncol 9(2):26-32. Published online Apr 10, 2018. doi: 10.5306/wjco.v9.i2.26
Imaging of gastroenteropancreatic neuroendocrine tumors  
Eik Hock Tan, Cher Heng Tan 
World J Clin Oncol 2(1):28-43. Published online Jan 10, 2011. doi: 10.5306/wjco.v2.i1.28
Serendipity in anticancer drug discovery  
Emily Hargrave-Thomas, Bo Yu, Jóhannes Reynisson 
World J Clin Oncol 3(1):1-6. Published online Jan 10, 2012. doi: 10.5306/wjco.v3.i1.1
Palliative surgery for Krukenberg tumors – 12-year experience and review of the literature  
Isaac Seow-En, Gwen Hwarng, Grace Hwei Ching Tan, Leonard Ming Li Ho, Melissa Ching Ching Teo 
World J Clin Oncol 9(1):13-19. Published online Feb 10, 2018. doi: 10.5306/wjco.v9.i1.13
Therapeutic management options for stage III non-small cell lung cancer  
Stephanie M Yoon, Talha Shaikh, Mark Hallman 
World J Clin Oncol 8(1):1-20. Published online Feb 10, 2017. doi: 10.5306/wjco.v8.i1.1
Evolving role of Sorafenib in the management of hepatocellular carcinoma  
Ioannis A Ziogas, Georgios Tsoulfas 
World J Clin Oncol 8(3):203-213. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.203
Sentinel lymph node mapping of a breast cancer of the vulva: Case report and literature review  
James Cripe, Ramez Eskander, Krishnansu Tewari 
World J Clin Oncol 6(2):16-21. Published online Apr 10, 2015. doi: 10.5306/wjco.v6.i2.16
Health Council of the Netherlands and evaluation of the fifth generation, 5G, for wireless communication and cancer risks  
Lennart Hardell 
World J Clin Oncol 12(6):393-403. Published online Jun 24, 2021. doi: 10.5306/wjco.v12.i6.393
Clinical application of DNA ploidy to cervical cancer screening: A review  
David Garner 
World J Clin Oncol 5(5):931-965. Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.931
Immunotherapy in pancreatic cancer: Unleash its potential through novel combinations  
Songchuan Guo, Merly Contratto, George Miller, Lawrence Leichman, Jennifer Wu 
World J Clin Oncol 8(3):230-240. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.230
Surgical strategy for bile duct cancer: Advances and current limitations  
Nobuhisa Akamatsu, Yasuhiko Sugawara, Daijo Hashimoto 
World J Clin Oncol 2(2):94-107. Published online Feb 10, 2011. doi: 10.5306/wjco.v2.i2.94
Immediate nipple-areola-sparing mastectomy reconstruction: An update on oncological and reconstruction techniques  
Alexandre Mendonça Munhoz, Eduardo Montag, José Roberto Filassi, Rolf Gemperli 
World J Clin Oncol 5(3):478-494. Published online Aug 10, 2014. doi: 10.5306/wjco.v5.i3.478
Polyubiquitination inhibition of estrogen receptor alpha and its implications in breast cancer  
Angeles C Tecalco-Cruz, Josué O Ramírez-Jarquín 
World J Clin Oncol 9(4):60-70. Published online Aug 13, 2018. doi: 10.5306/wjco.v9.i4.60
Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer  
Cynthia I Tchio Mantho, Adriana Harbuzariu, Ruben R Gonzalez-Perez 
World J Clin Oncol 8(3):178-189. Published online Jun 10, 2017. doi: 10.5306/wjco.v8.i3.178
Nanoparticle-linked antagonist for leptin signaling inhibition in breast cancer  
Tia Harmon, Adriana Harbuzariu, Viola Lanier, Crystal C Lipsey, Ward Kirlin, Lily Yang, Ruben R Gonzalez-Perez 
World J Clin Oncol 8(1):54-66. Published online Feb 10, 2017. doi: 10.5306/wjco.v8.i1.54
Cyclooxygenase-2 and the inflammogenesis of breast cancer  
Randall E Harris, Bruce C Casto, Zachary M Harris 
World J Clin Oncol 5(4):677-692. Published online Oct 10, 2014. doi: 10.5306/wjco.v5.i4.677