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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Which is the best choice for gastroesophageal disorders: Melatonin or proton pump inhibitors?  
Joanna Dulce Favacho de Oliveira Torres, Ricardo de Souza Pereira 
World J Gastrointest Pharmacol Ther 1(5):102-106. Published online Oct 6, 2010. doi: 10.4292/wjgpt.v1.i5.102
2
Psychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicity  
Diogo Telles-Correia, António Barbosa, Helena Cortez-Pinto, Carlos Campos, Nuno B F Rocha, Sérgio Machado 
World J Gastrointest Pharmacol Ther 8(1):26-38. Published online Feb 6, 2017. doi: 10.4292/wjgpt.v8.i1.26
3
Logical hypothesis: Low FODMAP diet to prevent diverticulitis  
Yoshiharu Uno, Jennifer C van Velkinburgh 
World J Gastrointest Pharmacol Ther 7(4):503-512. Published online Nov 6, 2016. doi: 10.4292/wjgpt.v7.i4.503
4
Phage therapy: An alternative to antibiotics in the age of multi-drug resistance  
Derek M Lin, Britt Koskella, Henry C Lin 
World J Gastrointest Pharmacol Ther 8(3):162-173. Published online Aug 6, 2017. doi: 10.4292/wjgpt.v8.i3.162
5
Review of efficacy and safety of laxatives use in geriatrics  
Manhal Izzy, Anju Malieckal, Erin Little, Sury Anand 
World J Gastrointest Pharmacol Ther 7(2):334-342. Published online May 6, 2016. doi: 10.4292/wjgpt.v7.i2.334
6
Pathogenic mechanisms of pancreatitis  
Murli Manohar, Alok Kumar Verma, Sathisha Upparahalli Venkateshaiah, Nathan L Sanders, Anil Mishra 
World J Gastrointest Pharmacol Ther 8(1):10-25. Published online Feb 6, 2017. doi: 10.4292/wjgpt.v8.i1.10
7
Therapy of gallstone disease: What it was, what it is, what it will be  
Piero Portincasa, Agostino Di Ciaula, Leonilde Bonfrate, David QH Wang 
World J Gastrointest Pharmacol Ther 3(2):7-20. Published online Apr 6, 2012. doi: 10.4292/wjgpt.v3.i2.7
8
Management of esophageal caustic injury  
Mark Anthony A De Lusong, Aeden Bernice G Timbol, Danny Joseph S Tuazon 
World J Gastrointest Pharmacol Ther 8(2):90-98. Published online May 6, 2017. doi: 10.4292/wjgpt.v8.i2.90
9
Eosinophilic gastroenteritis: Approach to diagnosis and management  
Antoine Abou Rached, Weam El Hajj 
World J Gastrointest Pharmacol Ther 7(4):513-523. Published online Nov 6, 2016. doi: 10.4292/wjgpt.v7.i4.513
10
Influence of environmental factors in the development of inflammatory bowel diseases  
Evangelia Legaki, Maria Gazouli 
World J Gastrointest Pharmacol Ther 7(1):112-125. Published online Feb 6, 2016. doi: 10.4292/wjgpt.v7.i1.112
11
Identifying the best therapy for chronic anal fissure  
Mariusz H Madalinski 
World J Gastrointest Pharmacol Ther 2(2):9-16. Published online Apr 6, 2011. doi: 10.4292/wjgpt.v2.i2.9
12
Interferon-free treatments in patients with hepatitis C genotype 1-4 infections in a real-world setting  
Huascar Ramos, Pedro Linares, Ester Badia, Isabel Martín, Judith Gómez, Carolina Almohalla, Francisco Jorquera, Sara Calvo, Isidro García, Pilar Conde, Begoña Álvarez, Guillermo Karpman, Sara Lorenzo, Visitación Gozalo, Mónica Vásquez, Diana Joao, Marina de Benito, Lourdes Ruiz, Felipe Jiménez, Federico Sáez-Royuela, Asociación Castellano y Leonesa de Hepatología (ACyLHE) 
World J Gastrointest Pharmacol Ther 8(2):137-146. Published online May 6, 2017. doi: 10.4292/wjgpt.v8.i2.137
13
Update on the management of gastrointestinal varices  
Umesha Boregowda, Chandraprakash Umapathy, Nasir Halim, Madhav Desai, Arpitha Nanjappa, Subramanyeswara Arekapudi, Thimmaiah Theethira, Helen Wong, Marina Roytman, Shreyas Saligram 
World J Gastrointest Pharmacol Ther 10(1):1-21. Published online Jan 21, 2019. doi: 10.4292/wjgpt.v10.i1.1
14
Mesalazine preparations for the treatment of ulcerative colitis: Are all created equal?  
Bei Ye, Daniel R van Langenberg 
World J Gastrointest Pharmacol Ther 6(4):137-144. Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.137
15
Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management  
Pegah Hosseini-Carroll, Monica Mutyala, Abhishek Seth, Shaheen Nageeb, Demiana Soliman, Moheb Boktor, Ankur Sheth, Jonathon Chapman, James Morris, Paul Jordan, Kenneth Manas, Felix Becker, Jonathan Steven Alexander 
World J Gastrointest Pharmacol Ther 6(4):156-171. Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.156
16
Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: Results from a randomized double blind placebo controlled trial  
Saurabh Kedia, Vikram Bhatia, Sandeep Thareja, Sushil Garg, Venigalla Pratap Mouli, Sawan Bopanna, Veena Tiwari, Govind Makharia, Vineet Ahuja 
World J Gastrointest Pharmacol Ther 8(2):147-154. Published online May 6, 2017. doi: 10.4292/wjgpt.v8.i2.147
17
Diagnosis and therapy of non-variceal upper gastrointestinal bleeding  
Erwin Biecker 
World J Gastrointest Pharmacol Ther 6(4):172-182. Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.172
18
Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis  
Kunwar Shailubhai, Vaseem Palejwala, Krishna Priya Arjunan, Sayali Saykhedkar, Bradley Nefsky, John A Foss, Stephen Comiskey, Gary S Jacob, Scott E Plevy 
World J Gastrointest Pharmacol Ther 6(4):213-222. Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.213
19
Update on clinical and research application of fecal biomarkers for gastrointestinal diseases  
Imran Siddiqui, Hafsa Majid, Shahab Abid 
World J Gastrointest Pharmacol Ther 8(1):39-46. Published online Feb 6, 2017. doi: 10.4292/wjgpt.v8.i1.39
20
Transoral incisionless fundoplication for gastro-esophageal reflux disease: Techniques and outcomes  
Pier Alberto Testoni, Giorgia Mazzoleni, Sabrina Gloria Giulia Testoni 
World J Gastrointest Pharmacol Ther 7(2):179-189. Published online May 6, 2016. doi: 10.4292/wjgpt.v7.i2.179
21
Management of pain in chronic pancreatitis with emphasis on exogenous pancreatic enzymes  
Paul M Hobbs, William G Johnson, David Y Graham 
World J Gastrointest Pharmacol Ther 7(3):370-386. Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.370
22
Clinical relevance of clopidogrel-proton pump inhibitors interaction  
Stella D Bouziana, Konstantinos Tziomalos 
World J Gastrointest Pharmacol Ther 6(2):17-21. Published online May 6, 2015. doi: 10.4292/wjgpt.v6.i2.17
23
Thiol/disulphide homeostasis in celiac disease  
Mustafa Kaplan, Ihsan Ates, Mahmut Yuksel, Yasemin Ozderin Ozin, Murat Alisik, Ozcan Erel, Ertugrul Kayacetin 
World J Gastrointest Pharmacol Ther 8(2):120-126. Published online May 6, 2017. doi: 10.4292/wjgpt.v8.i2.120
24
Eosinophilic esophagitis: New insights in pathogenesis and therapy  
Michele Pier Luca Guarino, Michele Cicala, Jose Behar 
World J Gastrointest Pharmacol Ther 7(1):66-77. Published online Feb 6, 2016. doi: 10.4292/wjgpt.v7.i1.66
25
Antibiotic treatment for Helicobacter pylori: Is the end coming?  
Su Young Kim, Duck Joo Choi, Jun-Won Chung 
World J Gastrointest Pharmacol Ther 6(4):183-198. Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.183
26
Non-pharmacological treatment of Helicobacter pylori  
Haim Shmuely, Noam Domniz, Jacob Yahav 
World J Gastrointest Pharmacol Ther 7(2):171-178. Published online May 6, 2016. doi: 10.4292/wjgpt.v7.i2.171
27
Usefulness of vonoprazan, a potassium ion-competitive acid blocker, for primary eradication of Helicobacter pylori  
Shinya Yamada, Takumi Kawakami, Yoshikazu Nakatsugawa, Takahiro Suzuki, Hideki Fujii, Naoya Tomatsuri, Hideki Nakamura, Hideki Sato, Yusuke Okuyama, Hiroyuki Kimura, Norimasa Yoshida 
World J Gastrointest Pharmacol Ther 7(4):550-555. Published online Nov 6, 2016. doi: 10.4292/wjgpt.v7.i4.550
28
Barrett’s esophagus in 2016: From pathophysiology to treatment  
Irene Martinucci, Nicola de Bortoli, Salvatore Russo, Lorenzo Bertani, Manuele Furnari, Anna Mokrowiecka, Ewa Malecka-Panas, Vincenzo Savarino, Edoardo Savarino, Santino Marchi 
World J Gastrointest Pharmacol Ther 7(2):190-206. Published online May 6, 2016. doi: 10.4292/wjgpt.v7.i2.190
29
Aspirin, cyclooxygenase inhibition and colorectal cancer  
Carlos Sostres, Carla Jerusalen Gargallo, Angel Lanas 
World J Gastrointest Pharmacol Ther 5(1):40-49. Published online Feb 6, 2014. doi: 10.4292/wjgpt.v5.i1.40
30
Crohn’s disease of esophagus, stomach and duodenum  
Andréa Maia Pimentel, Raquel Rocha, Genoile Oliveira Santana 
World J Gastrointest Pharmacol Ther 10(2):35-49. Published online Mar 7, 2019. doi: 10.4292/wjgpt.v10.i2.35
31
Family history and disease outcomes in patients with Crohn’s disease: A comparison between China and the United States  
Pei-Qi Wang, Jun Hu, Elie S Al Kazzi, Eboselume Akhuemonkhan, Min Zhi, Xiang Gao, Raquel Holand de Paula Pessoa, Sami Ghazaleh, Tuhina Cornelius, Suhel Abbas Sabunwala, Shadi Ghadermarzi, Kartikeya Tripathi, Mark Lazarev, Pin-Jin Hu, Susan Hutfless 
World J Gastrointest Pharmacol Ther 7(4):556-563. Published online Nov 6, 2016. doi: 10.4292/wjgpt.v7.i4.556
32
Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a-/- mice  
Kelley MK Haarberg, Meghan J Wymore Brand, Anne-Marie C Overstreet, Catherine C Hauck, Patricia A Murphy, Jesse M Hostetter, Amanda E Ramer-Tait, Michael J Wannemuehler 
World J Gastrointest Pharmacol Ther 6(4):223-237. Published online Nov 6, 2015. doi: 10.4292/wjgpt.v6.i4.223
33
Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature  
Dominik D Alexander, Lauren C Bylsma, Laura Elkayam, Douglas L Nguyen 
World J Gastrointest Pharmacol Ther 7(2):306-319. Published online May 6, 2016. doi: 10.4292/wjgpt.v7.i2.306
34
Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases  
Imene Soufli, Ryma Toumi, Hayet Rafa, Chafia Touil-Boukoffa 
World J Gastrointest Pharmacol Ther 7(3):353-360. Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.353
35
Predictive factors for a severe clinical course in ulcerative colitis: Results from population-based studies  
Magnus Hofrenning Wanderås, Bjørn A Moum, Marte Lie Høivik, Øistein Hovde 
World J Gastrointest Pharmacol Ther 7(2):235-241. Published online May 6, 2016. doi: 10.4292/wjgpt.v7.i2.235
36
Pharmacological- and non-pharmacological therapeutic approaches in inflammatory bowel disease in adults  
Gerda C Leitner, Harald Vogelsang 
World J Gastrointest Pharmacol Ther 7(1):5-20. Published online Feb 6, 2016. doi: 10.4292/wjgpt.v7.i1.5
37
Evaluation of gastrointestinal bleeding: Update of current radiologic strategies  
Parth J Parekh, Ross C Buerlein, Rouzbeh Shams, Harlan Vingan, David A Johnson 
World J Gastrointest Pharmacol Ther 5(4):200-208. Published online Nov 6, 2014. doi: 10.4292/wjgpt.v5.i4.200
38
Helicobacter pylori and its reservoirs: A correlation with the gastric infection  
Spencer Luiz Marques Payão, Lucas Trevizani Rasmussen 
World J Gastrointest Pharmacol Ther 7(1):126-132. Published online Feb 6, 2016. doi: 10.4292/wjgpt.v7.i1.126
39
Combination therapy for inflammatory bowel disease  
Keith S Sultan, Joshua C Berkowitz, Sundas Khan 
World J Gastrointest Pharmacol Ther 8(2):103-113. Published online May 6, 2017. doi: 10.4292/wjgpt.v8.i2.103
40
Hepatitis C virus: A time for decisions. Who should be treated and when?  
Bashar M Attar, David H Van Thiel 
World J Gastrointest Pharmacol Ther 7(1):33-40. Published online Feb 6, 2016. doi: 10.4292/wjgpt.v7.i1.33
41
Clinical and economic impact of infliximab one-hour infusion protocol in patients with inflammatory bowel diseases: A multicenter study  
Anna Viola, Giuseppe Costantino, Antonino Carlo Privitera, Fabrizio Bossa, Angelo Lauria, Laurino Grossi, Maria Beatrice Principi, Nicola Della Valle, Maria Cappello 
World J Gastrointest Pharmacol Ther 8(2):131-136. Published online May 6, 2017. doi: 10.4292/wjgpt.v8.i2.131
42
Correlation of rapid point-of-care vs send-out fecal calprotectin monitoring in pediatric inflammatory bowel disease  
Alexis Rodriguez, Lauren Yokomizo, Megan Christofferson, Danielle Barnes, Nasim Khavari, K T Park 
World J Gastrointest Pharmacol Ther 8(2):127-130. Published online May 6, 2017. doi: 10.4292/wjgpt.v8.i2.127
43
Bilirubin in coronary artery disease: Cytotoxic or protective?  
Nancy Gupta, Tavankit Singh, Rahul Chaudhary, Sushil K Garg, Gurprataap Singh Sandhu, Varun Mittal, Rahul Gupta, Roxana Bodin, Sachin Sule 
World J Gastrointest Pharmacol Ther 7(4):469-476. Published online Nov 6, 2016. doi: 10.4292/wjgpt.v7.i4.469
44
Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice  
Wen-Chi L Chang, Shet Masih, Anusha Thadi, Viren Patwa, Apoorva Joshi, Harry S Cooper, Vaseem A Palejwala, Margie L Clapper, Kunwar Shailubhai 
World J Gastrointest Pharmacol Ther 8(1):47-59. Published online Feb 6, 2017. doi: 10.4292/wjgpt.v8.i1.47
45
Lymphocyte-to-monocyte ratio can predict mortality in pancreatic adenocarcinoma  
Gurshawn Singh, Ammar Nassri, David Kim, Hong Zhu, Zeeshan Ramzan 
World J Gastrointest Pharmacol Ther 8(1):60-66. Published online Feb 6, 2017. doi: 10.4292/wjgpt.v8.i1.60
46
Recent discoveries and emerging therapeutics in eosinophilic esophagitis  
Aakash Goyal, Edaire Cheng 
World J Gastrointest Pharmacol Ther 7(1):21-32. Published online Feb 6, 2016. doi: 10.4292/wjgpt.v7.i1.21
47
Response of irritable bowel syndrome with constipation patients administered a combined quebracho/conker tree/M. balsamea Willd extract  
Kenneth Brown, Brandi Scott-Hoy, Linda W Jennings 
World J Gastrointest Pharmacol Ther 7(3):463-468. Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.463
48
Tryptophan: A gut microbiota-derived metabolites regulating inflammation  
Lucie Etienne-Mesmin, Benoit Chassaing, Andrew T Gewirtz 
World J Gastrointest Pharmacol Ther 8(1):7-9. Published online Feb 6, 2017. doi: 10.4292/wjgpt.v8.i1.7
49
Update on management of Barrett's esophagus  
Fernando Macías-García, J Enrique Domínguez-Muñoz 
World J Gastrointest Pharmacol Ther 7(2):227-234. Published online May 6, 2016. doi: 10.4292/wjgpt.v7.i2.227
50
Dendritic cell-based vaccine for pancreatic cancer in Japan  
Masato Okamoto, Masanori Kobayashi, Yoshikazu Yonemitsu, Shigeo Koido, Sadamu Homma 
World J Gastrointest Pharmacol Ther 7(1):133-138. Published online Feb 6, 2016. doi: 10.4292/wjgpt.v7.i1.133