World Journal of Gastrointestinal Pharmacology and Therapeutics

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Welcome to the World Journal of Gastrointestinal Pharmacology and Therapeutics

Antimicrobial peptide development pipeline: From computational discovery through molecular optimisation, formulation engineering, and clinical translation.

Changes in serum bile acid levels in patients after odevixibat.

Enteric nervous system targets for prokinetic therapy.

Mechanism of action of various Janus kinase inhibitors and their downstream effects.

Immunomodulatory effects of stereotactic body radiation therapy.

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Letter to the Editor: Less can be more, rethinking colonic biopsy strategies for microscopic colitis in the era of green endoscopy

Featured Articles More >>

Letter to the Editor: Less can be more, rethinking colonic b... 2026-09-01
Beyond class switching in multi-refractory inflammatory bowe... 2026-09-01
Hemodynamic safety of remimazolam vs propofol in elderly pat... 2026-09-01
Beyond the Gut microbe: rethinking infection, microbiome har... 2026-09-01
Serial Bogota bag tightening: A pragmatic advance in open ab... 2026-09-01

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World Journal of Gastrointestinal Pharmacology and Therapeutics is an international, peer-reviewed, open-access academic journal dedicated to publishing original, high-quality research findings in the field of gastrointestinal pharmacology and therapeutics, including clinical, translational, and basic studies, as well as research involving artificial intelligence. The journal focuses on, but is not limited to, the following areas: Acid-related disorders, gastrointestinal disease, hepatic and biliary disorders, pancreatic disorders, pharmacokinetics, clinical pharmacology, therapeutics. Types of articles published by the journal include clinical study, basic study, case report, editorial, review, minireview, systematic review, meta-analysis, guidelines, and correspondence. All submissions undergo a rigorous and transparent peer-review process by at least two independent reviewers. Manuscripts are evaluated based on scientific rigor, originality, clinical relevance, and reproducibility, with particular attention to methodological robustness and data integrity. Constructive and timely feedback is provided to ensure the highest standards of scholarly communication. The journal adheres to the highest standards of publication ethics and editorial integrity, in accordance with the guidelines of the Committee on Publication Ethics, the International Committee of Medical Journal Editors, and the World Association of Medical Editors. To advance scientific discovery, promote evidence-based clinical practice, and foster innovation in gastrointestinal pharmacology and therapeutics, ultimately improving global health outcomes. We invite researchers, clinicians, and multidisciplinary experts worldwide to submit high-quality manuscripts and contribute to shaping the future of gastrointestinal pharmacological and therapeutic science. Submit an Article >>

2026 Published Issues

3 2 1

Editors-in-Chief

Emanuele Sinagra, PhD, (E-mail: emanuelesinagra83@googlemail.com) Gastroenterology and Endoscopy Unit, Fondazione Istituto Giuseppe Giglio, Cefalù 90015, Italy

Indexing/Abstracting

The WJGPT is now abstracted and indexed in PubMed, PubMed Central, Reference Citation Analysis, China Science and Technology Journal Database, and Superstar Journals Database.

Journal Metrics

There is currently no impact factor.

ISSN

2150-5349 (online)

Latest Manuscript Statistics

Received (512), Duration of Peer Review (24 days/Mean), Days from Submission to First Decision (39 days/Mean), Second Decision Time (35 days/Mean), Accepted (60.9%/Mean), Production Time (53 days/Mean), Time to Publication (181 days/Mean), and Rejected (25.2%/Mean).

Current Issue

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Contents Volume 17 Issue 3 September 5, 2026

Editorial

Serial Bogota bag tightening: A pragmatic advance in open abdomen management for resource-limited settings

Gemechu Dereje Feyissa

World J Gastrointest Pharmacol Ther 17(3):120768. Published online Sep 5, 2026. doi: 10.4292/wjgpt.120768

Opinion Review

Beyond the gut microbe: Rethinking infection, microbiome harmony, and the one-health continuum

Sumit Rai, Prasan Kumar Panda

World J Gastrointest Pharmacol Ther 17(3):119031. Published online Sep 5, 2026. doi: 10.4292/wjgpt.119031

Minireviews

Nor-ursodeoxycholic acid in hepatobiliary diseases: A narrative review

Sayan Malakar, Neha Sood, Suprabhat Giri, Arghya Samanta

World J Gastrointest Pharmacol Ther 17(3):120122. Published online Sep 5, 2026. doi: 10.4292/wjgpt.120122

Status of robotic and manual devices for advanced colonoscopy: Trends and applications of robotics in colonoscopy

Saleh A Busbait, Koby Herman, Shayan Assaie-Ardakany, Jasneet S Bhullar

World J Gastrointest Pharmacol Ther 17(3):121231. Published online Sep 5, 2026. doi: 10.4292/wjgpt.121231

Emerging antimicrobial peptides in gastrointestinal disorders: Dual role in immunity and therapy

Keerthika Selvaraj, Chandrashekaran Girish

World J Gastrointest Pharmacol Ther 17(3):122448. Published online Sep 5, 2026. doi: 10.4292/wjgpt.122448

Systematic Reviews

Survival in unresectable hepatocellular carcinoma: Comparison of four treatments based on patients reconstructed from Kaplan–Meier curves of randomized trials

Vera Damuzzo, Stefano Vecchia, Lorenzo Gasperoni, Luna Del Bono, Andrea Ossato, Elena Orlandi, Andrea Messori

World J Gastrointest Pharmacol Ther 17(3):120377. Published online Sep 5, 2026. doi: 10.4292/wjgpt.120377

Meta-Analysis

Hemodynamic safety of remimazolam vs propofol in elderly patients

Nawal Tahir, Adil Khan, Sidra Faryal, Muhammad Faizan, Ayesha Irshad, Umer Iqbal, Muaaz Wasay, Syed A Arsal, Aashish Kumar, Inibehe I Okon, Shafin Bin Amin

World J Gastrointest Pharmacol Ther 17(3):120256. Published online Sep 5, 2026. doi: 10.4292/wjgpt.120256

Case Report

Beyond class switching in multi-refractory inflammatory bowel disease: Nine case reports and review of literature

Jonathan Soldera, Maria Antonia Selbach Pertile, Leticia Nodari Carobin, Daniel Jun Funatsu Brambilla, Eduardo Brambilla

World J Gastrointest Pharmacol Ther 17(3):120771. Published online Sep 5, 2026. doi: 10.4292/wjgpt.120771

Correspondence

Letter to the Editor: Less can be more, rethinking colonic biopsy strategies for microscopic colitis in the era of green endoscopy

Himanshu Agrawal, Nikhil Gupta

World J Gastrointest Pharmacol Ther 17(3):119904. Published online Sep 5, 2026. doi: 10.4292/wjgpt.119904

Letter to the Editor: Can upadacitinib dose escalation redefine treatment strategies in refractory inflammatory bowel disease?

Himanshu Agrawal, Nikhil Gupta

World J Gastrointest Pharmacol Ther 17(3):122912. Published online Sep 5, 2026. doi: 10.4292/wjgpt.122912

Letter to the Editor: From association to mechanism - advancing the understanding of small intestinal bacterial overgrowth in acute pancreatitis

Shree V Dhotre, Pradnya S Dhotre, Basavraj S Nagoba

World J Gastrointest Pharmacol Ther 17(3):123931. Published online Sep 5, 2026. doi: 10.4292/wjgpt.123931