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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Aug 6, 2016; 7(3): 463-468
Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.463
Published online Aug 6, 2016. doi: 10.4292/wjgpt.v7.i3.463
Response of irritable bowel syndrome with constipation patients administered a combined quebracho/conker tree/M. balsamea Willd extract
Kenneth Brown, Brandi Scott-Hoy, KBS Research LLC, Dallas, TX 75248, United States
Linda W Jennings, Annette C and Harold C Simmons Transplant Institute, Baylor Scott and White Health, Dallas, TX 75246, United States
Author contributions: Brown K and Scott-Hoy B contributed equally to this work; Brown K and Scott-Hoy B substantially contributed to conception, design and interpretation of the case series data, critical revisions of the manuscript, and final approval of the manuscript; Jennings LW contributed substantially to the analysis and interpretation of the case series data, critical revision and important intellectual concepts in the manuscript and final approval of the manuscript.
Institutional review board statement: The study is exempt from IRB review and oversight pursuant to the terms of the United States Department of Health and Human Service’s Policy for Protection of Human Research Subjects at 45 CFR and 46.101(b) since the data already exists in patient medical charts and this data was accumulated retrospectively. There was no experimentation on patients. The botanical extract was recommended to patients who chose to take the formulation.
Informed consent statement: All patients gave their verbal consent for publication of their anonymous medical chart data.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Brandi Scott-Hoy, MD, KBS Research LLC, 15660 N Dallas Parkway, Suite 700, Dallas, TX 75248, United States. brandi@kbsresearch.com
Telephone: +1-214-9843724
Received: February 23, 2016
Peer-review started: February 23, 2016
First decision: March 30, 2016
Revised: May 8, 2016
Accepted: June 14, 2016
Article in press: June 16, 2016
Published online: August 6, 2016
Peer-review started: February 23, 2016
First decision: March 30, 2016
Revised: May 8, 2016
Accepted: June 14, 2016
Article in press: June 16, 2016
Published online: August 6, 2016
Core Tip
Core tip: Irritable bowel syndrome with constipation (IBS-C) is a diagnosis by exclusion which is defined by abdominal pain accompanied by reduced stool frequency and painful, hard bowel movements. Gas and bloating may also be present in many patients with this condition suggesting a role in fermentation of food producing gas by bacteria in the gut. Safe tannin byproducts from wineries used in cows to reduce gas that can impair milk and meat production are combined with saponins, shown to be antibacterial and promote intestinal motility, and peppermint oil for abdominal pain in this combination extract (Atrantil™) to manage key IBS-C symptoms.