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Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. Feb 6, 2017; 8(1): 7-9
Published online Feb 6, 2017. doi: 10.4292/wjgpt.v8.i1.7
Tryptophan: A gut microbiota-derived metabolites regulating inflammation
Lucie Etienne-Mesmin, Benoit Chassaing, Andrew T Gewirtz
Lucie Etienne-Mesmin, Benoit Chassaing, Andrew T Gewirtz, Center for Inflammation, Immunity, and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, United States
Author contributions: Etienne-Mesmin L wrote the manuscript; Chassaing B and Gewirtz AT critically revised the manuscript.
Supported by National Institutes of Health (NIH), Nos. DK099071 and DK083890; the Career Development Award from the Crohn’s and Colitis Foundation of America (CCFA).
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lucie Etienne-Mesmin, PhD, Center for Inflammation, Immunity, and Infection, Institute for Biomedical Sciences, Georgia State University, 100 Piedmont Ave SE, Atlanta, GA 30303, United States. letiennemesmin@gsu.edu
Telephone: +1-404-4133589 Fax: +1-404-4133580
Received: August 12, 2016
Peer-review started: August 12, 2016
First decision: September 16, 2016
Revised: September 22, 2016
Accepted: October 22, 2016
Article in press: October 24, 2016
Published online: February 6, 2017
Core Tip

Core tip: A noteworthy article published in Nature Medicine by Lamas and colleagues highlights the role of tryptophan, a microbiota-derived metabolite, in reducing inflammation in the gut. This commentary puts in perspective the main results from this study.