Abstract (1007) | Core Tip (836) | Full Article (HTML) (4701) | Figures (1-2) (692) | Tables (1-3) (424) | Full Article (PDF)-3008K (404) | Audio-232K (11) | Peer-Review Report-224K (158) | Answering Reviewers-4K (154) | Received: 01/26/2021 | Revised: 06/15/2021 | Accepted: 08/23/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (5) | Total Visits (11890) | Similar Articles (0) | Timeline of Article Publication (12) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (1167) | Core Tip (779) | Full Article (HTML) (6015) | Figures (1-2) (447) | Tables (1-1) (465) | Full Article (PDF)-1931K (450) | Audio-608K (23) | Peer-Review Report-291K (140) | Answering Reviewers-164K (145) | Received: 02/28/2021 | Revised: 05/04/2021 | Accepted: 08/10/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (32) | Total Visits (12808) | Similar Articles (69) | Timeline of Article Publication (7) | Authors Evaluation (1) | Article Quality Tracking (0) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (1183) | Core Tip (696) | Full Article (HTML) (2705) | Figures (1-1) (504) | Full Article (PDF)-1319K (344) | Audio-2991K (17) | Peer-Review Report-208K (166) | Answering Reviewers-104K (131) | Received: 02/03/2021 | Revised: 04/30/2021 | Accepted: 08/27/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (7654) | Similar Articles (0) | Timeline of Article Publication (2) | Authors Evaluation (3) | Article Quality Tracking (0) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (1201) | Core Tip (822) | Full Article (HTML) (5617) | Figures (1-2) (591) | Full Article (PDF)-2593K (574) | Audio-978K (8) | Peer-Review Report-219K (198) | Answering Reviewers-150K (210) | Received: 03/06/2021 | Revised: 04/12/2021 | Accepted: 07/29/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (39) | Total Visits (12285) | Similar Articles (829) | Timeline of Article Publication (2) | Authors Evaluation (3) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (2) | Open

Abstract (845) | Core Tip (631) | Article Highlights (797) | Full Article (HTML) (2257) | Figures (1-2) (295) | Full Article (PDF)-1896K (277) | Audio-942K (4) | Peer-Review Report-151K (131) | Answering Reviewers-76K (125) | Received: 06/10/2021 | Revised: 07/10/2021 | Accepted: 08/16/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (8) | Total Visits (8407) | Similar Articles (0) | Timeline of Article Publication (0) | Authors Evaluation (3) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (822) | Core Tip (649) | Article Highlights (694) | Full Article (HTML) (3071) | Tables (1-7) (381) | Full Article (PDF)-1035K (341) | Audio-524K (7) | Peer-Review Report-221K (127) | Answering Reviewers-106K (161) | Received: 05/27/2021 | Revised: 07/04/2021 | Accepted: 08/05/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (5) | Total Visits (8663) | Similar Articles (0) | Timeline of Article Publication (5) | Authors Evaluation (1) | Article Quality Tracking (0) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (1266) | Core Tip (1189) | Article Highlights (865) | Full Article (HTML) (2201) | Tables (1-6) (405) | Full Article (PDF)-1027K (241) | Audio-732K (4) | Peer-Review Report-223K (190) | Answering Reviewers-105K (117) | Received: 05/27/2021 | Revised: 07/02/2021 | Accepted: 08/05/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (5) | Total Visits (9538) | Similar Articles (0) | Timeline of Article Publication (3) | Authors Evaluation (1) | Article Quality Tracking (0) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (862) | Core Tip (1030) | Article Highlights (796) | Full Article (HTML) (2005) | Tables (1-5) (324) | Full Article (PDF)-1023K (239) | Audio-677K (6) | Peer-Review Report-174K (150) | Answering Reviewers-102K (134) | Received: 06/02/2021 | Revised: 07/05/2021 | Accepted: 08/05/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (8688) | Similar Articles (24) | Timeline of Article Publication (5) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (911) | Core Tip (734) | Article Highlights (812) | Full Article (HTML) (2388) | Tables (1-2) (396) | Full Article (PDF)-1083K (349) | Audio-565K (5) | Peer-Review Report-165K (137) | Answering Reviewers-136K (159) | Received: 06/12/2021 | Revised: 07/19/2021 | Accepted: 08/18/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (4) | Total Visits (8598) | Similar Articles (706) | Timeline of Article Publication (1) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (706) | Core Tip (754) | Article Highlights (790) | Full Article (HTML) (2692) | Figures (1-9) (397) | Tables (1-3) (373) | Full Article (PDF)-4235K (348) | Audio-618K (5) | Peer-Review Report-236K (135) | Answering Reviewers-204K (166) | Received: 04/13/2021 | Revised: 06/08/2021 | Accepted: 08/16/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (11135) | Similar Articles (702) | Timeline of Article Publication (2) | Authors Evaluation (4) | Article Quality Tracking (0) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (803) | Core Tip (696) | Article Highlights (1160) | Full Article (HTML) (1924) | Figures (1-2) (369) | Tables (1-1) (398) | Full Article (PDF)-1365K (250) | Audio-560K (3) | Peer-Review Report-127K (136) | Answering Reviewers-137K (132) | Received: 06/22/2021 | Revised: 07/22/2021 | Accepted: 08/30/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (5) | Total Visits (9293) | Similar Articles (10) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (1150) | Core Tip (662) | Article Highlights (1009) | Full Article (HTML) (2205) | Figures (1-1) (717) | Tables (1-4) (359) | Full Article (PDF)-1162K (255) | Audio-1274K (10) | Peer-Review Report-187K (162) | Answering Reviewers-688K (129) | Received: 03/22/2021 | Revised: 05/12/2021 | Accepted: 08/16/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (9708) | Similar Articles (46) | Timeline of Article Publication (2) | Authors Evaluation (2) | Article Quality Tracking (0) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (675) | Core Tip (1079) | Article Highlights (793) | Full Article (HTML) (2244) | Figures (1-5) (400) | Tables (1-2) (394) | Full Article (PDF)-2182K (314) | Audio-847K (5) | Peer-Review Report-197K (130) | Answering Reviewers-228K (164) | Received: 02/09/2021 | Revised: 04/05/2021 | Accepted: 08/11/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (4) | Total Visits (8410) | Similar Articles (9) | Timeline of Article Publication (5) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (777) | Core Tip (1158) | Article Highlights (714) | Full Article (HTML) (3397) | Figures (1-4) (403) | Tables (1-1) (393) | Full Article (PDF)-2822K (469) | Audio-312K (7) | Peer-Review Report-169K (136) | Answering Reviewers-114K (140) | Received: 02/18/2021 | Revised: 04/07/2021 | Accepted: 08/30/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (7) | Total Visits (10554) | Similar Articles (910) | Timeline of Article Publication (5) | Authors Evaluation (4) | Article Quality Tracking (0) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (739) | Core Tip (1186) | Full Article (HTML) (2444) | Figures (1-5) (391) | Full Article (PDF)-20913K (276) | Audio-466K (6) | Peer-Review Report-311K (105) | Answering Reviewers-557K (135) | Received: 03/19/2021 | Revised: 05/14/2021 | Accepted: 07/07/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (9171) | Similar Articles (4183) | Timeline of Article Publication (9) | Authors Evaluation (1) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (781) | Core Tip (742) | Full Article (HTML) (2564) | Figures (1-3) (424) | Tables (1-2) (359) | Full Article (PDF)-5370K (263) | Audio-3281K (9) | Peer-Review Report-199K (165) | Answering Reviewers-235K (230) | Received: 02/02/2021 | Revised: 06/18/2021 | Accepted: 08/16/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (7891) | Similar Articles (4169) | Timeline of Article Publication (6) | Authors Evaluation (3) | Article Quality Tracking (0) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (808) | Core Tip (854) | Full Article (HTML) (5972) | Figures (1-3) (554) | Full Article (PDF)-4536K (271) | Audio-720K (3) | Peer-Review Report-175K (119) | Answering Reviewers-54K (126) | Received: 05/26/2021 | Revised: 06/26/2021 | Accepted: 07/22/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (12139) | Similar Articles (4254) | Timeline of Article Publication (10) | Authors Evaluation (1) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (1087) | Core Tip (698) | Full Article (HTML) (2417) | Figures (1-3) (685) | Full Article (PDF)-9061K (313) | Audio-465K (4) | Peer-Review Report-598K (152) | Answering Reviewers-55K (151) | Received: 02/26/2021 | Revised: 05/17/2021 | Accepted: 08/09/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (8762) | Similar Articles (4210) | Timeline of Article Publication (7) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (792) | Core Tip (711) | Full Article (HTML) (3144) | Figures (1-4) (442) | Tables (1-2) (404) | Full Article (PDF)-11805K (289) | Audio-650K (7) | Peer-Review Report-201K (208) | Answering Reviewers-442K (142) | Received: 03/12/2021 | Revised: 07/05/2021 | Accepted: 08/18/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (8689) | Similar Articles (4172) | Timeline of Article Publication (6) | Authors Evaluation (1) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (1030) | Core Tip (693) | Full Article (HTML) (2428) | Figures (1-1) (384) | Full Article (PDF)-1812K (268) | Audio-195K (8) | Peer-Review Report-196K (140) | Answering Reviewers-211K (128) | Received: 04/01/2021 | Revised: 06/10/2021 | Accepted: 08/11/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (9449) | Similar Articles (5856) | Timeline of Article Publication (12) | Authors Evaluation (4) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (1191) | Core Tip (699) | Full Article (HTML) (2733) | Figures (1-4) (392) | Full Article (PDF)-8487K (308) | Audio-211K (4) | Peer-Review Report-166K (116) | Answering Reviewers-30K (121) | Received: 05/19/2021 | Revised: 06/27/2021 | Accepted: 07/30/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (8775) | Similar Articles (4201) | Timeline of Article Publication (11) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (858) | Core Tip (831) | Full Article (HTML) (1835) | Figures (1-1) (396) | Full Article (PDF)-3251K (230) | Audio-2328K (3) | Videos (1-3) (9) | Peer-Review Report-204K (116) | Answering Reviewers-106K (146) | Received: 03/29/2021 | Revised: 05/10/2021 | Accepted: 08/19/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (6690) | Similar Articles (4170) | Timeline of Article Publication (5) | Authors Evaluation (1) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (743) | Core Tip (688) | Full Article (HTML) (3518) | Figures (1-4) (430) | Tables (1-1) (410) | Full Article (PDF)-13762K (336) | Audio-504K (4) | Peer-Review Report-204K (165) | Answering Reviewers-231K (145) | Received: 04/05/2021 | Revised: 07/19/2021 | Accepted: 08/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (8918) | Similar Articles (4169) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (808) | Core Tip (714) | Full Article (HTML) (2676) | Figures (1-3) (511) | Full Article (PDF)-4177K (312) | Audio-397K (8) | Peer-Review Report-205K (139) | Answering Reviewers-78K (114) | Received: 04/06/2021 | Revised: 05/12/2021 | Accepted: 08/05/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (8380) | Similar Articles (4262) | Timeline of Article Publication (4) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (1262) | Core Tip (774) | Full Article (HTML) (5121) | Figures (1-1) (499) | Tables (1-1) (386) | Full Article (PDF)-1234K (359) | Audio-585K (13) | Peer-Review Report-152K (138) | Answering Reviewers-99K (153) | Received: 05/18/2021 | Revised: 06/30/2021 | Accepted: 08/02/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (11535) | Similar Articles (4195) | Timeline of Article Publication (3) | Authors Evaluation (6) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (709) | Core Tip (1136) | Full Article (HTML) (2260) | Figures (1-2) (413) | Full Article (PDF)-2261K (238) | Audio-1805K (3) | Peer-Review Report-196K (115) | Answering Reviewers-4K (112) | Received: 04/28/2021 | Revised: 05/26/2021 | Accepted: 08/12/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (4) | Total Visits (7927) | Similar Articles (4202) | Timeline of Article Publication (4) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (901) | Core Tip (653) | Full Article (HTML) (1889) | Figures (1-6) (418) | Tables (1-1) (854) | Full Article (PDF)-6607K (280) | Audio-1280K (5) | Peer-Review Report-240K (144) | Answering Reviewers-514K (141) | Received: 05/06/2021 | Revised: 06/19/2021 | Accepted: 08/06/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (9889) | Similar Articles (4175) | Timeline of Article Publication (3) | Authors Evaluation (1) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (747) | Core Tip (914) | Full Article (HTML) (2238) | Figures (1-4) (436) | Full Article (PDF)-3901K (293) | Audio-1219K (4) | Peer-Review Report-144K (148) | Answering Reviewers-74K (159) | Received: 05/18/2021 | Revised: 06/27/2021 | Accepted: 07/26/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (7835) | Similar Articles (4214) | Timeline of Article Publication (3) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (752) | Core Tip (746) | Full Article (HTML) (2610) | Figures (1-1) (389) | Full Article (PDF)-3249K (339) | Audio-771K (6) | Peer-Review Report-202K (159) | Answering Reviewers-36K (98) | Received: 05/27/2021 | Revised: 06/28/2021 | Accepted: 08/18/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (7) | Total Visits (7591) | Similar Articles (4169) | Timeline of Article Publication (5) | Authors Evaluation (1) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (722) | Core Tip (1072) | Full Article (HTML) (2401) | Figures (1-2) (390) | Full Article (PDF)-2966K (317) | Audio-1562K (2) | Peer-Review Report-216K (126) | Answering Reviewers-110K (159) | Received: 05/25/2021 | Revised: 06/23/2021 | Accepted: 08/09/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (7274) | Similar Articles (4169) | Timeline of Article Publication (3) | Authors Evaluation (2) | Article Quality Tracking (2) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (776) | Core Tip (1057) | Full Article (HTML) (2884) | Figures (1-3) (759) | Full Article (PDF)-3988K (293) | Audio-636K (4) | Peer-Review Report-465K (172) | Answering Reviewers-153K (122) | Supplementary Material-226K (130) | Received: 05/27/2021 | Revised: 06/28/2021 | Accepted: 08/02/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (5) | Total Visits (9758) | Similar Articles (4169) | Timeline of Article Publication (6) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (1) | Open

Abstract (774) | Core Tip (904) | Full Article (HTML) (2857) | Figures (1-3) (330) | Tables (1-1) (351) | Full Article (PDF)-3359K (328) | Audio-2535K (2) | Peer-Review Report-209K (136) | Answering Reviewers-72K (130) | Received: 05/17/2021 | Revised: 07/08/2021 | Accepted: 07/28/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (9194) | Similar Articles (4174) | Timeline of Article Publication (0) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (765) | Core Tip (925) | Full Article (HTML) (3202) | Figures (1-2) (510) | Full Article (PDF)-8746K (251) | Audio-1738K (6) | Peer-Review Report-218K (104) | Answering Reviewers-130K (99) | Received: 05/19/2021 | Revised: 07/05/2021 | Accepted: 07/19/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (4) | Total Visits (9013) | Similar Articles (4177) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (791) | Core Tip (618) | Full Article (HTML) (3465) | Figures (1-5) (609) | Full Article (PDF)-13057K (310) | Audio-264K (5) | Peer-Review Report-202K (142) | Answering Reviewers-66K (122) | Received: 05/25/2021 | Revised: 07/03/2021 | Accepted: 08/12/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (9367) | Similar Articles (4216) | Timeline of Article Publication (6) | Authors Evaluation (2) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (723) | Core Tip (763) | Full Article (HTML) (2542) | Figures (1-5) (389) | Tables (1-1) (409) | Full Article (PDF)-8336K (286) | Audio-614K (6) | Peer-Review Report-210K (196) | Answering Reviewers-131K (133) | Received: 05/25/2021 | Revised: 07/01/2021 | Accepted: 08/10/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (4) | Total Visits (8745) | Similar Articles (4184) | Timeline of Article Publication (5) | Authors Evaluation (5) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (712) | Core Tip (712) | Full Article (HTML) (2670) | Figures (1-2) (410) | Full Article (PDF)-5105K (292) | Audio-404K (4) | Peer-Review Report-197K (158) | Answering Reviewers-265K (126) | Received: 05/25/2021 | Revised: 07/08/2021 | Accepted: 08/12/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (7704) | Similar Articles (4178) | Timeline of Article Publication (5) | Authors Evaluation (3) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (677) | Core Tip (1175) | Full Article (HTML) (2209) | Figures (1-5) (294) | Full Article (PDF)-16471K (244) | Audio-759K (16) | Peer-Review Report-207K (97) | Answering Reviewers-111K (109) | Received: 05/26/2021 | Revised: 06/27/2021 | Accepted: 07/21/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (7501) | Similar Articles (4171) | Timeline of Article Publication (5) | Authors Evaluation (1) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open

Abstract (743) | Core Tip (598) | Full Article (HTML) (3438) | Figures (1-3) (297) | Tables (1-1) (425) | Full Article (PDF)-11719K (377) | Audio-1155K (8) | Peer-Review Report-156K (153) | Answering Reviewers-87K (131) | Received: 05/29/2021 | Revised: 06/22/2021 | Accepted: 08/06/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (8780) | Similar Articles (4169) | Timeline of Article Publication (8) | Authors Evaluation (1) | Article Quality Tracking (1) | What about the content of this article? (0) | Cite |  (0) | Open