BPG is committed to discovery and dissemination of knowledge
High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling  
Nipha Chaicharoenaudomrung, Phongsakorn Kunhorm, Parinya Noisa 
World J Stem Cells 11(12):1065-1083. Published online Dec 26, 2019. doi: 10.4252/wjsc.v11.i12.1065
2
Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy  
Justin D Glenn, Katharine A Whartenby 
World J Stem Cells 6(5):526-539. Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.526
3
Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells  
Anna Park, Won Kon Kim, Kwang-Hee Bae 
World J Stem Cells 6(1):33-42. Published online Jan 26, 2014. doi: 10.4252/wjsc.v6.i1.33
4
Secretion of immunoregulatory cytokines by mesenchymal stem cells  
Dobroslav Kyurkchiev, Ivan Bochev, Ekaterina Ivanova-Todorova, Milena Mourdjeva, Tsvetelina Oreshkova, Kalina Belemezova, Stanimir Kyurkchiev 
World J Stem Cells 6(5):552-570. Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.552
5
Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy?  
Ann De Becker, Ivan Van Riet 
World J Stem Cells 8(3):73-87. Published online Mar 26, 2016. doi: 10.4252/wjsc.v8.i3.73
6
Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts  
Maya Fakhry, Eva Hamade, Bassam Badran, René Buchet, David Magne 
World J Stem Cells 5(4):136-148. Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.136
7
Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility  
Tokiko Nagamura-Inoue, Haiping He 
World J Stem Cells 6(2):195-202. Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.195
8
Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases  
Chie Sugimoto, Hiroyoshi Fujita, Hiroshi Wakao 
World J Stem Cells 8(4):158-169. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.158
9
Cancer stem cell plasticity and tumor hierarchy  
Marina Carla Cabrera, Robert E Hollingsworth, Elaine M Hurt 
World J Stem Cells 7(1):27-36. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.27
10
Sox2, a key factor in the regulation of pluripotency and neural differentiation  
Shuchen Zhang, Wei Cui 
World J Stem Cells 6(3):305-311. Published online Jul 26, 2014. doi: 10.4252/wjsc.v6.i3.305
11
Epidermal stem cells and skin tissue engineering in hair follicle regeneration  
María Eugenia Balañá, Hernán Eduardo Charreau, Gustavo José Leirós 
World J Stem Cells 7(4):711-727. Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.711
12
13
Regenerative potential of mouse embryonic stem cell-derived PDGFRα+ cardiac lineage committed cells in infarcted myocardium  
Seon Pyo Hong, Sukhyun Song, Seungjoo Lee, Hyeonju Jo, Hyoung Kyu Kim, Jin Han, Jae-Hyeong Park, Sung Woo Cho 
World J Stem Cells 11(1):44-54. Published online Jan 26, 2019. doi: 10.4252/wjsc.v11.i1.44
14
Role of Hox genes in stem cell differentiation  
Anne Seifert, David F Werheid, Silvana M Knapp, Edda Tobiasch 
World J Stem Cells 7(3):583-595. Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.583
15
High frequency of CD34+CD38-/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia  
Adriana Plesa, Charles Dumontet, Eve Mattei, Ines Tagoug, Sandrine Hayette, Pierre Sujobert, Isabelle Tigaud, Marie Pierre Pages, Youcef Chelghoum, Fiorenza Baracco, Helene Labussierre, Sophie Ducastelle, Etienne Paubelle, Franck Emmanuel Nicolini, Mohamed Elhamri, Lydia Campos, Claudiu Plesa, Stéphane Morisset, Gilles Salles, Yves Bertrand, Mauricette Michallet, Xavier Thomas 
World J Stem Cells 9(12):227-234. Published online Dec 26, 2017. doi: 10.4252/wjsc.v9.i12.227
16
Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis in vitro and in vivo: From biological characteristics to therapeutic mechanisms  
Fei Yin, Wen-Ying Wang, Wen-Hua Jiang 
World J Stem Cells 11(8):548-564. Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.548
17
Neural stem cells could serve as a therapeutic material for age-related neurodegenerative diseases  
Sarawut Suksuphew, Parinya Noisa 
World J Stem Cells 7(2):502-511. Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.502
18
Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues  
Urszula Kozlowska, Agnieszka Krawczenko, Katarzyna Futoma, Tomasz Jurek, Marta Rorat, Dariusz Patrzalek, Aleksandra Klimczak 
World J Stem Cells 11(6):347-374. Published online Jun 26, 2019. doi: 10.4252/wjsc.v11.i6.347
19
Human dental pulp stem cells: Applications in future regenerative medicine  
Pravin D Potdar, Yogita D Jethmalani 
World J Stem Cells 7(5):839-851. Published online Jun 26, 2015. doi: 10.4252/wjsc.v7.i5.839
20
Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment  
Antonin Bukovsky 
World J Stem Cells 8(12):399-427. Published online Dec 26, 2016. doi: 10.4252/wjsc.v8.i12.399
21
Common stemness regulators of embryonic and cancer stem cells  
Christiana Hadjimichael, Konstantina Chanoumidou, Natalia Papadopoulou, Panagiota Arampatzi, Joseph Papamatheakis, Androniki Kretsovali 
World J Stem Cells 7(9):1150-1184. Published online Oct 26, 2015. doi: 10.4252/wjsc.v7.i9.1150
22
Triple-modal imaging of stem-cells labeled with multimodal nanoparticles, applied in a stroke model  
Helio Rodrigues da Silva, Javier Bustamante Mamani, Mariana Penteado Nucci, Leopoldo Penteado Nucci, Andrea Tiemi Kondo, Daianne Maciely Carvalho Fantacini, Lucas Eduardo Botelho de Souza, Virginia Picanço-Castro, Dimas Tadeu Covas, José Mauro Kutner, Fernando Anselmo de Oliveira, Nelson Hamerschlak, Lionel Fernel Gamarra 
World J Stem Cells 11(2):100-123. Published online Feb 26, 2019. doi: 10.4252/wjsc.v11.i2.100
23
Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse  
Stuart J Emmerson, Caroline E Gargett 
World J Stem Cells 8(5):202-215. Published online May 26, 2016. doi: 10.4252/wjsc.v8.i5.202
24
Application of mesenchymal stem cell therapy for the treatment of osteoarthritis of the knee: A concise review  
Ai-Tong Wang, Ying Feng, Hong-Hong Jia, Meng Zhao, Hao Yu 
World J Stem Cells 11(4):222-235. Published online Apr 26, 2019. doi: 10.4252/wjsc.v11.i4.222
25
Clinical trials using dental stem cells: 2022 update  
Wen-Peng Song, Lu-Yuan Jin, Meng-Di Zhu, Hao Wang, Deng-Sheng Xia 
World J Stem Cells 15(3):31-51. Published online Mar 26, 2023. doi: 10.4252/wjsc.v15.i3.31
26
Targeting cancer stem cells in drug discovery: Current state and future perspectives  
Fang-Yu Du, Qi-Fan Zhou, Wen-Jiao Sun, Guo-Liang Chen 
World J Stem Cells 11(7):398-420. Published online Jul 26, 2019. doi: 10.4252/wjsc.v11.i7.398
27
Augmenting peripheral nerve regeneration using stem cells: A review of current opinion  
Neil G Fairbairn, Amanda M Meppelink, Joanna Ng-Glazier, Mark A Randolph, Jonathan M Winograd 
World J Stem Cells 7(1):11-26. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.11
28
Structural properties of scaffolds: Crucial parameters towards stem cells differentiation  
Laleh Ghasemi-Mobarakeh, Molamma P Prabhakaran, Lingling Tian, Elham Shamirzaei-Jeshvaghani, Leila Dehghani, Seeram Ramakrishna 
World J Stem Cells 7(4):728-744. Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.728
29
Next-generation sequencing traces human induced pluripotent stem cell lines clonally generated from heterogeneous cancer tissue  
Tetsuya Ishikawa 
World J Stem Cells 9(5):77-88. Published online May 26, 2017. doi: 10.4252/wjsc.v9.i5.77
30
Epithelial-mesenchymal transition - activating transcription factors - multifunctional regulators in cancer  
Minal Garg 
World J Stem Cells 5(4):188-195. Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.188
31
Methods of induced pluripotent stem cells for clinical application  
Tomohisa Seki, Keiichi Fukuda 
World J Stem Cells 7(1):116-125. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.116
32
Migration of bone marrow progenitor cells in the adult brain of rats and rabbits  
Donnahue Dennie, Jean-Pierre Louboutin, David S Strayer 
World J Stem Cells 8(4):136-157. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.136
33
Rat model of anal sphincter injury and two approaches for stem cell administration  
Jacobo Trébol, Tihomir Georgiev-Hristov, Luz Vega-Clemente, Ignacio García-Gómez, Ana Carabias-Orgaz, Mariano García-Arranz, Damián García-Olmo 
World J Stem Cells 10(1):1-14. Published online Jan 26, 2018. doi: 10.4252/wjsc.v10.i1.1
34
Human induced pluripotent stem cells for monogenic disease modelling and therapy  
Paola Spitalieri, Valentina Rosa Talarico, Michela Murdocca, Giuseppe Novelli, Federica Sangiuolo 
World J Stem Cells 8(4):118-135. Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.118
35
Cancer stem cell impact on clinical oncology  
Mariel E Toledo-Guzmán, Gabriele D Bigoni-Ordóñez, Miguel Ibáñez Hernández, Elizabeth Ortiz-Sánchez 
World J Stem Cells 10(12):183-195. Published online Dec 26, 2018. doi: 10.4252/wjsc.v10.i12.183
36
Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders  
Qiang Liu, Mo-Xian Chen, Lin Sun, Chloe U Wallis, Jian-Song Zhou, Li-Juan Ao, Qi Li, Pak C Sham 
World J Stem Cells 11(2):55-72. Published online Feb 26, 2019. doi: 10.4252/wjsc.v11.i2.55
37
Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine  
Zhan-Jun Ma, Jing-Jing Yang, Yu-Bao Lu, Zhao-Yang Liu, Xue-Xi Wang 
World J Stem Cells 12(8):814-840. Published online Aug 26, 2020. doi: 10.4252/wjsc.v12.i8.814
38
Current progress in use of adipose derived stem cells in peripheral nerve regeneration  
Shomari DL Zack-Williams, Peter E Butler, Deepak M Kalaskar 
World J Stem Cells 7(1):51-64. Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.51
39
Immunomodulation by mesenchymal stem cells: Interplay between mesenchymal stem cells and regulatory lymphocytes  
Oscar Ka-Fai Ma, Koon Ho Chan 
World J Stem Cells 8(9):268-278. Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.268
40
Therapies targeting cancer stem cells: Current trends and future challenges  
Denisa L Dragu, Laura G Necula, Coralia Bleotu, Carmen C Diaconu, Mihaela Chivu-Economescu 
World J Stem Cells 7(9):1185-1201. Published online Oct 26, 2015. doi: 10.4252/wjsc.v7.i9.1185
41
Issues and opportunities of stem cell therapy in autoimmune diseases  
Györgyi Műzes, Ferenc Sipos 
World J Stem Cells 11(4):212-221. Published online Apr 26, 2019. doi: 10.4252/wjsc.v11.i4.212
42
Inducing human induced pluripotent stem cell differentiation through embryoid bodies: A practical and stable approach  
Ning-Ning Guo, Li-Ping Liu, Yun-Wen Zheng, Yu-Mei Li 
World J Stem Cells 12(1):25-34. Published online Jan 26, 2020. doi: 10.4252/wjsc.v12.i1.25
43
Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytes  
Pranav Machiraju, Steven C Greenway 
World J Stem Cells 11(1):33-43. Published online Jan 26, 2019. doi: 10.4252/wjsc.v11.i1.33
44
Early B lymphocyte development: Similarities and differences in human and mouse  
Michiko Ichii, Kenji Oritani, Yuzuru Kanakura 
World J Stem Cells 6(4):421-431. Published online Sep 26, 2014. doi: 10.4252/wjsc.v6.i4.421
45
Stromal cell-derived factor-1α promotes recruitment and differentiation of nucleus pulposus-derived stem cells  
Jin-Wei Ying, Tian-Yong Wen, Shi-Shen Pei, Ling-Hao Su, Di-Ke Ruan 
World J Stem Cells 11(3):196-211. Published online Mar 26, 2019. doi: 10.4252/wjsc.v11.i3.196
46
Amyotrophic lateral sclerosis as a protein level, non-genomic disease: Therapy with S2RM exosome released molecules  
Greg Maguire 
World J Stem Cells 9(11):187-202. Published online Nov 26, 2017. doi: 10.4252/wjsc.v9.i11.187
47
Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease  
Etsu Suzuki, Daishi Fujita, Masao Takahashi, Shigeyoshi Oba, Hiroaki Nishimatsu 
World J Stem Cells 8(9):297-305. Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.297
48
High tibial osteotomy with human umbilical cord blood-derived mesenchymal stem cells implantation for knee cartilage regeneration  
Jun-Seob Song, Ki-Taek Hong, Chae-Gwan Kong, Na-Min Kim, Jae-Yub Jung, Han-Soo Park, Young Ju Kim, Ki Bong Chang, Seok Jung Kim 
World J Stem Cells 12(6):514-526. Published online Jun 26, 2020. doi: 10.4252/wjsc.v12.i6.514
49
Adipose-derived stromal/stem cells from different adipose depots in obesity development  
Karina Ribeiro Silva, Leandra Santos Baptista 
World J Stem Cells 11(3):147-166. Published online Mar 26, 2019. doi: 10.4252/wjsc.v11.i3.147
50
Regeneration of the central nervous system-principles from brain regeneration in adult zebrafish  
Alessandro Zambusi, Jovica Ninkovic 
World J Stem Cells 12(1):8-24. Published online Jan 26, 2020. doi: 10.4252/wjsc.v12.i1.8