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Lin Z. Li, PhD, is a Research Associate Professor of Radiology and Director of the Britton Chance Laboratory of Redox Imaging at the Perelman School of Medicine, University of Pennsylvania. His research is dedicated to developing and applying magnetic resonance imaging and spectroscopy (MRI/MRS) and optical imaging techniques to investigate cellular metabolism and redox states in cancer, Alzheimer's disease, and aging with the overarching goal of identifying novel metabolic and redox biomarkers for disease diagnosis, prognosis, and treatment monitoring; what distinguishes his work is the unique integration of multiple complementary imaging modalities across scales and the pioneering role his laboratory has played in translating optical redox imaging from preclinical animal models and ex vivo tissue specimens toward in vivo human applications. Dr. Li has published more than 56 peer-reviewed articles as first or senior/corresponding author in leading journals including PNAS, NMR in Biomedicine, Journal of Biomedical Optics, Academic Radiology, and Molecular Imaging and Biology; has delivered more than 50 presentations at major national and international scientific conferences; has accumulated more than 3,300 citations with a Google Scholar H-index of 28; and has received numerous honors including the 2024 Peter Vaupel Honorary Lecture Award from the International Society on Oxygen Transport to Tissue (ISOTT), the Susan G. Komen Breast Cancer Foundation Career Catalyst Research Grant, and Top-10 Paper Awards from the Journal of Innovative Optical Health Sciences; he currently serves as Managing Director of ISOTT, having previously served as its President (2014–2015) and is an active member of SPIE, Sigma Xi, and the World Molecular Imaging Society. In service to the scholarly community, Dr. Li has peer-reviewed approximately 50 manuscripts for more than 30 international journals, and has served as Guest Editor for eight special issues and thematic sections across journals including the Journal of Innovative Optical Health Sciences, Academic Radiology, Journal of Biomedical Optics, and Antioxidants and Redox Signaling, in addition to serving on the editorial boards of multiple peer-reviewed journals. Dr. Li' s long-term research is primarily engaged in advancing noninvasive metabolic imaging methods, particularly label-free optical redox imaging and in vivo MRS to elucidate the bioenergetic mechanisms underlying cancer progression and neurodegeneration, with translational emphasis on developing early-detection and treatment-response biomarkers for triple-negative breast cancer and Alzheimer's disease. His distinctive professional strengths include exceptional interdisciplinary communication that bridges physics, engineering, biochemistry, and clinical medicine; active listening and collaborative problem-solving that have sustained productive research partnerships with oncologists, neurologists, and basic scientists across multiple institutions; effective leadership and management of a diverse, multi-generational research team encompassing postdoctoral fellows, graduate and undergraduate students, and visiting scholars from around the world; and a deep and sustained commitment to mentoring the next generation of imaging scientists, as evidenced by the many trainees he has guided from high school internships through postdoctoral training and independent faculty careers.
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