My name is Sien Lin, PhD, a Research Assistant Professor in the Chinese University of Hong Kong (CUHK). Over the past three years at CUHK, I have been fully committed to advancing the research field of skeletal tissue regeneration. My research interests include two key areas: 1) mechanoresponsive stem cells and immune cells in distraction osteogenesis; and 2) stem cells and functional biomaterials in bone or cartilage tissue engineering. My research on the basic and translational research on bone regeneration using very special animal models, bone lengthening/bone transport, which have been widely adopted in orthopaedic surgeries, while animal surgeries are very complicated. We are one of the most active reseach teams in the world in this research field. By working closely with a dedicated team, I have successfully published 96 peer-reviewed papers with H-index 34 and citation 4025 (Google Scholar) in the research field since 2013, including high-impact journals such as Nature Communications, Advanced Science, JACS and Bioactive Materials. My research has been supported by 3 GRF under RGC (21/22, 23/24, 24/25), 3 general-scheme of NSFC (2018, 2022, & 2024), and 1 CUHK direct grant (2023) as the Principal Investigator. I have given over 10 speeches in the annual meeting organized by International Chinese Musculoskeletal Research Society (ICMRS), Orthopaedic Research Society (ORS), and Tissue Engineering and Regenerative Medicine International Society (TERMIS). I am now serving as an Editorial Board Member of Journal of Orthopaedic Translation (JCR Q1), a Youth Editor of Military Medical Research (JCR Q1), a grant reviewer for NSFC, MRC (UK), and NWO (Dutch), and a reviewer for more than ten peer-reviewed journals (reviewed over 100 manuscripts). I have also published 2 editorials. I am dedicated to making meaningful contributions to the musculoskeletal research field. Our team is committed to studying the mechanism of distraction osteogenesis in order to explore innovative approaches for enhancing bone repair and regeneration. In this field, my research focuses on the role of periosteal stem cells (PSCs) and T cell populations during distraction osteogenesis. We aims to establish a crucial link between mechanical stimulation and PSCs-driven bone formation by elucidating the role of mechanotransductive signaling in both intramembranous and endochondral ossification. Additionally, we aim to unveil the mechanism of novel T cell subsets in regulating osteoblast differentiation during bone regneneration. I have enthusiastically built a robust network of national and international research partnerships. My collaborators are primarily based at top-tier universities, including Stanford University in the USA (QS top 5), Yonsei University in Korea (QS top 100). I have actively engaged in postgraduate and undergraduate teaching activities. As a research academic staff, I have supervised postgraduate students, including 3 PhD students in Orthopaedics and Traumatology, 5 MSc students in Musculoskeletal Medicine, Rehabilitation and Geriatric Orthopaedics and 7 MScs tudents in Biomedical Engineering. Running, hiking and music are my personal hobbies. I usually go hiking with my family or friends.