The scientific activity started with studies of amniotic cells for enzyme therapy of inherited lysosomal diseases, laying the foundations for cell therapies. Subsequently, she worked on developing new antineoplastic drugs based on nucleic acids able to form the exogenous triple helix of DNA or to act as aptamers in recognizing specific proteins. Her interest was also to highlight new molecular targets for the prevention, prognosis, and treatment of hematological, breast prostate, and colorectal cancers. She has two patents: Scaggiante Bruna, Quadrifoglio Franco: A class of oligonucleotides, therapeutically useful as anticancer agents. Saicom, Scaggiante Bruna, Quadrifoglio Franco June 12, 1997: WO / 1997/020924; Grassi Gabriele, Scaggiante Bruna: GT Aptamer Oligonucleotides and their use as anticancer agents. University of Trieste, GRASSI Gabriele, SCAGGIANTE Bruna March 22, 2012: WO / 2012/034969). She had a fruitful collaboration for DNA sensors with prof. Giacinto Scoles, professor emeritus of Princeton University USA, a study of van der Waals weak forces between atoms, molecules, and surfaces. Her studies were then focused on the differential expression of genes of the eEF1A protein family in human tumors and in particular in hematopoietic tumors, hepatocarcinoma, adenocarcinomas of the prostate, and breast. The molecular effects of aptameric oligonucleotides and siRNA in tumor cells for the development of potential drugs for the control of cell proliferation are also of interest. She is currently working on novel tumor markers and has developed analyzes of the eEF1A1 and eEF1A2 proteins to identify their diagnostic and prognostic potential in cancers. In addition, she deals with liquid biopsy with the digital droplet PCR system and the search for markers for the diagnosis and prognosis of solid tumors, in particular of the breast and prostate, starting from plasma circulating tumor DNA. As President of the Italian League for the Fight against Cancer of Trieste and member of the Italian League for the Fight against Cancer, a public body of considerable importance that works in conjunction and synergy with the Ministry of Health, she was responsible for promoting clinical studies on the role of primary, secondary and tertiary prevention to reduce the incidence and mortality of cancers, in particular of the breast. In addition, with this role, she has been involved in promoting education in correct lifestyles for oncological prevention and improving the quality of life of cancer survivors in collaboration with public institutions and Integrated University Health Authorities of the Friuli Venezia Giulia region.