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Contents Volume 18 Issue 5 May 15, 2026
Editorial
From bile acids to yes-associated protein: A bidirectional switch for cholangiocarcinoma therapy
Shu-Yuan Zhang, Hui Yu, Yin Mi, Fan-Kai Xiao 
World J Gastrointest Oncol 18(5):117990. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117990
Opinion Review
Inhibiting exosomal miR-191 can induce ferroptosis in macrophages, thereby delaying the progression of colorectal cancer
Zi-Wei Wang, Li Jia, Ling-Ke Qu, Guo-Hua Gong 
World J Gastrointest Oncol 18(5):116881. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116881
Protein induced by vitamin K absence or antagonist-II in hepatocellular carcinoma with normal alpha-fetoprotein: Current advances and controversies
Xi-Ming Wang, Hui-Gang Li, Jin-Xin Xu, Xiang Wu, Hong Li 
World J Gastrointest Oncol 18(5):118297. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.118297
Review
Evolution of non-invasive colorectal neoplasm detection
Sun Jung Kim, Tae-Gyun Lee, Jin-Min Jung, Chang Woo Kim 
World J Gastrointest Oncol 18(5):115681. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.115681
Advancing human epidermal growth factor receptor 2-positive gastric cancer therapy: Toward targeted immunotherapy and antibody-drug conjugates
Jia-Ju Xu, Chun-Xiao Ni, Ping Wang, Li-Dong Qin, Jia-Ju Xu 
World J Gastrointest Oncol 18(5):116882. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116882
Converting cold to hot: Strategies to sensitize microsatellite-stable colorectal cancer to immunotherapy
Feng Chi, Chi-Bo Liu, Jian Li, Xian-Wu Xia, Qian-Jin Hua, Wei Wang 
World J Gastrointest Oncol 18(5):118319. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.118319
Minireviews
Hyperthermic intraperitoneal chemotherapy for preventing and treating peritoneal metastasis in gastric cancer
Yi-Hao Niu, Sheng-Ming Shi, Yong-Xia Chen, Ji-You Kou 
World J Gastrointest Oncol 18(5):117098. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117098
Case Control Study
Diagnostic and prognostic values of pancreatic juice carbohydrate antigen 19-9 and carcinoembryonic antigen levels in patients with pancreatic cancer
Bojan Trogrlić, Zrinka Požgain, Goran Augustin, Borna Kovačić, Dejan Hil, Ivan Šerić, Veronika Šikić 
World J Gastrointest Oncol 18(5):119610. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.119610
Retrospective Cohort Study
Preoperative spectral computed tomography multi-parameter prediction of postoperative complications in colorectal cancer: A single-center retrospective cohort study
Rui Duan, Hong-Lian Li, Li Deng, Qing Zhao, Rong-Wei Yang, Zhi-Lin Wu 
World J Gastrointest Oncol 18(5):115303. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.115303
Prognosis of signet-ring cell carcinoma after proximal gastrectomy was comparable to total gastrectomy but with better nutrition status
Shun-Da Wang, Ya-Zhou Chang, Shi-Kang Ding, Zhi-Min Bian, Yi-Bin Xie 
World J Gastrointest Oncol 18(5):117410. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117410
Baseline and longitudinal biomarkers predict hepatocellular carcinoma in chronic hepatitis C: A cohort study
Yi-Lin Li, Hung-Da Tung, Tang-Wei Chuang, Chun-Ta Cheng, Mai-Gio Pang, Jyh-Jou Chen, Kun-Ming Zhong, Ting-Yi Huang, Pei-Lun Lee 
World J Gastrointest Oncol 18(5):117512. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117512
Assessing hepatocellular carcinoma in Nigeria: A multicenter retrospective cohort review of prevalence, risk factors, and treatment outcomes
Yusuf Musa, Nasiru Altine Dankiri, Habib Tijjani Saleh, Chinwe Philomena Onyia, Lukman Olaitan Abdulkareem, Kenechukwu C Okonkwo, Fatimah Biade Abdulkareem, Rukayya Babale Shu'aibu, Abubakar Sadiq Aminu, Adamu Mohammad Ewa, Hafizu Zubairu Abdullahi, Adiri Winnifred Njideka, Hassan Ishaq Sunusi, Uchenna N Ijoma, Nduka Vitus Sunday, Evaristus Sunday Chukwudike, Uchenna F Okeke, Promise Udoka Asogwa, George Duke Mukoro, Muhammad Kabir Abdullahi, Emuobor A Odeghe, Chinenye Nwoko, Isa M Takwashe, Oluwatosin Oluwagbenga Oguntoye, Opeyemi Olubukola Owoseni, Aminat Oluwabukola Jimoh, Ganiyat Kikelomo Oyeleke 
World J Gastrointest Oncol 18(5):117654. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117654
Retrospective Study
Comprehensive geriatric assessment guiding treatment and survival in elderly digestive tumor patients: A retrospective study
Lei Zhu, Xiao-Feng Liu 
World J Gastrointest Oncol 18(5):116640. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116640
Severe hepatic steatosis as a protective prognostic factor in combined hepatocellular-cholangiocarcinoma: A multicenter pathological study
Han Wang, Zhen-Ying Cao, Chun-Yan Xia, Xia Sheng, Yun Zhao, Hong-Zhen Chen, Wen-Ming Cong, Miao-Xia He, Hui Dong 
World J Gastrointest Oncol 18(5):116764. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116764
Characteristics and prognosis of primary gastric adenosquamous carcinoma: A multicenter retrospective study based on propensity score matching
Yi-Wen Chen, Zhong-Yi Dong, Xin-Xin Wang, Yi Cao, Jian-Xian Lin, Hao Chen, Hao-Yu Zhang, Yong-Biao Xiao, Guo-Xin Li, Zheng-Rong Li, Lin Chen, Xiang Xia, Zi-Zhen Zhang 
World J Gastrointest Oncol 18(5):117580. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117580
Randomized Controlled Trial
Impact of sintilimab with first-line therapy on tumor marker response in advanced gastric cancer
Hong-Liang Quan, Lin Xia, Yan Hu, Gui-Yuan Wang, Chao Wang 
World J Gastrointest Oncol 18(5):117085. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117085
Basic Study
Icaritin suppresses colorectal cancer invasion and metastasis through regulation of epithelial-mesenchymal transition and the Wnt/β-catenin signaling pathway
Xiang Li, Yan-Jiao Li, Dan-Dan Ren, Mei Yuan, Ya-Ru Qi, Hui-Wen Li, Yi Zhang, Ruo-Yu Wang 
World J Gastrointest Oncol 18(5):115697. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.115697
ELF3 emerges as a novel prognostic indicator implicated in gastric cancer progression and correlated with unfavorable clinical outcomes
Zong-Sheng Sun, Chang-Lei Li, Han-Hui Jing, Zheng-Zhao Wang, Long-Bo Zheng 
World J Gastrointest Oncol 18(5):116163. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116163
Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis: Insights into its anti-inflammatory and antinociceptive activities
Paola B Da Silva, Laís Lopes-Bute, Janaína Fischer, Ana P Parcianello, Renata Pires-Duarte, Rafael M Luiz, Ana P C Brandalize, Fabrício F Melo, Cinthia F Wendel, Kádima N Teixeira, Ana C Zarpelon-Schutz 
World J Gastrointest Oncol 18(5):116568. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116568
Metastasis-associated colon cancer 1 drives pancreatic cancer via p53/Notch signaling
Lin Cong, Si Tong, Yu-Jie Xu, De-Yu Zhang, Xiu-Mei Zhang, Hong Yu 
World J Gastrointest Oncol 18(5):117323. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117323
FNDC5 enhances quercetin-induced anoikis in pancreatic adenocarcinoma cells via focal adhesion kinase-dependent mechanisms
Hui-Feng Gao, Ke Zhang, Chien-Shan Cheng, Ye-Hua Shen, Hao Chen 
World J Gastrointest Oncol 18(5):118849. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.118849
Case Report
Colonic adenocarcinoma in a pediatric patient: A case report and review of literature
Marwh G Aldriwesh, Areej Alhareeri, Abdulrahman Alswaji, Maymunah Hakami, Roua Almatrafi, Ayyob Alqarni, Mohammed Alhalafi, Nahar A Alselaim, Mohammed Algarni, Homoud Gh Alawfi, Mohammad Bosaeed, Musaad Altammami, Majed F Alghoribi 
World J Gastrointest Oncol 18(5):116316. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116316
Successful seven-year management of recurrent adult pancreatoblastoma with liver metastasis: A case report
Shui-Guo Tang, Xiang-Ling Wei, Rong-Ji Ye, Hao-Qing Xu, Shu-Hao Shang, Yu-Xuan Han, Lin-Wei Wu, Wu-Zheng Xia 
World J Gastrointest Oncol 18(5):116776. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116776
Correspondence
Letter to the Editor: Integrating immune-related metrics with personalize first-line immunochemotherapy in human epidermal growth factor receptor 2-negative advanced gastric cancer
Yu-Han Yang 
World J Gastrointest Oncol 18(5):116411. Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.116411
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