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Contents Volume 18 Issue 4 April 15, 2026
Editorial
Digital polymerase chain reaction detection of telomerase reverse transcriptase promoter mutations in hepatitis B virus related hepatocellular carcinoma
Shuai Shao, Yu Xiong, Mo-Wei Kong, Yang Yu, Chun-Xiang Zhang 
World J Gastrointest Oncol 18(4):116504. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116504
Review
Could deciphering cellular-mesenchymal epithelial transition factor/hepatocyte growth factor network dynamics unlock novel biomarker-driven therapies for colorectal cancer?
Jun-Kai Wen, Jing Xia, Lu Yu, Guo-Liang Xu, Gang-Fu Ye, Yu-Hua Lin 
World J Gastrointest Oncol 18(4):114567. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.114567
Colorectal cancer therapy and nutrition: From ultra-processed consumption to metabolic reprogramming
Rodrigo Soares Pereira Lima, Jheniffer da Silva Sousa, Maria Shelda de Oliveira Neres, Dallyla Jennifer Morais de Sousa, Jorddam Almondes Martins, Irislene Costa Pereira, Alda Cássia Alves da Silva, Juliana Soares Severo, Francisco Leonardo Torres-Leal, Moisés Tolentino Bento da Silva 
World J Gastrointest Oncol 18(4):115511. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115511
Role of hematological parameters in pancreatic cancer: A literature review
Tamoor Jamil, Khowla Anis, Ayesha Rehman, Sadia Iqbal, Sumaira Pervaiz, Muhammad Irfan Latif, Ramsha Hafeez, Huma Khurshid, Saira Rafaqat 
World J Gastrointest Oncol 18(4):117765. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.117765
Minireviews
What does the surgeon need to know about microsatellite instability in gastric cancers?
Paulo Pimentel de Assumpção, Geraldo Ishak, Paula Baraúna de Assumpção, Samir Mansour Moraes Casseb, João Felipe Acioli, Sérgio Augusto Antunes Ramos, Jéssica Manoelli Costa Silva, Kauê Sant'Ana Pereira Guimarães, Carolina Baraúna de Assumpção, Paulo Kassab, Paul Mansfield 
World J Gastrointest Oncol 18(4):115719. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115719
Retrospective Cohort Study
Deep learning radiomics nomogram based on multi-regional features for predicting lymph node metastasis and prognosis in colorectal cancer
Xue-Di Lei, Gui-Xiang Qian, Zhi-Gang Sun, Zi-Qi Tang, Yuan-Cheng Liu, Rui Du, Yong-Hai Li 
World J Gastrointest Oncol 18(4):115635. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115635
Retrospective Study
Value of gastric cancer clinical decision support system in a single-center clinical application
Tian-Li Chen, Xi-Qiu Yu 
World J Gastrointest Oncol 18(4):115146. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115146
Hepatocellular carcinoma in F0 livers: Clinical and prognostic insights
Mizuki Endo, Koichi Honda, Tomoko Tokumaru, Tomoko Saito, Takuro Uchida, Masao Iwao, Mie Arakawa, Masataka Seike, Masaaki Kodama, Takashi Masuda, Yuichi Endo, Masafumi Inomata, Kazunari Murakami, Kazuhiro Mizukami 
World J Gastrointest Oncol 18(4):115576. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115576
Clinical prediction of carcinoembryonic antigen combined with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for postoperative survival in colorectal cancer
Tao Wang, Chang Liu, Jun Jiang 
World J Gastrointest Oncol 18(4):115687. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115687
Impact of multimodal rehabilitation on physical function in post-intensive care syndrome patients after gastrointestinal tumor surgery
Jing Chen, Ai-Qin Zhang 
World J Gastrointest Oncol 18(4):116420. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116420
Diagnostic value of serum chitinase-3-like protein 1 for liver fibrosis/cirrhosis and hepatocellular carcinoma
Hai-Ying Zhang, Run-Ling Zhang, Yu-Yuan Jia, Yan Liu, Ling Zhu, Feng Liu, Hui-Ying Rao 
World J Gastrointest Oncol 18(4):116821. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116821
Association of carcinoembryonic antigen/carbohydrate antigen 19-9 with gastric cancer recurrence and chemotherapy toxicities
Yue Qi, Chen-Xuan Wu 
World J Gastrointest Oncol 18(4):117498. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.117498
Prospective Study
Upper gastrointestinal endoscopic screening serves as a primary prevention approach by reducing modifiable risk factors
Xiang-Wen Cheng, Zhen Liu, Chuan-Hai Guo, Feng-Lei Li, Ya-Qi Pan, Ying Liu, Fang-Fang Liu, Huan-Yu Chen, Wen-Lei Yang, Hong-Rui Tian, Chao Shi, Zhong-Hu He, Meng-Fei Liu, Yang Ke 
World J Gastrointest Oncol 18(4):116949. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116949
Randomized Controlled Trial
Integration of the PIPOST model with early enteral nutrition to enhance postoperative rehabilitation in colorectal cancer patients
Xiao-Mei Chang, Bing-Hua Cai, Hai-Bin Zheng 
World J Gastrointest Oncol 18(4):115485. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115485
Effect of the Internet+ 5A nursing model on patients with middle- and late-stage digestive tract tumors pain
Lei Wang, Xiao-Qin Ma, Chen-Xia Ju, Jue Fu 
World J Gastrointest Oncol 18(4):116137. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116137
Basic Study
HMGCR loss is synthetic lethal with PIK3CD inhibition in colorectal cancer cells
Jin-Hui Huang, Jin-Qi Ma 
World J Gastrointest Oncol 18(4):114220. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.114220
CD161+CD8+ T cells in patients with hepatitis B virus-associated hepatocellular carcinoma
Chen-Rui Liu, Meng Zhang, Mu-Qi Wang, Wen Zhang, Jin Li, Gao-Zhao Shi, Fan-Fan Liang, Ya-Ping Li, Na Huang 
World J Gastrointest Oncol 18(4):114547. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.114547
Morphological and functional responses of three-dimensional-cultured colorectal cancer spheres to anticancer drugs
Yusuke Yoshimura, Seiichi Shinji, Yutaro Ogawa, Takeshi Yamada, Akihisa Matsuda, Kay Uehara, Yasuyuki Yokoyama, Goro Takahashi, Takuma Iwai, Toshimitsu Miyasaka, Shintaro Kanaka, Takanori Matsui, Koki Hayashi, Masakazu Fujiwara, Yuuki Shichi, Tomio Arai, Toshiyuki Ishiwata, Hiroshi Yoshida 
World J Gastrointest Oncol 18(4):116097. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116097
MicroRNA-206 suppresses hypoxia-inducible factor-1α/PFKFB3-mediated glycolysis to inhibit recurrence and metastasis of hepatocellular carcinoma after incomplete radiofrequency ablation
Dong Lu, Li-Jun Wang, Jie Chai, Jun Jiang, Yan-Lin Tang 
World J Gastrointest Oncol 18(4):116104. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116104
Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis
Xin-Fang Zhang, Guan-Hua Lv, Shu-Jian An, Xi-Ran Yang, Wen-Zhao Guo, Chen-Yang Yu, Cheng-Hui Zhu 
World J Gastrointest Oncol 18(4):117815. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.117815
Systematic Reviews
Cost-effectiveness analysis of seven treatments vs sorafenib as first-line therapy for advanced hepatocellular carcinoma in China
Zhi-Huan Lin, Yan He, Hai-Xia Xu, Liang Xiao 
World J Gastrointest Oncol 18(4):113266. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.113266
Case Report
Triple gastrointestinal malignancies with tumor-to-tumor metastasis from gastric adenocarcinoma to small bowel adenocarcinoma: A case report
Abdullah Saleh AlQattan, Lujain Binkhamis, Mohammed S Foula, Alaa Alsalim, Waleed Mohammed Alselwi, Ali Ahmad Alzahir 
World J Gastrointest Oncol 18(4):115614. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.115614
Occult intestinal angiosarcoma presenting as refractory anemia during tyrosine kinase inhibitor therapy for chronic myeloid leukemia: A case report
Tala Najdi, Samah Seif, Diana Khoury, Antony Kahwagi, Perla Wehbe, Rita Karam, Layal El Halabi, Rita Slim, Ghassan Chakhtoura, Viviane Trak, Roland Eid 
World J Gastrointest Oncol 18(4):116365. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116365
Uncommon hepatocellular carcinoma in a non-cirrhotic woman with chronic hepatitis B virus infection after medical assisted reproduction: A case report
Clelia Asero, Giuliana Ciappina, Maria Stella Franzè, Teresa Maltese, Salvatore Gruttadauria, Duilio Pagano, Daniele Lombardo, Alessia Pitrone, Cristina Musolino, Massimiliano Berretta, Irene Cacciola 
World J Gastrointest Oncol 18(4):116955. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.116955
Correspondence
Letter to the Editor: Toward better mortality prediction in intensive care unit-admitted colorectal cancer patients
Marco Diaz-Cordova, Ishani Sharma, Kenji Okumura 
World J Gastrointest Oncol 18(4):114373. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.114373
Correction
Correction to “Impact of Alcian blue and periodic acid Schiff expression on the prognosis of gastric signet ring cell carcinoma”
Juan Lin, Zhu-Feng Chen, Guo-Dong Guo, Xin Chen 
World J Gastrointest Oncol 18(4):118402. Published online Apr 15, 2026. doi: 10.4251/wjgo.v18.i4.118402
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