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Contents Volume 18 Issue 8 August 27, 2026
Editorial
Hepatic ischemia reperfusion injury: Understanding the little components of the larger picture
Eyad Abdulrazzak, Eric R Kallwitz 
World J Hepatol 18(8):117012. Published online Aug 27, 2026. doi: 10.4254/wjh.117012
Beyond efficacy: Insights from the norursodeoxycholic acid phase III trial in metabolic dysfunction-associated steatotic liver disease
Ling-Ying Yu, Xian-Feng Zhang 
World J Hepatol 18(8):117543. Published online Aug 27, 2026. doi: 10.4254/wjh.117543
Opinion Review
Chrono-metabolic regulation of hepatic fibrosis via NR1D1-mediated hepatic stellate cell activation
Hou-Shu Tu, Meng-Lin Chen, Jing Hong, Ling He 
World J Hepatol 18(8):118194. Published online Aug 27, 2026. doi: 10.4254/wjh.118194
Review
Second-line treatment of primary biliary cholangitis: To whom, which molecule, and when
Sylvia Drazilova, Peter Jarcuska, Tomas Koky, Martin Harhovsky, Slavomira Komarova, Jan Vasil, Martin Janicko 
World J Hepatol 18(8):121491. Published online Aug 27, 2026. doi: 10.4254/wjh.121491
Peribiliary and colonic crypt glands in primary sclerosing cholangitis and inflammatory bowel disease pathogenesis: New research perspectives
Vasiliy Ivanovich Reshetnyak, Alexandra Andreevna Reshetnyak, Igor Veniaminovich Maev 
World J Hepatol 18(8):123377. Published online Aug 27, 2026. doi: 10.4254/wjh.123377
Minireviews
Hepatic hydatid cyst disease in low- and middle-income countries: Spectrum of imaging findings and complications
Kumail Khandwala, Mariam Sajjad, Zainab Hussain, Mohammad Zeeshan, Kiran Hilal 
World J Hepatol 18(8):123946. Published online Aug 27, 2026. doi: 10.4254/wjh.123946
Metabolic dysfunction-associated steatotic liver disease and the consequence of extra-hepatic malignancy
Benjamin Blaske, Michael Ward, Ragesh Babu Thandassery 
World J Hepatol 18(8):124224. Published online Aug 27, 2026. doi: 10.4254/wjh.124224
Retrospective Study
Examination of bone mineral density in patients with varied liver diseases - a cross-sectional study
Oliver Rohland, Lysann Schwarzer, Laura Schwenk, Nicola Pollmann, Aladdin Ali Deeb, Utz Settmacher, Falk Rauchfuss, Felix Dondorf, Karin Amrein, Roland Kocijan, Michael Ardelt 
World J Hepatol 18(8):120697. Published online Aug 27, 2026. doi: 10.4254/wjh.120697
Acute hepatitis B in the vaccination era: Predictors of functional cure and chronicity
David Yardeni, Julianna Gershbaum Tobin, Bryan Itkowitz, Inna Lipnizkiy, Ali Abu Juma’a, Naim Abu-Freha, Ayelet Keren-Naus, May Turgeman, Anat Nevo-Shor, Robert Gareth Gish, Ohad Etzion 
World J Hepatol 18(8):124108. Published online Aug 27, 2026. doi: 10.4254/wjh.124108
Age-male-albumin-bilirubin-platelet score stratifies hepatocellular carcinoma risk after sustained virological response in hepatitis C-related compensated advanced chronic liver disease
Sirajuk Khongviwatsathien, Tawesak Tanwandee 
World J Hepatol 18(8):124474. Published online Aug 27, 2026. doi: 10.4254/wjh.124474
Clinical Trials Study
Effect of hepatic venous pressure gradient in different hepatic venous branches on assessing portal hypertension in cirrhotic patients
Yi-Fei Huang, Xiao-Qin Wu, Yi-Dong Yang, Bi-Lun Ke, Jin-Ni Luo, Bo-Yang Chang, Chu-Ren Zhou, Xiao-Li Huang, Xue-Mei Pan, Xue-Mei Lai, Li-Jun Zhang, Chun Wu, Bin Wu 
World J Hepatol 18(8):123580. Published online Aug 27, 2026. doi: 10.4254/wjh.123580
Observational Study
Prevalence and risk factors for metabolic dysfunction-associated steatotic liver disease and fibrosis in recently diagnosed type 2 diabetes
Astrid Ruiz-Margáin, Oscar Manuel Fierro-Angulo, José Alberto González-Regueiro, Sergio Cesar Hernández-Jiménez, Ana Cristina García-Ulloa, Victoria Landa-Anell, Fernando Bril, Berenice Montserrat Roman-Calleja, Regina Romo-Arellano, Ariana Pereira-García, Naga Chalasani, Ricardo Ulises Macías-Rodríguez 
World J Hepatol 18(8):123278. Published online Aug 27, 2026. doi: 10.4254/wjh.123278
Small dense low-density lipoprotein in primary biliary cholangitis: Independent association with metabolic syndrome
Tomas Koky, Sylvia Drazilova, Martin Janicko, Martin Harhovsky, Beata Hubkova, Ivana Tothova, Miroslava Rabajdova, Maria Marekova, Peter Jarcuska 
World J Hepatol 18(8):124436. Published online Aug 27, 2026. doi: 10.4254/wjh.124436
Basic Study
Suppression of the STAT3/MYC/MCL-1 pathway by the fixed Jianpi Huoxue Formula relieves early biochemical abnormalities in liver fibrosis
Long Huang, Cheng-Gui Wu, Teng-Fei Zhu, Qing-Lin Li, Qing-Sheng Yu, Qi Zhang, Yi Shen 
World J Hepatol 18(8):122262. Published online Aug 27, 2026. doi: 10.4254/wjh.122262
Correspondence
Letter to the Editor: Natural product intervention in metabolic dysfunction-associated steatotic liver disease: From allyl isothiocyanate to signaling networks
Rui Tian, Yi-Xin Wu, Jie-Yu Guo, Xing-Zhen Chen, Jing-Feng Tang, Ce-Fan Zhou 
World J Hepatol 18(8):117382. Published online Aug 27, 2026. doi: 10.4254/wjh.117382
Letter to the Editor: Filling the gaps in non-invasive assessment of liver fibrosis in metabolic dysfunction-associated steatotic liver disease
Roberta Forlano, Nicola Maurizio Castellaneta, Patrizia Suppressa 
World J Hepatol 18(8):117777. Published online Aug 27, 2026. doi: 10.4254/wjh.117777
Letter to the Editor: Efficacy and safety of the generic forms of sofosbuvir/ledipasvir in chronic hepatitis C virus adolescents in Upper Egypt
Nahed A Makhlouf 
World J Hepatol 18(8):118661. Published online Aug 27, 2026. doi: 10.4254/wjh.118661
Letter to the Editor: Induction immunotherapy in hyperimmunized liver transplantation: Rebalancing immunological risk and graft protection
Jin-Wei Zhang 
World J Hepatol 18(8):118687. Published online Aug 27, 2026. doi: 10.4254/wjh.118687
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