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High Impact Articles
High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads.
Rank Full Article
1
Cost effectiveness of intensive care in a low resource setting: A prospective cohort of medical critically ill patients  
Hajrunisa Cubro, Rabija Somun-Kapetanovic, Guillaume Thiery, Daniel Talmor, Ognjen Gajic 
World J Crit Care Med 5(2):150-164. Published online May 4, 2016. doi: 10.5492/wjccm.v5.i2.150
2
Cough as a neurological sign: What a clinician should know  
Mohammed Al-Biltagi, Adel Salah Bediwy, Nermin Kamal Saeed 
World J Crit Care Med 11(3):115-128. Published online May 9, 2022. doi: 10.5492/wjccm.v11.i3.115
3
Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review  
Vasilios Koulouras, Georgios Papathanakos, Athanasios Papathanasiou, Georgios Nakos 
World J Crit Care Med 5(2):121-136. Published online May 4, 2016. doi: 10.5492/wjccm.v5.i2.121
4
Point of care venous Doppler ultrasound: Exploring the missing piece of bedside hemodynamic assessment  
Abhilash Koratala, Eduardo R Argaiz, Carlos Gasca, Pablo Galindo 
World J Crit Care Med 10(6):310-322. Published online Nov 9, 2021. doi: 10.5492/wjccm.v10.i6.310
5
Focus on peripherally inserted central catheters in critically ill patients  
Mauro Pittiruti, Paolo Cotogni 
World J Crit Care Med 3(4):80-94. Published online Nov 4, 2014. doi: 10.5492/wjccm.v3.i4.80
6
Vitamin C in the critically ill - indications and controversies  
Edward A Bittner, Christoph S Nabzdyk 
World J Crit Care Med 7(5):52-61. Published online Oct 16, 2018. doi: 10.5492/wjccm.v7.i5.52
7
Management of gastrointestinal bleed in the intensive care setting, an updated literature review  
Ayrton I Bangolo, Jonathan Weinberger, Simcha Weissman, Shawn Philip, Nazir Ahmed, Colin Westman, Amer Jarri, Chinmay Trivedi, Namrata Nikum, Ritvik Sethi, Tannishtha Sethi, Lokeash Subramani Shobana, Sanket Bhattarai, Jaber Musalli, Charlene Mansour, Daniel Elias, Hadrian Hoang-Vu Tran, Gomathy Aarthy Nageswaran, Shruthi Badam, Emelyn Martinez, Ruchi Bhuju, Sai Priyanka Pulipaka, Vignesh K Nagesh 
World J Crit Care Med 14(1):101639. Published online Mar 9, 2025. doi: 10.5492/wjccm.v14.i1.101639
8
Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis  
Lukas Buendgens, Alexander Koch, Frank Tacke 
World J Crit Care Med 5(1):57-64. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.57
9
Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome  
Alpha A Fowler III, Christin Kim, Lawrence Lepler, Rajiv Malhotra, Orlando Debesa, Ramesh Natarajan, Bernard J Fisher, Aamer Syed, Christine DeWilde, Anna Priday, Vigneshwar Kasirajan 
World J Crit Care Med 6(1):85-90. Published online Feb 4, 2017. doi: 10.5492/wjccm.v6.i1.85
10
Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock  
Jihad Mallat, Malcolm Lemyze, Laurent Tronchon, Benoît Vallet, Didier Thevenin 
World J Crit Care Med 5(1):47-56. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.47
11
Effects of intrapulmonary percussive ventilation on airway mucus clearance: A bench model  
Ruben Restrepo, Jay Peters, Marcos I Restrepo, Bravein Amalakuhan, Lauren Shaffer, Lorena Fernandez-Restrepo 
World J Crit Care Med 6(3):164-171. Published online Aug 4, 2017. doi: 10.5492/wjccm.v6.i3.164
12
Point-of-care ultrasound for critically-ill patients: A mini-review of key diagnostic features and protocols  
Kay Choong See, Yie Hui Lau 
World J Crit Care Med 11(2):70-84. Published online Mar 9, 2022. doi: 10.5492/wjccm.v11.i2.70
13
Biomarkers in sepsis-looking for the Holy Grail or chasing a mirage!  
Neelmani Ahuja, Anjali Mishra, Ruchi Gupta, Sumit Ray 
World J Crit Care Med 12(4):188-203. Published online Sep 9, 2023. doi: 10.5492/wjccm.v12.i4.188
14
Plasma-Lyte 148: A clinical review  
Rinaldo Bellomo, Chong Tan, Kiara Van Mourik, Neil Collins, Laurence Weinberg 
World J Crit Care Med 5(4):235-250. Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.235
15
Fluid and electrolyte overload in critically ill patients: An overview  
Bruno Adler Maccagnan Pinheiro Besen, André Luiz Nunes Gobatto, Lívia Maria Garcia Melro, Alexandre Toledo Maciel, Marcelo Park 
World J Crit Care Med 4(2):116-129. Published online May 4, 2015. doi: 10.5492/wjccm.v4.i2.116
16
Recruitment maneuvers in acute respiratory distress syndrome: The safe way is the best way  
Raquel S Santos, Pedro L Silva, Paolo Pelosi, Patricia RM Rocco 
World J Crit Care Med 4(4):278-286. Published online Nov 4, 2015. doi: 10.5492/wjccm.v4.i4.278
17
18
Tumor lysis syndrome: A clinical review  
Aibek E Mirrakhimov, Prakruthi Voore, Maliha Khan, Alaa M Ali 
World J Crit Care Med 4(2):130-138. Published online May 4, 2015. doi: 10.5492/wjccm.v4.i2.130
19
Severe trauma in the geriatric population  
Joan Maria Raurich, Marcelino Sánchez-Casado, Mario Chico-Fernández, Jon Pérez-Bárcena, Juan Antonio Llompart-Pou 
World J Crit Care Med 6(2):99-106. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.99
20
Implementation of enteral feeding protocol in an intensive care unit: Before-and-after study  
Martin Padar, Gerli Uusvel, Liis Starkopf, Joel Starkopf, Annika Reintam Blaser 
World J Crit Care Med 6(1):56-64. Published online Feb 4, 2017. doi: 10.5492/wjccm.v6.i1.56
21
Steps to consider in the approach and management of critically ill patient with spontaneous intracerebral hemorrhage  
Daniel Agustin Godoy, Gustavo Rene Piñero, Patricia Koller, Luca Masotti, Mario Di Napoli 
World J Crit Care Med 4(3):213-229. Published online Aug 4, 2015. doi: 10.5492/wjccm.v4.i3.213
22
Iatrogenic pneumothorax related to mechanical ventilation  
Chien-Wei Hsu, Shu-Fen Sun 
World J Crit Care Med 3(1):8-14. Published online Feb 4, 2014. doi: 10.5492/wjccm.v3.i1.8
23
Anticoagulant modulation of inflammation in severe sepsis  
Karen S Allen, Eva Sawheny, Gary T Kinasewitz 
World J Crit Care Med 4(2):105-115. Published online May 4, 2015. doi: 10.5492/wjccm.v4.i2.105
24
Extracorporeal membrane oxygenation for pediatric respiratory failure: History, development and current status  
Anna Maslach-Hubbard, Susan L Bratton 
World J Crit Care Med 2(4):29-39. Published online Nov 4, 2013. doi: 10.5492/wjccm.v2.i4.29
25
Epidemiology of electrical burns and its impact on quality of life - the developing world scenario  
Giriraj Gandhi, Atul Parashar, Ramesh K Sharma 
World J Crit Care Med 11(1):58-69. Published online Jan 9, 2022. doi: 10.5492/wjccm.v11.i1.58
26
Independent lung ventilation: Implementation strategies and review of literature  
Sheri Berg, Edward A Bittner, Lorenzo Berra, Robert M Kacmarek, Abraham Sonny 
World J Crit Care Med 8(4):49-58. Published online Jul 31, 2019. doi: 10.5492/wjccm.v8.i4.49
27
Severe sepsis and septic shock in the elderly: An overview  
Prashant Nasa, Deven Juneja, Omender Singh 
World J Crit Care Med 1(1):23-30. Published online Feb 4, 2012. doi: 10.5492/wjccm.v1.i1.23
28
Early debridement and delayed primary vascularized cover in forearm electrical burns: A prospective study  
Aniruddh Mene, Gautam Biswas, Atul Parashar, Anish Bhattacharya 
World J Crit Care Med 5(4):228-234. Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.228
29
30
Neuroprotective measures in children with traumatic brain injury  
Shruti Agrawal, Ricardo Garcia Branco 
World J Crit Care Med 5(1):36-46. Published online Feb 4, 2016. doi: 10.5492/wjccm.v5.i1.36
31
Vasopressin in vasoplegic shock: A systematic review  
Andrew J Webb, Mohamed O Seisa, Tarek Nayfeh, Patrick M Wieruszewski, Scott D Nei, Nathan J Smischney 
World J Crit Care Med 9(5):88-98. Published online Dec 18, 2020. doi: 10.5492/wjccm.v9.i5.88
32
Adverse events in critical care: Search and active detection through the Trigger Tool  
Juan G Barrientos, Daniel Rodas, Oralia Monroy, Diana C Restrepo, Alejandro Cardona, Paula T Rivera, Francisco J Molina 
World J Crit Care Med 7(1):9-15. Published online Feb 4, 2018. doi: 10.5492/wjccm.v7.i1.9
33
Severe scrub typhus infection: Clinical features, diagnostic challenges and management  
John Victor Peter, Thomas I Sudarsan, John Anthony J Prakash, George M Varghese 
World J Crit Care Med 4(3):244-250. Published online Aug 4, 2015. doi: 10.5492/wjccm.v4.i3.244
34
Characteristics of postintensive care syndrome in survivors of pediatric critical illness: A systematic review  
Elizabeth A Herrup, Beth Wieczorek, Sapna R Kudchadkar 
World J Crit Care Med 6(2):124-134. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.124
35
Critical care management and intensive care unit outcomes following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy  
Sumit Kapoor, Adel Bassily-Marcus, Rafael Alba Yunen, Parissa Tabrizian, Sabrine Semoin, Joseph Blankush, Daniel Labow, John Oropello, Anthony Manasia, Roopa Kohli-Seth 
World J Crit Care Med 6(2):116-123. Published online May 4, 2017. doi: 10.5492/wjccm.v6.i2.116
36
Timing, method and discontinuation of hydrocortisone administration for septic shock patients  
Miguel A Ibarra-Estrada, Quetzalcóatl Chávez-Peña, Claudia I Reynoso-Estrella, Jorge Rios-Zermeño, Pável E Aguilera-González, Miguel A García-Soto, Guadalupe Aguirre-Avalos 
World J Crit Care Med 6(1):65-73. Published online Feb 4, 2017. doi: 10.5492/wjccm.v6.i1.65
37
Experience with hemoadsorption (CytoSorb®) in the management of septic shock patients  
Arun Raizada, Gourav Kochhar, Saurabh Nanda, Aditi Gupta, Joby Varghese George, Ashish Kumar, Chitra Mehta, Yatin Mehta 
World J Crit Care Med 9(1):1-12. Published online Jan 31, 2020. doi: 10.5492/wjccm.v9.i1.1
38
Clonidine use during dexmedetomidine weaning: A systematic review  
Sanu Rajendraprasad, Molly Wheeler, Erin Wieruszewski, Joseph Gottwald, Lindsey A. Wallace, Danielle Gerberi, Patrick M Wieruszewski, Nathan J Smischney 
World J Crit Care Med 12(1):18-28. Published online Jan 9, 2023. doi: 10.5492/wjccm.v12.i1.18
39
Acute cor pulmonale in patients with acute respiratory distress syndrome: A comprehensive review  
Kay Choong See 
World J Crit Care Med 10(2):35-42. Published online Mar 9, 2021. doi: 10.5492/wjccm.v10.i2.35
40
41
Brain-lung crosstalk: Implications for neurocritical care patients  
Ségolène Mrozek, Jean-Michel Constantin, Thomas Geeraerts 
World J Crit Care Med 4(3):163-178. Published online Aug 4, 2015. doi: 10.5492/wjccm.v4.i3.163
42
Clinical characteristics and outcomes associated with nasal intermittent mandatory ventilation in acute pediatric respiratory failure  
Billy C Wang, Theodore Pei, Cheryl B Lin, Rong Guo, David Elashoff, Carol Pineda, James A Lin 
World J Crit Care Med 7(4):46-51. Published online Sep 7, 2018. doi: 10.5492/wjccm.v7.i4.46
43
Controversies in fluid therapy: Type, dose and toxicity  
Robert C McDermid, Karthik Raghunathan, Adam Romanovsky, Andrew D Shaw, Sean M Bagshaw 
World J Crit Care Med 3(1):24-33. Published online Feb 4, 2014. doi: 10.5492/wjccm.v3.i1.24
44
45
Multicentered prospective investigator initiated study to evaluate the clinical outcomes with extracorporeal cytokine adsorption device (CytoSorb®) in patients with sepsis and septic shock  
Prashant Sakhalvalkar, Ma Aleem, Shiva Prasad, Senthil Kumar, Prachee Sathe, Rajib Paul 
World J Crit Care Med 10(1):22-34. Published online Jan 9, 2021. doi: 10.5492/wjccm.v10.i1.22
46
Critical care practice in India: Results of the intensive care unit need assessment survey (ININ2018)  
Rahul Kashyap, Kirtivardhan Vashistha, Chetan Saini, Taru Dutt, Dileep Raman, Vikas Bansal, Harpreet Singh, Geeta Bhandari, Nagarajan Ramakrishnan, Harshit Seth, Divya Sharma, Premkumar Seshadri, Mradul Kumar Daga, Mohan Gurjar, Yash Javeri, Salim Surani, Joseph Varon, ININ-2018 Investigators Team 
World J Crit Care Med 9(2):31-42. Published online Jun 5, 2020. doi: 10.5492/wjccm.v9.i2.31
47
Modeling cardiac arrest and resuscitation in the domestic pig  
Brandon H Cherry, Anh Q Nguyen, Roger A Hollrah, Albert H Olivencia-Yurvati, Robert T Mallet 
World J Crit Care Med 4(1):1-12. Published online Feb 4, 2015. doi: 10.5492/wjccm.v4.i1.1
48
Venous excess ultrasound: A mini-review and practical guide for its application in critically ill patients  
Kay Choong See, Melissa Mei Ing Ngai, Wei Ven Chin 
World J Crit Care Med 14(2):101708. Published online Jun 9, 2025. doi: 10.5492/wjccm.v14.i2.101708
49
Endotracheal intubation sedation in the intensive care unit  
Nathan J Smischney, Pritee Tarwade 
World J Crit Care Med 11(1):33-39. Published online Jan 9, 2022. doi: 10.5492/wjccm.v11.i1.33
50
Determination of functional prognosis in hospitalized patients following an intensive care admission  
Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, George Ntoumenopoulos, Jerffesson Dias, Fernando S Guimaraes 
World J Crit Care Med 5(4):219-227. Published online Nov 4, 2016. doi: 10.5492/wjccm.v5.i4.219
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