Dr. Sezer Saglam is a Distinguished Professor in the School of Medicine, Demiroglu Bilim University, Istanbul/Turkey. Having received his MD degree from Agean Medical University in 1991, Dr. Saglam undertook his postgraduate internal medicine training at the Istanbul University ,Cerrahpasa Medical Faculty Hospital (1996) and has finished medical oncology at Istanbul University Oncology Institue at 2005. What week should be surgery after neoadjuvant therapy in rectal cancers. Istanbul R-01 study as a first author published its randomized study in 2014. Two BRUNCH regimen Phase 2 studies were published in which morning and afternoon administration of Capecitabine increased the effectiveness and reduced the side effects.The study of chronomodusated temozolamide in neuroendocrine tumors continues.