Published online Jun 26, 2019. doi: 10.12998/wjcc.v7.i12.1383
Peer-review started: March 23, 2019
First decision: April 18, 2019
Revised: April 23, 2019
Accepted: May 1, 2019
Article in press: May 1, 2019
Published online: June 26, 2019
Periodontal diseases are associated with various systemic diseases, including cardiovascular diseases such as stroke and atherosclerosis, which seriously affect the quality of life for patients.
At present, little is known about the potential mechanism of surgical treatment for periodontitis.
To explore the mechanism of surgical treatment for periodontitis based on the gene expression of peripheral blood mononuclear cells.
Co-expression analysis, enrichment analysis, crosstalk analysis, and pivot regulatory factor prediction
A total of 337 genes related to periodontitis were clustered into 8 co-expression modules. These genes are mainly involved in G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, and adenylate cyclase-modulating G-protein coupled receptor signaling pathway. In addition, 94 transcription factors (including NFKB1, SP1, and STAT3) and 1198 ncRNAs (including MALAT1, CRNDE, and ANCR) regulatory module genes were identified.
The key factors we have identified affect the recovery of periodontitis after surgery through a variety of biological processes and signaling pathways
The results of this study provide a new theoretical basis and individualized treatment direction for follow-up treatment.