Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 26, 2019; 7(12): 1383-1392
Published online Jun 26, 2019. doi: 10.12998/wjcc.v7.i12.1383
Study on gene expression patterns and functional pathways of peripheral blood monocytes reveals potential molecular mechanism of surgical treatment for periodontitis
Jin-Ji Ma, Hong-Mei Liu, Xiang-Hua Xu, Li-Xin Guo, Qing Lin
Jin-Ji Ma, Jinan Stomatological Hospital Gaoxin Branch, Jinan 250001, Shandong Province, China
Hong-Mei Liu, Li-Xin Guo, Qing Lin, Department of Endodontics, Jinan Stomatological Hospital, Jinan 250001, Shandong Province, China
Xiang-Hua Xu, Department of Stomatology, Shandong Provincial Hospital, Jinan 250001, Shandong Province, China
Author contributions: Ma JJ and Liu HM contributed equally to this work. Ma JJ, Liu HM, and Xu XH designed the research; Ma JJ, Liu HM, and Guo LX performed the research; Xu XH and Lin Q analyzed the data; Ma JJ, Liu HM, and Lin Q wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Jinan Stomatological Hospital.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Qing Lin, BSc, Attending Doctor, Department of Endodontics, Jinan Stomatological Hospital, No. 101, Jingliu Road, Jinan 250001, Shandong Province, China.
Telephone: +86-531-86261570 Fax: +86-531-86261570
Received: March 21, 2019
Peer-review started: March 23, 2019
First decision: April 18, 2019
Revised: April 23, 2019
Accepted: May 1, 2019
Article in press: May 1, 2019
Published online: June 26, 2019
Core Tip

Core tip: Based on the expression pattern and function of genes in peripheral blood mononuclear cells of periodontitis patients, key genes (including EGF, RPS27A, GNB3, etc.) were identified. Further, transcription factors (including NFKB1, SP1, STAT3, etc.,) and non-coding RNAs (including MALAT1, CRNDE, and ANCR) that significantly regulated gene co-expression modules were identified. Exploring the relationships between genes and regulators may reveal the potential molecular mechanism of surgical treatment for periodontitis.