Observational Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 26, 2019; 7(8): 940-950
Published online Apr 26, 2019. doi: 10.12998/wjcc.v7.i8.940
Association between ventricular repolarization variables and cardiac diastolic function: A cross-sectional study of a healthy Chinese population
Zhi-Dan Li, Xiao-Juan Bai, Lu-Lu Han, Wen Han, Xue-Feng Sun, Xiang-Mei Chen
Zhi-Dan Li, Xiao-Juan Bai, Lu-Lu Han, Wen Han, Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Xue-Feng Sun, Xiang-Mei Chen, Department of Kidney, General Hospital of Chinese People’s Liberation Army, Beijing 100853, China
Author contributions: Li ZD analyzed the data and drafted the manuscript; Bai XJ designed the manuscript and approved the manuscript for final submission; Han LL and Han W measured some important parameters; Sun XF and Chen XM participated in the coordination of the study; all authors read and approved the final manuscript.
Supported by the National Basic Research Program of China, No. 973-Program #2007CB507405.
Institutional review board statement: The study was approved by the ethics committee of General Hospital of Chinese People’s Liberation Army (Beijing, China).
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Juan Bai, PhD, Professor, Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. xiaojuan_bai@126.com
Telephone: +86-24-62043437 Fax: +86-24-62043437
Received: December 26, 2018
Peer-review started: December 27, 2018
First decision: March 10, 2019
Revised: March 28, 2019
Accepted: April 9, 2019
Article in press: April 9, 2019
Published online: April 26, 2019
Core Tip

Core tip: A community-based cross-sectional study conducted to assess the relationship between ventricular repolarization variables and cardiac diastolic function in apparently healthy Chinese individuals. We observed an independent association between ventricular repolarization variables and cardiac diastolic function parameters, and moderate levels of the QTc interval tend to have a protective effect on diastolic dysfunction in men. Electromechanical coupling may represent a relationship between heterogeneity of repolarization and abnormal myocardial mechanics.