Published online Apr 26, 2019. doi: 10.12998/wjcc.v7.i8.940
Peer-review started: December 27, 2018
First decision: March 10, 2019
Revised: March 28, 2019
Accepted: April 9, 2019
Article in press: April 9, 2019
Published online: April 26, 2019
Asymptomatic diastolic dysfunction present for a significant period of time before developing into symptomatic heart failure (HF), and diastolic electromechanical coupling may represent a unifier linking diastolic dysfunction, calcium handling, and repolarization abnormalities with the development of symptomatic HF. We assessed the relationship between ventricular repolarization variables, such as the QT interval, Tpe interval and Tpe/QT ratio, and diastolic function in an apparently healthy Chinese population through a community-based cross-sectional study.
Some studies have reported that electrical repolarization abnormalities are associated with declining diastolic function in patients with suspected HF, hypertension, and diabetes mellitus. However, diseases such as hypertension and diabetes mellitus influence both heart structure and heart function and are powerful potential confounders of electromechanical coupling measurements. Therefore, this study hopes to determine whether measuring repolarization variables may provide information valuable for predicting cardiac diastolic function in healthy people.
The research objective of this study was to explore the relationship between ventricular repolarization variables and cardiac diastolic function in apparently healthy Chinese individuals.
We retrospectively analyzed 414 healthy subjects aged 35-91 years who were enrolled between September 2007 and June 2008. All subjects underwent standard 12-lead electrocardiography (ECG) and comprehensive echocardiography. ECG and echocardiography results were analyzed separately and in a blinded fashion. Correlation and regression analyses were applied to determine associations. This study is a community-based cross-sectional study.
Our research found that even in healthy people, ventricular repolarization variables are associated with cardiac diastolic function parameters. Furthermore, moderate levels of the QTc interval tend to have a protective effect on diastolic dysfunction in men.
Repolarization variables are associated with cardiac diastolic function even in healthy people. Electromechanical coupling may represent a relationship between heterogeneity of repolarization and abnormal myocardial mechanics.
We observed an independent association between ventricular repolarization variables and cardiac diastolic function in a community-based cross-sectional study. However, a relatively low number of subjects were included in the study, and the cross-sectional study has its own shortcomings. A longitudinally designed study is required to confirm the current findings.