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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2025; 13(22): 104643
Published online Aug 6, 2025. doi: 10.12998/wjcc.v13.i22.104643
Published online Aug 6, 2025. doi: 10.12998/wjcc.v13.i22.104643
Human papillomavirus associated serous carcinoma of the uterine cervix in a patient with long-term survival: A case report
Hui-Qiong Huang, Lu Yang, Qing-Li Li, Chun-Tang Sun, Feng-Ming Gong, Department of Gynecology and Obstetrics, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Huang HQ contributed to wrote the manuscript; Huang HQ, Yang L, and Li QL contributed to analyzed the data; Gong FM contributed to designed the research study; Sun CT contributed to supervision; All authors have read and approve the final manuscript.
Supported by the Sichuan Science and Technology Program, No. 2022NSFSC0797.
Informed consent statement: Informed consent statement was obtained from the patient.
Conflict-of-interest statement: None of the authors have any conflict of interest and the document was prepared in pdf format.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng-Ming Gong, Department of Gynecology and Obstetrics, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, No. 17 Section 3, Renmin South Road, Wuhou Distrct, Chengdu 610041, Sichuan Province, China.
Received: December 31, 2024
Revised: March 21, 2025
Accepted: April 14, 2025
Published online: August 6, 2025
Processing time: 138 Days and 22 Hours
Revised: March 21, 2025
Accepted: April 14, 2025
Published online: August 6, 2025
Processing time: 138 Days and 22 Hours
Core Tip
Core Tip: A 58-year-old Chinese woman presented with painless vaginal bleeding that appeared as droplets after sexual intercourse. Based on human papillomavirus (HPV) testing and pathology results after radical hysterectomy, the patient was diagnosed with primary advanced HPV-associated primary serous carcinoma of the uterine cervix (USCC). A multimodal treatment approach incorporating surgery, radiotherapy, and chemotherapy was used. The patient showed no evidence of disease progression and achieved a long-term survival of 53 months. USCC is a rare, invasive disease; moreover, comprehensive treatment can prolong patient survival and improve prognosis.