Huang HQ, Yang L, Li QL, Sun CT, Gong FM. Human papillomavirus associated serous carcinoma of the uterine cervix in a patient with long-term survival: A case report. World J Clin Cases 2025; 13(22): 104643 [DOI: 10.12998/wjcc.v13.i22.104643]
Corresponding Author of This Article
Feng-Ming Gong, Department of Gynecology and Obstetrics, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, No. 17 Section 3, Renmin South Road, Wuhou Distrct, Chengdu 610041, Sichuan Province, China. 18180602061@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Human papillomavirus associated serous carcinoma of the uterine cervix in a patient with long-term survival: A case report
Hui-Qiong Huang, Lu Yang, Qing-Li Li, Chun-Tang Sun, Feng-Ming Gong
Hui-Qiong Huang, Lu Yang, Qing-Li Li, Chun-Tang Sun, Feng-Ming Gong, Department of Gynecology and Obstetrics, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Huang HQ contributed to wrote the manuscript; Huang HQ, Yang L, and Li QL contributed to analyzed the data; Gong FM contributed to designed the research study; Sun CT contributed to supervision; All authors have read and approve the final manuscript.
Supported by the Sichuan Science and Technology Program, No. 2022NSFSC0797.
Informed consent statement: Informed consent statement was obtained from the patient.
Conflict-of-interest statement: None of the authors have any conflict of interest and the document was prepared in pdf format.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng-Ming Gong, Department of Gynecology and Obstetrics, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, No. 17 Section 3, Renmin South Road, Wuhou Distrct, Chengdu 610041, Sichuan Province, China. 18180602061@163.com
Received: December 31, 2024 Revised: March 21, 2025 Accepted: April 14, 2025 Published online: August 6, 2025 Processing time: 138 Days and 22 Hours
Abstract
BACKGROUND
Serous carcinoma of the uterine cervix (USCC) represents a rare subtype of cervical adenocarcinoma, classified into human papillomavirus (HPV)-independent and HPV-associated types. It is characterized by high invasiveness and poor prognosis, with limited global reports on this condition.
CASE SUMMARY
A 58-year-old Chinese woman presented with painless vaginal bleeding after sexual intercourse, which appeared as droplets. HPV testing and histopathological analysis confirmed the diagnosis of HPV-associated primary serous carcinoma of the USCC. The patient underwent radical hysterectomy and was diagnosed with primary serous carcinoma of the uterine cervix, stage III C2 (FIGO 2018). A multimodal treatment approach, including surgery, radiotherapy, and chemotherapy, was administered. After additional concurrent chemoradiotherapy and three cycles of chemotherapy, the patient showed no evidence of disease progression and achieved long-term survival for 53 months.
CONCLUSION
USCC is a rare and aggressive malignancy. Upon diagnosis, multimodal treatment strategies, including surgery, radiotherapy, and chemotherapy, can effectively prolong patient survival and improve prognosis.
Core Tip: A 58-year-old Chinese woman presented with painless vaginal bleeding that appeared as droplets after sexual intercourse. Based on human papillomavirus (HPV) testing and pathology results after radical hysterectomy, the patient was diagnosed with primary advanced HPV-associated primary serous carcinoma of the uterine cervix (USCC). A multimodal treatment approach incorporating surgery, radiotherapy, and chemotherapy was used. The patient showed no evidence of disease progression and achieved a long-term survival of 53 months. USCC is a rare, invasive disease; moreover, comprehensive treatment can prolong patient survival and improve prognosis.
