Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2022; 10(19): 6750-6758
Published online Jul 6, 2022. doi: 10.12998/wjcc.v10.i19.6750
Tumor-to-tumor metastasis of clear cell renal cell carcinoma to contralateral synchronous pheochromocytoma: A case report
Hsin-Yu Wen, Jing Hou, Hao Zeng, Qiao Zhou, Ni Chen
Hsin-Yu Wen, Jing Hou, Qiao Zhou, Ni Chen, Department of Pathology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Hao Zeng, Department of Urology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Wen HY analyzed the data and performed the experiments; Zeng H provided clinical data; Hou J and Chen N reviewed the pathologic material and diagnosis; Wen HY prepared the draft of the manuscript; Zhou Q and Chen N designed and supervised the study, wrote and revised the manuscript.
Supported by the National Natural Science Foundation of China, No. NSFC 81872107 and No. NSFC 81872108.
Informed consent statement: This study was approved by the Institutional Review Board of West China Hospital of Sichuan University. Written informed consent was obtained from the patient and her family member.
Conflict-of-interest statement: The authors declare no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Ni Chen, MD, PhD, Doctor, Professor, Department of Pathology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China.
Received: February 28, 2022
Peer-review started: February 28, 2022
First decision: April 8, 2022
Revised: April 19, 2022
Accepted: April 28, 2022
Article in press: April 28, 2022
Published online: July 6, 2022
Core Tip

Core Tip: Tumor-to-tumor metastasis (TTM) is uncommon. Only a limited number of cases in which renal cell carcinoma (RCC) is the donor tumor of TTM have been reported in the literature, and none of these studies have described RCC metastasizing to synchronous pheochromocytoma (PCC). Here, we report a unique case of clear cell renal cell carcinoma (CCRCC) metastasizing to contralateral retroperitoneal/adrenal PCC; molecular characterization by whole genome sequencing, mutational analysis by Sanger sequencing, and fluorescence in situ hybridization analysis for 3p loss were performed. This is the first case of CCRCC metastasizing to PCC.