Published online Oct 6, 2020. doi: 10.12998/wjcc.v8.i19.4370
Peer-review started: April 28, 2020
First decision: May 21, 2020
Revised: June 2, 2020
Accepted: September 8, 2020
Article in press: September 8, 2020
Published online: October 6, 2020
Coronavirus disease 2019 (COVID-19) has been spreading rapidly around the world. The disease progressed extremely fast in some severe to critical patients.
Early identification of COVID-19 patients at high risk is important for improving the clinical practice and outcomes.
To investigate the abnormalities of coagulation parameters in the patients with COVID-19 and their prognostic values.
A retrospective, single-center study included 213 patients. The coagulation parameters at admission were compared between the survivors and those who died. The prognostic values of coagulation disorders were analyzed with logistic regression.
Coagulation disorders were significantly more common in the patients who died with COVID-19 than the survivors. Prothrombin time (PT), concentration of fibrin degradation products, respiration rate and age were predictive factors for fatal outcomes. The fatality of patients with prolonged PT at admission was significantly higher than those with normal PT.
Patients with prolonged PT at admission were faced with a much higher risk of death. Thus, clinicians should be aware of this and treat these patients with caution.
Patients with prolonged prothrombin time at admission should be treated with caution as they faced a much higher risk of death. Coagulation disorders were significantly more common in the patients who died with COVID-19.