Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2020; 8(19): 4370-4379
Published online Oct 6, 2020. doi: 10.12998/wjcc.v8.i19.4370
Prolonged prothrombin time at admission predicts poor clinical outcome in COVID-19 patients
Lang Wang, Wen-Bo He, Xiao-Mei Yu, Da-Long Hu, Hong Jiang
Lang Wang, Wen-Bo He, Xiao-Mei Yu, Hong Jiang, Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Lang Wang, Wen-Bo He, Xiao-Mei Yu, Hong Jiang, Cardiovascular Research Institute, Wuhan University, Wuhan 430060, Hubei Province, China
Lang Wang, Wen-Bo He, Xiao-Mei Yu, Hong Jiang, Hubei Key Laboratory of Cardiology, Wuhan 430060, Hubei Province, China
Da-Long Hu, School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, Australia
Author contributions: Wang L and He WB drafted the manuscript; Jiang H and Wang L conceived the idea; Wang L, He WB and Yu XM reviewed the medical records and collected the data; Hu DL performed the statistical analysis and reviewed the manuscript; Jiang H reviewed the manuscript; All authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81570450 and No. 81900455.
Institutional review board statement: This study was reviewed and approved by the National Natural Science Foundation of China.
Informed consent statement: The National Natural Science Foundation of China waived the informed consent for this study.
Conflict-of-interest statement: There is no conflict of interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hong Jiang, MD, Chief Physician, Director, Full Professor, Department of Cardiology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, District of Wuchang, Wuhan 430060, Hubei Province, China. hong-jiang@whu.edu.cn
Received: April 28, 2020
Peer-review started: April 28, 2020
First decision: May 21, 2020
Revised: June 2, 2020
Accepted: September 8, 2020
Article in press: September 8, 2020
Published online: October 6, 2020
Core Tip

Core Tip: Coagulation disorders were significantly more common in the patients who died with coronavirus disease 2019 than the survivors. Prothrombin time (PT), concentration of fibrin degradation products, respiration rate and age were predictive factors for fatal outcome. The fatality of patients with prolonged PT at admission was significantly higher than those with normal PT. Patients with prolonged PT at admission should be paid more attention to and treated with caution.