Synchronous early gastric and intestinal mucosa-associated lymphoid tissue lymphoma in a Helicobacter pylori-negative patient: A case report

Figure 1 Endoscopic images of the gastric lesion. A: A solitary submucosal eminence was observed; B: Narrow-band imaging appearance of gastric pit pattern elongates and expands, with appearance of irregular abnormal vessels; C: Endoscopic ultrasonography showed thickening of muscularis mucosa with a hypoechoic lesion 2 mm × 5 mm in size.

Figure 2 Immunohistochemical results of the gastric mucosa-associated lymphoid tissue lymphoma. A: Hematoxylin-eosin staining of extensive lymphocytic infiltration (200×); B: Immunohistochemistry showed that the lymphoid cells were diffusely positive for CD20 (400×); C: CD21 showed expansion and destruction of follicular dendritic cells (400×); D: Immunohistochemical stains showed CD3 negative (100×); E: CD10 was negative (100×); F: Bcl-6 was negative (100×).

Figure 3 Gene detection revealed clonal rearrangement of the IgH gene in B cells.

Figure 4 Endoscopic images and immunohistochemical results of colon mucosa-associated lymphoid tissue lymphoma. A: Endoscopic images showing a single 5mm polypoid lesion; B: Hematoxylin-eosin staining of lymphocytic infiltration (200×); C: Immunohistochemistry showed that the lymphoid cells were diffusely positive for B cell marker CD20 (400×); D: CD21 showed expansion and destruction of follicular dendritic cells (400×); E: Immunohistochemical stains showed Bcl-2 negative (100×).