Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 16, 2021; 9(11): 2679-2687
Published online Apr 16, 2021. doi: 10.12998/wjcc.v9.i11.2679
Contrast-enhanced ultrasound using SonoVue mixed with oral gastrointestinal contrast agent to evaluate esophageal hiatal hernia: Report of three cases and a literature review
Jing-Yu Wang, Yan Luo, Wen-Ying Wang, Shi-Cheng Zheng, Lian He, Chun-Yan Xie, Li Peng
Jing-Yu Wang, Wen-Ying Wang, Lian He, Li Peng, Department of Ultrasound, First People's Hospital of Longquanyi District, Longquan Hospital of West China Hospital of Sichuan University, Chengdu 610100, Sichuan Province, China
Yan Luo, Department of Ultrasound, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Shi-Cheng Zheng, Chun-Yan Xie, Department of Gastroenterology, First People's Hospital of Longquanyi District, Longquan Hospital of West China Hospital of Sichuan University, Chengdu 610100, Sichuan Province, China
Author contributions: Wang JY, Peng L, and Luo Y designed the study and wrote the manuscript; Wang WY performed the literature search and edited the manuscript; He L collected the data; Zheng SC and Xie CY performed the data analysis and interpretation; all authors approved the final version of the submitted manuscript and agree to ensure that any questions related to the work are appropriately resolved.
Supported by The Research Project of Sichuan Medical Association, Nos. S19080 and S18075.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no financial relationships to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li Peng, MD, Associate Chief Physician, Department of Ultrasound, First People's Hospital of Longquanyi District, Longquan Hospital of West China Hospital of Sichuan University, Longquanyi District, Chengdu 610100, Sichuan Province, China. 912435936@qq.com
Received: December 16, 2020
Peer-review started: December 16, 2020
First decision: January 10, 2021
Revised: January 20, 2021
Accepted: February 8, 2021
Article in press: February 8, 2021
Published online: April 16, 2021
Core Tip

Core Tip: In this research, we used a new contrast ultrasound examination method to evaluate esophageal hiatal hernia (EHH). An oral agent mixture was created by mixing microbubble-based SonoVue with a gastrointestinal contrast agent, and applied in contrast ultrasound for evaluation of EHH. This new examination method not only allowed for clear image direct visualization but also dynamic observation of esophageal reflux. To our best knowledge, this is the first report on the use of SonoVue mixed with an oral gastrointestinal contrast agent in the diagnosis of EHH.