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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2020; 8(19): 4595-4602
Published online Oct 6, 2020. doi: 10.12998/wjcc.v8.i19.4595
Published online Oct 6, 2020. doi: 10.12998/wjcc.v8.i19.4595
Severe hyperlipemia-induced pseudoerythrocytosis - Implication for misdiagnosis and blood transfusion: A case report and literature review
Xi-Chen Zhao, Bo Ju, Na Wei, Department of Hematology, The Central Hospital of Qingdao West Coast New Area, Qingdao 266555, Shandong Province, China
Jian Ding, Department of Clinical Laboratory, The Central Hospital of Qingdao West Coast New Area, Qingdao 266555, Shandong Province, China
Fan-Jun Meng, Hong-Guo Zhao, Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong Province, China
Author contributions: Zhao XC designed the study and drafted the manuscript; Zhao XC, Ju B, and Wei N participated in the treatment of this patient; Ding J performed the laboratory tests; Meng FJ and Zhao HG supervised the treatment and revised the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publishing this report and any accompanying laboratory data.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hong-Guo Zhao, MD, Chief Doctor, Professor, Department of Hematology, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, Shandong Province, China. zhaohongguo6201@163.com
Received: May 8, 2020
Peer-review started: May 8, 2020
First decision: July 25, 2020
Revised: July 30, 2020
Accepted: August 29, 2020
Article in press: August 29, 2020
Published online: October 6, 2020
Peer-review started: May 8, 2020
First decision: July 25, 2020
Revised: July 30, 2020
Accepted: August 29, 2020
Article in press: August 29, 2020
Published online: October 6, 2020
Core Tip
Core Tip: Severe hyperlipemia could affect the results of complete blood cell examination by automated blood cell counter. Here, we report a patient with severe hyperlipemia who was at first misdiagnosed as a myeloproliferative neoplasm because of the marked abnormalities in complete blood cell examination. Repeated laboratory tests, by measuring dual blood samples that the chylomicron layer was removed in one sample and was not in another, confirmed that the marked abnormalities was caused by the mistaken readings on automated blood cell counter. This phenomenon may lead to the misjudgment of many laboratory tests and the misinterpretation of blood transfusion indications.