Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2019; 7(23): 4075-4083
Published online Dec 6, 2019. doi: 10.12998/wjcc.v7.i23.4075
Diffuse large B cell lymphoma with bilateral adrenal and hypothalamic involvement: A case report and literature review
Ping An, Kang Chen, Guo-Qing Yang, Jing-Tao Dou, Yu-Long Chen, Xin-Ye Jin, Xian-Ling Wang, Yi-Ming Mu, Quan-Shun Wang
Ping An, Kang Chen, Guo-Qing Yang, Jing-Tao Dou, Yu-Long Chen, Xin-Ye Jin, Xian-Ling Wang, Yi-Ming Mu, Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China
Quan-Shun Wang, Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Chen K made substantial contributions to conception and design of the case report; An P analyzed the data and drafted the manuscript; Chen YL and Jin XY made substantial contributions to acquisition of data; Yang GQ, Dou JT, and Wang QS made critical revisions related to important intellectual content of the manuscript; Wang XL made substantial contributions to interpretation of data; Mu YM provided advice for this report; and all authors have approved the final version to be published.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Kang Chen, MD, PhD, Assistant Professor, Department of Endocrinology, Chinese People’s Liberation Army General Hospital, 28 Fuxing Road, Beijing 100853, China. cycon_ck@yeah.net
Telephone: +86-18801217670 Fax: +86-10-66937711
Received: September 7, 2019
Peer-review started: September 7, 2019
First decision: September 23, 2019
Revised: October 22, 2019
Accepted: November 14, 2019
Article in press: November 14, 2019
Published online: December 6, 2019
Core Tip

Core tip: The synchronous involvement of two endocrine organs is rare in Non-Hodgkin’s lymphoma (NHL). This is the first case of NHL with bilateral adrenal gland and hypothalamic involvement that caused adrenocortical insufficiency and panhypopituitarism. The presentation created a diagnostic dilemma, which was resolved by determination of various endocrine hormone levels, biopsy, and 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography. This article aims to discuss the treatment approaches available when a patient with NHL has multiple endocrine organs involved. This report can help physicians avoid misdiagnosis of this disease.