Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 26, 2019; 7(12): 1444-1455
Published online Jun 26, 2019. doi: 10.12998/wjcc.v7.i12.1444
Relationship between circulating irisin levels and overweight/obesity: A meta-analysis
Jue Jia, Fan Yu, Wei-Ping Wei, Ping Yang, Ren Zhang, Yue Sheng, Yong-Qin Shi
Jue Jia, Fan Yu, Wei-Ping Wei, Ping Yang, Yue Sheng, Yong-Qin Shi, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
Ren Zhang, Department of Library of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
Author contributions: Jia J conceived and designed the study; Jia J, Yu F, and Zhang R searched the related articles; Yang P, Wei WP, Sheng Y, and Shi YQ analyzed the data; Jia J and Yu F wrote the manuscript; all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81500351; the Youth Medical Talent Project of Jiangsu Province, No. QNRC2016842; the Jiangsu University Affiliated Hospital "; 5123"; Talent Plan, No. 51232017305; and the 169 Talent Project of Zhenjiang.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jue Jia, MD, Lecturer, Associate Chief Physician, Affiliated Hospital of Jiangsu University, No. 438, Jiefang North Road, Jingkou District, Zhenjiang 212001, Jiangsu Province, China.
Telephone: +86-511-85031120 Fax: +86-511-85019237
Received: February 25, 2019
Peer-review started: February 26, 2019
First decision: April 18, 2019
Revised: April 27, 2019
Accepted: May 2, 2019
Article in press: May 2, 2019
Published online: June 26, 2019
Core Tip

Core tip: This study is the first meta-analysis that systematically assessed circulating irisin in overweight/obese people. This meta-analysis showed that circulating irisin levels were higher in obese individuals than in healthy controls. It also suggested that circulating irisin levels were higher in obese people in Africa than in controls. This meta-analysis further suggested that obese children exhibited a higher irisin level than controls.