Published online Jun 26, 2019. doi: 10.12998/wjcc.v7.i12.1444
Peer-review started: February 26, 2019
First decision: April 18, 2019
Revised: April 27, 2019
Accepted: May 2, 2019
Article in press: May 2, 2019
Published online: June 26, 2019
Overweight/obesity has been a global health challenge and irisin as a novel myokine is reported to play an important role in the development of metabolism dysfunction and obesity, however, the exact relationship between irisin and overweight/obesity remains unclear.
Many studies on the results of circulating irisin levels in overweight/obesity people are incon-sistent, which has puzzled us in confirming the role of irisin in overweight/obesity, thus, it is necessary to do such an analysis to clarify the relationship between them.
The main objective was to extract available data from studies and clarify the relationship between irisin and overweight/obesity.
We searched Cochrane Library, MEDLINE, SCOPUS, and the ISI Web of Science to retrieve all of the studies associated with circulating irisin levels and overweight/obesity. We estimated standard mean difference values and 95% confidence intervals and used meta-analysis methodology to get final results.
A total of 18 studies were included in this meta-analysis containing 1005 cases and 1242 controls. The overall analysis showed that the circulating irisin level in overweight/obese people was higher than that in overall healthy controls. In the subgroup analysis by ethnicity, the irisin level was higher in overweight/obese people than that in controls in Africa. In addition, in a subgroup analysis by age, the results showed that obese children exhibited a higher irisin level than controls. Studies of larger population samples are needed to better explore the relationship between irisin and overweight/obesity.
This study integrated the existing data to show that the circulating irisin levels in over-weight/obese people was higher than those in healthy controls overall, and explored the potential of irisin as a predictive factor for overweight/obesity.
More studies on the effects of exercise, lifestyle, and weight loss on the irisin level and related prospective studies are needed.