Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2025; 13(29): 108411
Published online Oct 16, 2025. doi: 10.12998/wjcc.v13.i29.108411
Low salivary uric acid levels and periodontitis: New insights and implications for clinical practice
Zhuo-Qun Hu, Yong Wang
Zhuo-Qun Hu, Department of Stomatology, Yanbian University Hospital, Yanji 133000, Jilin Province, China
Yong Wang, Department of Internal Medicine, Yanbian University Hospital, Yanji 133000, Jilin Province, China
Author contributions: Wang Y contributed to conception and design; Hu ZQ contributed to literature search and writing; All of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong Wang, Researcher, Yanbian University Hospital, No. 1327 Ju Zi Road, Yanji 133000, Jilin Province, China. wangyong0327ybu@163.com
Received: April 14, 2025
Revised: May 23, 2025
Accepted: July 22, 2025
Published online: October 16, 2025
Processing time: 136 Days and 20.4 Hours
Core Tip

Core Tip: This letter explores the relationship between low salivary uric acid levels and periodontitis, revealing a significant independent association and inverse correlation with disease severity. Salivary uric acid emerges as a potential biomarker for disease progression, offering new insights into the pathophysiology of periodontitis and paving the way for innovative diagnostic and therapeutic strategies in clinical practice.