Zhong XY, Liang ZJ, Lan ML, Xu XG, Yuan L, Zeng JX. Acinar cystic transformation of the pancreas: A rare case report. World J Clin Cases 2025; 13(23): 107096 [DOI: 10.12998/wjcc.v13.i23.107096]
Corresponding Author of This Article
Ji-Xiao Zeng, MD, PhD, Professor, Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, No. 318 Renmin Road, Guangzhou 510623, Guangdong Province, China. zengjixiao@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xiao-Ying Zhong, Guangzhou Medical University, Guangzhou 510623, Guangdong Province, China
Zi-Jian Liang, Meng-Long Lan, Xiao-Gang Xu, Ji-Xiao Zeng, Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong Province, China
Li Yuan, Department of Pathology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong Province, China
Author contributions: Zhong XY and Liang ZJ contributed to manuscript writing and data collection; Lan ML, Xu XG contributed to manuscript editing; Zeng JX contributed to conceptualization and supervision; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ji-Xiao Zeng, MD, PhD, Professor, Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, No. 318 Renmin Road, Guangzhou 510623, Guangdong Province, China. zengjixiao@163.com
Received: March 16, 2025 Revised: April 5, 2025 Accepted: May 8, 2025 Published online: August 16, 2025 Processing time: 81 Days and 4.6 Hours
Core Tip
Core Tip: Acinar cystic transformation (ACT) of the pancreas is a rare non-neoplastic transformation of the pancreas, more rarely seen in children. Diagnosis is based on histological findings and therapy should be individualized. We report a rare case of a female child undergoing tumor reduction surgery. ACT is a heterogeneous entity, including a wide spectrum of lesions with different potential etiopathogenetic aspects. Because the clinical course is almost invariably benign, upfront surgical resection is not supported for asymptomatic lesions. We conclude that, because ACT is a slow-growing benign tumor, the principle of treatment is to follow up the child closely rather than perform overly aggressive surgery when imaging and cytological results are mutually supportive.
