Systematic Reviews
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2025; 13(23): 105762
Published online Aug 16, 2025. doi: 10.12998/wjcc.v13.i23.105762
Evidence for the association between psychological stress and peri-implant health among middle-aged and elderly adults: A systemic review
Yen-Lan Chang, Gen-Min Lin, Shih-Ying Lin, Ren-Yeong Huang, Po-Jan Kuo, Nancy Nei-Shiuh Chang, Kun-Zhe Tsai
Yen-Lan Chang, Department of Stomatology, Mackay Memorial Hospital, Taipei 104217, Taiwan
Gen-Min Lin, Kun-Zhe Tsai, Department of Medicine, Hualien Armed Forces General Hospital, Hualien 970, Taiwan
Gen-Min Lin, Department of Medicine, Tri-Service General Hospital and National Defense Medical Center, Taipei 104, Taiwan
Shih-Ying Lin, Department of Stomatology, MacKay Memorial Hospital, Taipei 104217, Taiwan
Ren-Yeong Huang, Nancy Nei-Shiuh Chang, Kun-Zhe Tsai, Department of Periodontology and School of Dentistry, Tri-Service General Hospital and National Defense Medical Center, Taipei 104, Taiwan
Po-Jan Kuo, School of Dentistry, Department of Periodontology, National Defense Medical Center and Tri-Service General Hospital, Taipei 104, Taiwan
Po-Jan Kuo, Nancy Nei-Shiuh Chang, Department of Periodontology, Lin’s Orthodontic Clinic, Taipei 104, Taiwan
Kun-Zhe Tsai, Department of Stomatology of Periodontology, Mackay Memorial Hospital, Taipei 104217, Taiwan
Author contributions: The study design was conceptualized and developed by Tsai KZ; Data collection, project administration, and data curation were carried out by Chang YL and Lin SY; Formal data analysis was conducted by Tsai KZ and Lin GM; Yen-Lan Chang prepared the initial draft of the manuscript, while Kuo PJ, Chang NNS, and Huang RY critically reviewed and provided editorial revisions; Lin GM assisted with the final English proofreading and editing of the article; All authors contributed to the final manuscript and approved its submission.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kun-Zhe Tsai, DDS, Department of Stomatology of Periodontology, Mackay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Zhongshan District, Taipei 104217, Taiwan. stupidgrandpa@yahoo.com.tw
Received: February 6, 2025
Revised: April 9, 2025
Accepted: May 7, 2025
Published online: August 16, 2025
Processing time: 118 Days and 3.2 Hours
Core Tip

Core Tip: The bidirectional oral-brain axis has been recently proposed. Numerous contemporary studies have highlighted the association between psychological distress and periodontitis. However, the relationship between psychological distress and peri-implantitis remains unclear. Although the current evidence is limited, all human studies to date suggest that psychological distress increases the risk of peri-implantitis, similar to its impact on periodontitis.