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World J Clin Cases. Aug 16, 2022; 10(23): 8076-8087
Published online Aug 16, 2022. doi: 10.12998/wjcc.v10.i23.8076
Gut microbiota and COVID-19: An intriguing pediatric perspective
Maria Sole Valentino, Claudia Esposito, Simone Colosimo, Angela Maria Caprio, Simona Puzone, Stefano Guarino, Pierluigi Marzuillo, Emanuele Miraglia del Giudice, Anna Di Sessa
Maria Sole Valentino, Claudia Esposito, Simone Colosimo, Angela Maria Caprio, Simona Puzone, Stefano Guarino, Pierluigi Marzuillo, Emanuele Miraglia del Giudice, Anna Di Sessa, Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80138, Italy
Author contributions: Valentino MS wrote the first draft of the manuscript; Miraglia del Giudice E, Di Sessa A and Marzuillo P conceived the manuscript; Di Sessa A and Miraglia del Giudice E supervised the manuscript drafting; Esposito C, Colosimo S, Guarino S, Caprio AM Puzone S reviewed the literature data; Valentino MS and Esposito C prepared the tables; All authors contributed important intellectual content during manuscript drafting or revision.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Anna Di Sessa, MD, PhD, Research Fellow, Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Via de Crecchio 2, Naples 80138, Italy. anna.disessa@libero.it
Received: March 20, 2022
Peer-review started: March 20, 2022
First decision: May 29, 2022
Revised: June 14, 2022
Accepted: July 11, 2022
Article in press: July 11, 202
Published online: August 16, 2022
Core Tip

Core Tip: Growing evidence has shown that severe acute respiratory syndrome coronavirus 2 exerted a role upon the respiratory system. Due to the release of inflammatory cytokines, it might play a "pleiotropic" effect by modulating also the course of several diseases. In particular, recent adult data supported a bidirectional relationship between gut microbiota changes and coronavirus disease 2019 infection. However, similar evidence in the childhood population is less defined. We aimed to provide a comprehensive pediatric overview in this intriguing field.