Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2022; 10(16): 5217-5229
Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5217
Protective effects of female reproductive factors on gastric signet-ring cell carcinoma
Yang Li, Yu-Xin Zhong, Quan Xu, Yan-Tao Tian
Yang Li, Yu-Xin Zhong, Quan Xu, Yan-Tao Tian, Department of Pancreatic and Gastric Surgery, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: All of the authors contributed to this work; Li Y and Tian YT designed the research study and performed the research; Li Y collected the data, performed the statistical analysis, and drafted the manuscript; Li Y, Zhong YX, Xu Q, and Tian YT participated in discussion and manuscript revision; All authors have read and approve the final version of the manuscript and agreed to be accountable for all aspects of the work.
Supported by National Natural Science Foundation of China, No. 82072734.
Institutional review board statement: Ethical approval was obtained through the Chinese Academy of Medical Science (Beijing, China).
Informed consent statement: All participants gave written informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: All data included in this study are available on reasonable request from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Tao Tian, MD, Chief Doctor, Department of Pancreatic and Gastric Surgery, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 South Panjiayuan Lane, Suite 806, Surgical Building, Chaoyang District, Beijing 100021, China. tianyantao@cicams.ac.cn
Received: September 14, 2021
Peer-review started: September 14, 2021
First decision: October 18, 2021
Revised: October 21, 2021
Accepted: April 9, 2022
Article in press: April 9, 2022
Published online: June 6, 2022
Core Tip

Core Tip: The overall incidence of gastric cancer is higher in men than in women worldwide. However, gastric signet-ring cell carcinoma (GSRC) is more frequently observed in younger female patients. Only a few studies have focused on sex-specific differences in GSRC. This study proposed clinicopathological differences between sexes to reveal sex disparities in GSRC and confirmed that female reproductive factors provided protective effects, and the mortality risk of menstrual female patients was lower. Investigation of the mechanism of action of female reproductive factors may provide new insight into the treatment of GSRC.