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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Impact of cytomegalovirus infection on biliary disease after liver transplantation - maybe an essential factor
Jing-Yi Liu, Jian-Rui Zhang, Li-Ying Sun, Zhi-Jun Zhu, Lin Wei, Wei Qu, Zhi-Gui Zeng, Ying Liu, Xin-Yan Zhao
Jing-Yi Liu, Jian-Rui Zhang, Li-Ying Sun, Zhi-Jun Zhu, Lin Wei, Wei Qu, Zhi-Gui Zeng, Ying Liu, Xin-Yan Zhao, Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Jing-Yi Liu, Jian-Rui Zhang, Li-Ying Sun, Zhi-Jun Zhu, Lin Wei, Wei Qu, Zhi-Gui Zeng, Ying Liu, Clinical Center for Pediatric Liver Transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Jing-Yi Liu, Jian-Rui Zhang, Li-Ying Sun, Zhi-Jun Zhu, Lin Wei, Wei Qu, Zhi-Gui Zeng, Ying Liu, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Li-Ying Sun, Intensive Care Unit, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Author contributions: Sun LY, Zhang JR, and Liu JY participated in the research design; Zhang JR and Liu JY participated in sample collection, data analysis, and manuscript writing and contributed equally to this work; Zhu ZJ, Wei L, Qu W, Liu Y, Zeng ZG, and Zhao XY participated in performing the research; All authors have read and approve the final manuscript.
Supported by The National Natural Science Foundation of China, No. 81570586.
Institutional review board statement: The study was reviewed and approved by the Capital Medical University affiliated Beijing Friendship Hospital Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Li-Ying Sun, MD, PhD, Chief Doctor, Professor, Liver Transplantation Center, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Beijing 100050, China. sunxlx@outlook.com
Received: May 13, 2021
Peer-review started: May 13, 2021
First decision: July 4, 2021
Revised: July 17, 2021
Accepted: September 14, 2021
Article in press: September 14, 2021
Published online: December 16, 2021
ARTICLE HIGHLIGHTS
Research background
The association of cytomegalovirus (CMV) with biliary complications after liver transplant (LT) is an essential topic in clinical practice.
Research motivation
In clinical work, we have found that CMV-DNA in the bile and blood was inconsistent in patients with biliary complications after LT, and the positive rate of CMV-DNA in bile was higher than that in the blood.
Research objectives
To investigate the impact of CMV infection on biliary disease.
Research methods
We conducted a retrospective analysis of the clinical data from 57 patients with or without biliary complications.
Research results
CMV detection in bile is more sensitive than in blood. RNAscope in situ hybridization is more sensitive than traditional methods to detect CMV infection in liver tissue. Biliary CMV infection is definitively associated with biliary complications and poor prognosis after LT, especially anastomotic stenosis.
Research conclusions
Patients with negative CMV-DNA in blood should still be monitored for bile CMV-DNA. Bile CMV infection maybe a contributing etiological factor in the development of graft failure.
Research perspectives
Current prevention strategies for CMV infection are inadequate and clinical doctors should be more vigilant of biliary CMV infection.
