Published online Feb 6, 2023. doi: 10.12998/wjcc.v11.i4.830
Peer-review started: October 1, 2022
First decision: November 26, 2022
Revised: December 15, 2022
Accepted: January 9, 2023
Article in press: January 29, 2023
Published online: February 6, 2023
In the perioperative period of biliary surgery, various factors can induce the release of a large number of inflammatory factors, leading to an imbalance in pro-inflammatory and anti-inflammatory responses and resulting in gastrointestinal (GI) dysfunction. It is crucial to reduce the inflammatory response and promote the recovery of GI function after biliary surgery, both of which are the basis and key for perioperative care and postoperative recovery.
Since lack of effective measures to reduce inflammatory response and promote the recovery of GI function after biliary surgery; therefore, it is necessary to develop novel interventions to reduce the stress response and accelerate postoperative recovery.
To better understand the effects of Modified Xiao-Cheng-Qi decoction (MXD) on the inflammatory response and GI function in perioperative of cholelithiasis, also their correlation, we conducted this study.
This was a prospective randomized placebo-controlled trial, in which 162 patients who received biliary tract surgery, were randomly assigned to three groups: MXD group, XD group, and placebo-control group. The parameters included frequency of bowel sounds, time of first flatus and defecation, time of diet, and amount of activity after surgery. The serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), IL-10, serum amyloid A (SAA) protein, and substance P were measured.
Compared to the placebo-control, improvements in GI function were observed in the MXD groups, such as reduced incidence of nausea, vomiting, and bloating, and the earlier first exhaust time, first defecation time, and feeding time after surgery (P < 0.05). On the 1st and 2nd d after surgery, serum levels of IL-6, CRP, and SAA in MXD group were lower than that in placebo control, but substance P level was higher, compared to the control (P < 0.05).
Treatment with MXD can relieve inflammatory response and improve GI function after surgery. Moreover, there are significant correlations between them.
The future research project will focus on the mechanism of MXD to reduce inflammatory reaction and improve GI function.