Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2022; 10(17): 5586-5594
Published online Jun 16, 2022. doi: 10.12998/wjcc.v10.i17.5586
Three-dimensional arterial spin labeling and diffusion kurtosis imaging in evaluating perfusion and infarct area size in acute cerebral ischemia
Yan-Yan Jiang, Zhi-Lin Zhong, Min Zuo
Yan-Yan Jiang, Department of Magnetic Resonance, Wuhan Asia General Hospital, Wuhan 430056, Hubei Province, China
Zhi-Lin Zhong, Department of Radiology, Wuhan Yaxin General Hospital, Wuhan 430056, Hubei Province, China
Min Zuo, Department of Radiology, Wuhan Hanyang Hospital, Wuhan University of Science and Technology, Wuhan 430050, Hubei Province, China
Author contributions: Jiang YY and Zhong ZL contributed equally to this study, and should be regarded as co-first authors, Jiang YY and Zhong ZL designed the study and collected the data; Zuo M drafted the manuscript, Zuo M and Jiang YY analyzed and interpreted data.
Institutional review board statement: This study was approved by the Wuhan Yaxin General Hospital Ethics Committee.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Min Zuo, BM BCh, Associate Chief Physician, Department of Radiology, Wuhan Hanyang Hospital, Wuhan University of Science and Technology, No. 53 Moohu Road, Anyang District, Wuhan 430050, Hubei Province, China. ypzm0518@163.com
Received: January 6, 2022
Peer-review started: January 6, 2022
First decision: February 14, 2022
Revised: March 1, 2022
Accepted: April 9, 2022
Article in press: April 9, 2022
Published online: June 16, 2022
ARTICLE HIGHLIGHTS
Research background

Early thrombolytic therapy is crucial to treat acute cerebral infarction, especially since the onset of thrombolytic therapy takes 1–6 h. Therefore, early diagnosis and evaluation of cerebral infarction is important.

Research motivation

This study explored the methods for assessing perfusion and infarct size in patients with acute cerebral ischemia.

Research objectives

The study aimed to investigate the diagnostic value of magnetic resonance multi-delay three-dimensional arterial spin labeling (3DASL) and diffusion kurtosis imaging (DKI) in evaluating the perfusion and infarct area size in acute cerebral ischemia patients.

Research methods

Eighty-four patients who experienced acute cerebral ischemia from March 2019 to February 2021 were included.

Research results

The apparent diffusion coefficient, average diffusion coefficient (MD), axial diffusion, and radial diffusion values in the lesion area were significantly lower than those in the control area. The average kurtosis (MK), radial kurtosis, and axial kurtosis values in the lesion area were significantly higher than those in the control area. parameters post-labeling delays (PLD) 1.5s and PLD2.5s perfusion parameters in the central, peripheral, and control areas of the infarct lesions in MK/MD-matched and -unmatched patients were not significantly different. PLD1.5s and PLD2.5s perfusion parameter values in the central area of the infarct lesions in MK/MD-matched and -unmatched patients were significantly lower than those in peripheral and control areas. There were no significant differences in the cerebral infarction lesion areas measured using the three methods.

Research conclusions

DKI parameters showed significant difference between the focal and control areas in patients with acute ischemic cerebral infarction. 3DASL can effectively determine the changes in perfusion levels in the lesion area. There was a high correlation between the area of the infarct lesions diagnosed by DKI and T2-weighted imaging.

Research perspectives

3DASL and DKI have broader application value in assessing perfusion and infarct size in patients with acute cerebral ischemia.