Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9982
Peer-review started: June 25, 2021
First decision: August 18, 2021
Revised: August 31, 2021
Accepted: September 15, 2021
Article in press: September 15, 2021
Published online: November 16, 2021
Both squamous cell carcinoma (SCC) and papillary thyroid carcinoma (PTC) are common malignant tumors in the neck. However, seldom has SCC of the thyroid been diagnosed. Further, cytological features of SCC and PTC have rarely been reported. The significance of fine-needle aspiration cytology (FNAC) in the diagnosis of neck masses has been established. Herein, we present an exceedingly rare case of an intrathyroidal SCC diagnosed using FNAC, along with its cytological features.
A 66-year-old man presented with a left-sided neck mass. Ultrasound examination showed an ill-defined nodule. The appearance was hypoechoic with a few hyperechoic spots. FNAC of the left thyroid nodule was performed. A cellular smear was obtained, and it showed a large number of neoplastic cells with rich cytoplasm and poor cell adhesion. Tumor cell nuclei showed coarse nuclear chromatin and a few enlarged prominent nucleoli. An increased nuclear/cytoplasm ratio was observed. Thus, malignancy was diagnosed without a confirmed tumor type. Percutaneous tumor biopsy was performed to make a definite diagnosis. The tumor cells showed typical squamous cell characteristics.
Head and neck SCC and PTC have different cytologies. Measures are needed to ensure accurate diagnosis using FNAC.
Core Tip: Measures such as cell block, immunohistochemical analysis, and genetic testing should be considered to improve the accuracy of diagnosis using fine-needle aspiration.