Published online Sep 6, 2019. doi: 10.12998/wjcc.v7.i17.2427
Peer-review started: March 28, 2019
First decision: August 1, 2019
Revised: August 15, 2019
Accepted: August 25, 2019
Article in press: August 26, 2019
Published online: September 6, 2019
Reduced level of physical activity, high-fat diet and skeletal muscle atrophy are key factors that are likely to contribute to deleterious changes in body composition and metabolic following spinal cord injury (SCI). Reduced caloric intake with lowering percentage macronutrients of fat and increasing protein intake may likely to improve body composition parameters and decrease ectopic adiposity after SCI.
To highlight the effects of dietary manipulation and testosterone replacement therapy (TRT) on body composition after SCI
A 31-year-old male with T5 SCI was administered transdermal TRT daily for 16 wk. Caloric intake and percentage macronutrients were analyzed using dietary recalls. Magnetic resonance imaging and dual-energy x-ray absorptiometry were used to measure changes in body composition.
Caloric intake and fat percentage were reduced by 445 kcal/d and 6.5%, respectively. Total body weight decreased by 8%, body fat decreased by 29%, and lean mass increased by 7%. Thigh subcutaneous adipose tissue cross-sectional area was reduced by 31%.
Manipulation of caloric intake, fat percentage, and protein percentage may have influenced body composition after SCI.
Core tip: Reduction in caloric intake with low-fat and high-protein diet may appear as a reasonable strategy to effectively lose weight and fat mass in persons with spinal cord injury. The supplement of testosterone replacement therapy (TRT) may offset for potential loss in lean mass and reduction in basal metabolic rate that is commonly observed in weight loss program. The combination of dietary manipulation and TRT is a feasible approach and does not appear to be accompanied with any side effects.