Li XL, Ma ZG, Huang WH, Chai EQ, Hao YF. Successful treatment of pyoderma gangrenosum with concomitant immunoglobulin A nephropathy: A case report and review of literature. World J Clin Cases 2018; 6(13): 703-706 [PMID: 30430129 DOI: 10.12998/wjcc.v6.i13.703]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xiao-Li Li, Zhi-Gang Ma, Wen-Hui Huang, Department of Nephrology, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China
Er-Qing Chai, Yun-Fei Hao, Cerebrovascular Disease Center, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China
Author contributions: Hao YF and Ma ZG designed the study. Li XL and Huang WH collected the patient’s clinical data. Chai EQ analyzed the data and wrote the paper.
Informed consent statement: The patient involved in this study gave her written informed consent authorizing the use and disclosure of her protected health information.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yun-Fei Hao, MD, Attending Doctor, Cerebrovascular Disease Center, Gansu Provincial Hospital, No. 204, Donggang West Road, Lanzhou 730000, Gansu Province, China. hyf897@sina.com
Telephone: +86-18893114576
Received: July 30, 2018 Peer-review started: July 30, 2018 First decision: August 31, 2018 Revised: September 20, 2018 Accepted: October 11, 2018 Article in press: October 12, 2018 Published online: November 6, 2018
Abstract
Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition of an unknown etiology and is often associated with immune diseases. However, PG rarely shows visceral involvement, especially in the kidney. A 20-year-old female presented with pedal edema and skin ulceration of both lower limbs. The skin lesion began as an erythematous plaque and then became a blister. She also complained of abdominal distension and a decreasing urine volume. Laboratory data showed high proteinuria, hypoalbuminemia and hyperlipidemia. Her skin and kidney were biopsied. The pathological results indicated PG and immunoglobulin A (IgA) nephropathy. The patient was finally cured with prednisolone in combination with cyclosporine A (CsA).
Core tip: This is the first report of successfully treated pyoderma gangrenosum (PG) occurring concurrently with immunoglobulin A (IgA) nephropathy. Both are immune-mediated disorders and should be paid attention to.
