Lee SW. Liver function improvement after human placental extract injections in patients with chronic liver disease: Thirty case reports. World J Clin Cases 2025; 13(23): 102937 [DOI: 10.12998/wjcc.v13.i23.102937]
Corresponding Author of This Article
Seung-Won Lee, MD, Danaun Medical Clinic, 896 Gwangmyeong-ro, Gwangmyeong-si 14262, Gyeonggi-do, South Korea. gclaennec@gmail.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 16, 2025; 13(23): 102937 Published online Aug 16, 2025. doi: 10.12998/wjcc.v13.i23.102937
Liver function improvement after human placental extract injections in patients with chronic liver disease: Thirty case reports
Seung-Won Lee
Seung-Won Lee, Danaun Medical Clinic, Gwangmyeong-si 14262, Gyeonggi-do, South Korea
Author contributions: Lee SW designed and conducted the study and wrote the manuscript, read and approved the final version of the manuscript to be published.
Informed consent statement: This study was conducted without obtaining individual patient consent as it utilizes post-treatment data. As per institutional and privacy guidelines, we are unable to share any patient-identifiable information. Additionally, as per medical regulations, the first page of the patient records cannot be provided.
Conflict-of-interest statement: The author declares that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Seung-Won Lee, MD, Danaun Medical Clinic, 896 Gwangmyeong-ro, Gwangmyeong-si 14262, Gyeonggi-do, South Korea. gclaennec@gmail.com
Received: November 4, 2024 Revised: March 22, 2025 Accepted: April 27, 2025 Published online: August 16, 2025 Processing time: 214 Days and 3.7 Hours
Abstract
BACKGROUND
This case report describes a protocol developed by Danaun Medical Clinic for the introduction of a pioneering intervention comprising intravenous human placental extract (HPE) therapy to improve the liver function of patients with chronic liver disease (CLD).
CASE SUMMARY
This study involved data from patients whose chief complaint was reduced quality of life attributable to CLD. The new treatment approach resulted in improvements in the liver function and fatty liver of 30 patients with CLD. Improvements were observed using abdominal ultrasonography. Unlike traditional methods, this protocol provided more sustainable and meaningful results. Treatment with 10 mL of HPE administered intravenously once or twice per week significantly improved liver function. The observed improvements in fatty liver and liver function suggest the utility of this approach for the management of patients with CLD.
CONCLUSION
This case series highlights the potential of innovative treatments for patients with CLD that could improve the quality of life of the patients.
Core Tip: In this paper, we describe an innovative treatment method that involved the intravenous administration of 10 mL of human placental extract once or twice a week. This is the first case report on the use of placental extract in patients with chronic liver disease (CLD) through an innovative treatment method. This treatment method can be used to improve liver function in patients with CLD.
