Published online Jan 6, 2023. doi: 10.12998/wjcc.v11.i1.233
Peer-review started: October 24, 2022
First decision: November 11, 2022
Revised: November 24, 2022
Accepted: December 15, 2022
Article in press: December 15, 2022
Published online: January 6, 2023
Bronchiolar adenoma (BA) and ciliated muconodular papillary tumor are rare tumors that have bilayered cell proliferation and continuous expression of p40 and CK5/6 in the basal cell layer. Diagnosis is difficult because of the limited knowledge of these tumors and their morphological similarities to malignant tumors, including invasive mucinous adenocarcinoma, especially based on the histopathology of intraoperative frozen sections. These tumors are now con
A 57-year-old woman presented with a 17.0 mm × 7.0 mm nodule in the lower lobe of the left lung. Hematoxylin-eosin staining and immunohistochemistry of a surgical specimen were performed. The tumor consisted of a BA area and a muc
The present study indicated that BA may be carcinogenic, and suggests that clinicians should be aware of its potential for malignant transformation.
Core Tip: This study adds to the currently limited information regarding the malignant transformation of pulmonary bronchiolar adenomas into mucinous adenocarcinomas. Our results suggest clinicians should have a high index of suspicion when encountering a lesion that appears to be benign.