World J Clin Cases. Nov 16, 2022; 10(32): 11993-11999 Published online Nov 16, 2022. doi: 10.12998/wjcc.v10.i32.11993
Minimal change disease caused by polycythemia vera: A case report
Li Xu, Li-Li Lu, Jian-Dong Gao
Li Xu, Li-Li Lu, Jian-Dong Gao, Department of Nephrology, Shuguang Hospital Affiliated to the Shanghai University of Traditional Chinese Medicine, TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine (20DZ2272200), Shanghai 201203, China
Author contributions: Xu L was responsible for writing the manuscript and data analysis; Lu LL helped with document retrieval; Gao JD was responsible for supervision; all authors agree with the final version of the manuscript.
Supported bythe National Natural Science Foundation of China, No. 81874437 and 81904126; Science and Technology Commission of Shanghai Municipality, No. 20Y21901800.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Jian-Dong Gao, PhD, Professor, Department of Nephrology, Shuguang Hospital Affiliated to the Shanghai University of Traditional Chinese Medicine, TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine (20DZ2272200), No. 528 Road ZhangHeng, Shanghai 201203, China. jiandong.gao@shutcm.edu.cn
Received: August 24, 2022 Peer-review started: August 24, 2022 First decision: September 23, 2022 Revised: September 27, 2022 Accepted: October 19, 2022 Article in press: October 19, 2022 Published online: November 16, 2022 Processing time: 75 Days and 18.4 Hours
Abstract
BACKGROUND
Polycythemia vera (PV), often attributed to the JAK2 V617F mutation, is characterized by enhanced red blood cell counts in the peripheral blood. PV-associated renal disease is clinically rare; to date, there have been reports of other chronic kidney diseases related to PV, but no reports on PV-associated minimal change disease.
CASE SUMMARY
A 37-year-old man presented with proteinuria and high red blood cell count on January 4, 2021. The patient underwent bone marrow and renal biopsies, then was subsequently diagnosed with PV and minimal change in disease. Hydroxyurea was administered and proteinuria remission was achieved. The patient’s last visit was on April 14, 2022.
CONCLUSION
We inferred that there may be a causal relationship between PV and minimal change disease.
Core Tip: Polycythemia vera (PV) is a myeloproliferative neoplasm that can influence the immune system and affect organs such as the kidneys. This is the first report of PV-associated minimal change disease. In our case, hydroxyurea administration was effective and proteinuria remission was achieved. Therefore, we infer there may be a causal relationship between PV and minimal change disease.
