Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 21, 2022; 10(3): 1016-1023
Published online Jan 21, 2022. doi: 10.12998/wjcc.v10.i3.1016
Pulmonary amyloidosis and multiple myeloma mimicking lymphoma in a patient with Sjogren’s syndrome: A case report
Joa Kim, Yun Sung Kim, Hee Jeong Lee, Sang Gon Park
Joa Kim, Yun Sung Kim, Department of Internal Medicine, Rheumatology, Chosun University Hospital, Gwangju 501-717, South Korea
Hee Jeong Lee, Department of Internal Medicine, Chosun University Hospital, Gwangju 501-717, South Korea
Sang Gon Park, Department of Internal Medicine, Hemato-Oncology, Chosun University Hospital, Gwangju 501-717, South Korea
Author contributions: Kim J, Kim YS, Park SG and Lee HJ contributed to the conception, writing and final proofing of this work.
Supported by a Research Fund from Chosun University Hospital, 2018.
Informed consent statement: The study participant was provided with an informed written consent prior to study enrollment.
Conflict-of-interest statement: No conflict-of-interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016) statement, and the manuscript was prepared and revised according to the CARE Checklist (2016) statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hee Jeong Lee, MD, PhD, Doctor, Department of Internal Medicine, Chosun University Hospital, Pilmun-daero, Gwangju 501-717, South Korea. hjangel21c@hanmail.net
Received: June 2, 2021
Peer-review started: June 2, 2021
First decision: June 25, 2021
Revised: July 5, 2021
Accepted: December 22, 2021
Article in press: December 22, 2021
Published online: January 21, 2022
Abstract
BACKGROUND

Sjogren’s syndrome (SS), which affect salivary gland function, is an autoimmune disease. SS may involve extraglandular organs. Approximately 10 to 20 percent of SS patients have clinically significant lung disease, but presentation of pulmonary amylodosis is extremly rare. The incidence of benign monoclonal gammopathy in SS patients is high, but multiple myeloma is rare. No case involving the simultaneous occurrence of two rare diseases, pulmonary amyloidosis and multiple myeloma, in the same patient with SS has been reported so far.

CASE SUMMARY

A 41-year-old male patient was referred to our hematology department due to incidentally detected gastric plasmacytoma. He had been diagnosed with SS four years earlier. Multiple miliary nodules, ground glass opacity in both lung fields, and enlargement of both inguinal lymph nodes was observed on chest and abdomen computer tomography. Based on the pathological findings of lung and lymph node biopsied specimens, the patient was diagnosed with pulmonary amyloidosis and multiple myeloma. Pulmonary amyloidosis and multiple myeloma associated with SS has rarely been reported.

CONCLUSION

This is an extremely rare case of simultaneous pulmonary amyloidosis and multiple myeloma in the same patient with SS.

Keywords: Case report, Sjogren’s syndrome, Amyloidosis, Multiple myeloma, Plasmacytoma

Core Tip: Sjogren’s syndrome (SS) is known for its involvement in exocrine glands, and may also involve extraglandular organs. Interstitial lung disease is the most common pulmonary abnormality in primary SS, but pulmonary amyloidosis is rare. In addition, the incidence of benign monoclonal gammopathy in SS patients is relatively high, but multiple myeloma is very rare. Herein, we report the extremely rare case of simultaneous pulmonary amyloidosis and multiple myeloma in the same patient with SS.