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Gencer A, Ozcibik G, Karakas FG, Sarbay I, Batur S, Borekci S, Turna A. Two smoking-related lesions in the same pulmonary lobe of squamous cell carcinoma and pulmonary Langerhans cell histiocytosis: A case report . World J Clin Cases 2022; 10(19): 6722-6727 [PMID: 35979280 DOI: 10.12998/wjcc.v10.i19.6722]
Aysegul Gencer, Fatma Gulsum Karakas, Sermin Borekci, Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty Campus, Istanbul 34098, Turkey
Gizem Ozcibik, Ismail Sarbay, Akif Turna, Department of Thoracic Surgery, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul 34098, Turkey
Sebnem Batur, Department of Pathology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul 34098, Turkey
Author contributions: Gencer A and Karakas FG collected the patient data and performed his follow-up; Ozcibik G, Sarbay I and Turna A performed the operation; Batur S performed immunohistochemical analyses; Gencer A, Borekci S and Turna A wrote the paper; all authors have read and approved the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Aysegul Gencer, MD, Academic Research, Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty Campus, Kocamustafapasa Street, No. 53, Cerrahpasa 34098 Fatih, Istanbul 34098, Turkey. aysegulbozkurtgencer@gmail.com
Received: February 28, 2022 Peer-review started: February 28, 2022 First decision: April 8, 2022 Revised: April 14, 2022 Accepted: April 24, 2022 Article in press: April 24, 2022 Published online: July 6, 2022 Processing time: 115 Days and 13.1 Hours
Abstract
BACKGROUND
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare cystic lung disease usually affecting young adults. It is predicted that PLCH is a lung tumor precursor associated with dysfunction of the myeloid dendritic cells in the lung.
CASE SUMMARY
A 70-year-old male patient presented with chronic cough and sputum. He had symptoms for 5 years and described shortness of breath on exertion for the previous 3 years. He had a 60 packs/year smoking history. Computerized tomography of the thorax revealed an 11-mm nodule in the right lung lower lobe superior segment and a 7-mm nodule in the right lung lower lobe poster basal segment. Those two nodules were resected by means of right thoracoscopic surgery. Pathological evaluation revealed a squamous cell carcinoma and PLCH.
CONCLUSION
Coexistent squamous cell carcinoma and PLCH suggest possible association between PLCH and lung cancer.
Core Tip: The BRAF mutation is associated with a number of tumors, it is thought that Pulmonary Langerhans cell histiocytosis (PLCH) may be a precursor of malignancy. In this case, the diagnosis of PLCH concurrently with the diagnosis of lung squamous cell carcinoma and the detection of BRAF mutation supported this hypothesis.
