Published online Jul 6, 2022. doi: 10.12998/wjcc.v10.i19.6722
Peer-review started: February 28, 2022
First decision: April 8, 2022
Revised: April 14, 2022
Accepted: April 24, 2022
Article in press: April 24, 2022
Published online: July 6, 2022
Pulmonary Langerhans cell histiocytosis (PLCH) is a rare cystic lung disease usually affecting young adults. It is predicted that PLCH is a lung tumor precursor associated with dysfunction of the myeloid dendritic cells in the lung.
A 70-year-old male patient presented with chronic cough and sputum. He had symptoms for 5 years and described shortness of breath on exertion for the previous 3 years. He had a 60 packs/year smoking history. Computerized tomography of the thorax revealed an 11-mm nodule in the right lung lower lobe superior segment and a 7-mm nodule in the right lung lower lobe poster basal segment. Those two nodules were resected by means of right thoracoscopic surgery. Pathological evaluation revealed a squamous cell carcinoma and PLCH.
Coexistent squamous cell carcinoma and PLCH suggest possible association between PLCH and lung cancer.
Core Tip: The BRAF mutation is associated with a number of tumors, it is thought that Pulmonary Langerhans cell histiocytosis (PLCH) may be a precursor of malignancy. In this case, the diagnosis of PLCH concurrently with the diagnosis of lung squamous cell carcinoma and the detection of BRAF mutation supported this hypothesis.