Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2022; 10(17): 5869-5876
Published online Jun 16, 2022. doi: 10.12998/wjcc.v10.i17.5869
Lung adenocarcinoma metastasis to paranasal sinus: A case report
Wen-Jing Li, Hai-Xiang Xue, Jian-Qiang You, Chang-Jiang Chao
Wen-Jing Li, Hai-Xiang Xue, Jian-Qiang You, Chang-Jiang Chao, Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu Province, China
Author contributions: Li WJ contributed to formal analysis, methodology, data processing, resources, investigation, writing-original draft, writing-review and editing; Xue HX contributed to investigation, methodology, validation; You JQ contributed to methodology, validation; Chao CJ contributed to methodology, supervision, writing-review and editing.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Chang-Jiang Chao, Doctor, Professor, Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, Changzhou 213000, Jiangsu Province, China.
Received: December 26, 2021
Peer-review started: December 26, 2021
First decision: January 25, 2022
Revised: February 6, 2022
Accepted: April 4, 2022
Article in press: April 4, 2022
Published online: June 16, 2022

Lung cancer is often metastasized to the brain, liver, kidneys, bone, bone marrow, and adrenal glands; however, metastasis of primary lung cancer to the paranasal sinuses is extremely rare.


In this paper, we present a case of metastatic tumors of the sinus secondary to lung adenocarcinoma. The patient was a 46-year-old woman who underwent surgical removal of lung carcinoma. Four months after the surgical removal of the lung tumor, the patient presented with epistaxis, and on investigation, the diagnosis was confirmed to be nasal sinus tumors due to metastasis of lung adenocarcinoma.


Thorough investigation of patients with epistaxis and a history of lung cancer is necessary to diagnose metastatic sinus tumors. We reviewed relevant literature and found that there are no characteristic clinical or radiologic features for metastatic sinus tumors; however, the diagnosis can be confirmed by histopathological examination of biopsied tumor sample.

Keywords: Lung adenocarcinoma, Paranasal sinus, Metastasis, Case report

Core Tip: Lung adenocarcinoma metastasis restricted to the paranasal sinus is a rare phenomenon. In this report, we present a rare case of metastatic tumors of the sinus secondary to lung adenocarcinoma. After lung cancer surgery, the patient had no postoperative complications and was completely asymptomatic at the second-year postoperative follow-up. We reviewed relevant literature in order to identify the characteristic features observed in cases of sinus metastasis of lung adenocarcinoma.