Flap failure prediction in microvascular tissue reconstruction using machine learning algorithms

Abstract

BACKGROUND

Microvascular tissue reconstruction is a well-established, commonly used technique for a wide variety of the tissue defects. However, flap failure is associated with an additional hospital stay, medical cost burden, and mental stress. Therefore, understanding of the risk factors associated with this event is of utmost importance.

AIM

To develop machine learning-based predictive models for flap failure to identify the potential factors and screen out high-risk patients.

METHODS

Using the data set of 946 consecutive patients, who underwent microvascular tissue reconstruction of free flap reconstruction for head and neck, breast, back, and extremity, we established three machine learning models including random forest classifier, support vector machine, and gradient boosting. Model performances were evaluated by the indicators such as area under the curve of receiver operating characteristic curve, accuracy, precision, recall, and F1 score. A multivariable regression analysis was performed for the most critical variables in the random forest model.

RESULTS

Post-surgery, the flap failure event occurred in 34 patients (3.6%). The machine learning models based on various preoperative and intraoperative variables were successfully developed. Among them, the random forest classifier reached the best performance in receiver operating characteristic curve, with an area under the curve score of 0.770 in the test set. The top 10 variables in the random forest were age, body mass index, ischemia time, smoking, diabetes, experience, prior chemotherapy, hypertension, insulin, and obesity. Interestingly, only age, body mass index, and ischemic time were statistically associated with the outcomes.

CONCLUSION

Machine learning-based algorithms, especially the random forest classifier, were very important in categorizing patients at high risk of flap failure. The occurrence of flap failure was a multifactor-driven event and was identified with numerous factors that warrant further investigation. Importantly, the successful application of machine learning models may help the clinician in decision-making, understanding the underlying pathologic mechanisms of the disease, and improving the long-term outcome of patients.

Keywords: Machine learning, Flap failure, Microvascular procedure, Random forest, Risk factors

Core Tip: Flap failure is a rare but severe event in microvascular tissue reconstruction. It is generally associated with the additional economic burden and mental stress to the patients. Therefore, identifying the risk factors and screening high-risk patients carries a significant value in the clinical practice. Machine learning is an artificial intelligence based on the computer learning to learn from data and thus automatically make decisions. This retrospective study applied machine learning for the risk factor analysis of flap failure during microvascular tissue reconstruction.